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Protein Overview: SPN1

General Information:
Name(s) found: SPN1 / YPR133C [SGD]
Description(s) found:
Found 28 descriptions.
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  • Protein that interacts with Spt6p and copurifies with Spt5p and RNA polymerase II, probable transcriptional elongation factor; metazoan homologs contain an acidic N terminus; mutations in the gene confer an Spt- phenotype [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 410 amino acids

    Gene Ontology:
    Cellular Component: transcription elongation factor complex [IPILink to PubMed article]
    Biological Process: RNA elongation from RNA polymerase II promoter [IPILink to PubMed article]
    Molecular Function: RNA polymerase II transcription elongation factor activity [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTADQEQPK VVEATPEDGT ASSQKSTINA ENENTKQNQS MEPQETSKGT SNDTKDPDNG  60
   61 EKNEEAAIDE NSNVEAAERK RKHISTDFSD DDLEKEEHND QSLQPTVENR ASKDRDSSAT 120
  121 PSSRQELEEK LDRILKKPKV RRTRRDEDDL EQYLDEKILR LKDEMNIAAQ LDIDTLNKRI 180
  181 ETGDTSLIAM QKVKLLPKVV SVLSKANLAD TILDNNLLQS VRIWLEPLPD GSLPSFEIQK 240
  241 SLFAALNDLP VKTEHLKESG LGRVVIFYTK SKRVEAQLAR LAEKLIAEWT RPIIGASDNY 300
  301 RDKRIMQLEF DSEKLRKKSV MDSAKNRKKK SKSGEDPTSR GSSVQTLYEQ AAARRNRAAA 360
  361 PAQTTTDYKY APVSNLSAVP TNARAVGVGS TLNNSEMYKR LTSRLNKKHK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) SPN1 SPT6
    View Details Gavin AC, et al. (2002) CKA1 CKA2 CKB1 SPN1 SPT6
    View Details Qiu et al. (2008) CDC73 CHD1 CTR9 ELC1 ELP3 ELP6 IKI1 IKI3 PAF1 RTF1 SPN1 SPT16 SPT4 SPT5

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #33 Asynchronous SPB prep Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data SPN1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..227] MSA 86.132997 View MSA. No confident structure predictions are available.
    2 View Details [228..280] deduced N/A No confident structure predictions are available.
    3 View Details [281..410] MSA 1.018969 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle