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Protein Overview: ELP3

General Information:
Name(s) found: ELP3 / YPL086C [SGD]
Description(s) found:
Found 29 descriptions.
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  • Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; exhibits histone acetyltransferase activity that is directed to histones H3 and H4; disruption confers resistance to K. lactis zymotoxin [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 557 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    transcription elongation factor complex [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: tRNA modification [IMPLink to PubMed article]
    regulation of transcription from RNA polymerase II promoter [IMPLink to PubMed article]
    Molecular Function: histone acetyltransferase activity [IDALink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MARHGKGPKT NKKKLAPEKE RFIQCCADIT LELTDSLTSG TTREINLNGL ITKYSKKYKL  60
   61 KQQPRLTDII NSIPDQYKKY LLPKLKAKPV RTASGIAVVA VMCKPHRCPH IAYTGNICVY 120
  121 CPGGPDSDFE YSTQSYTGYE PTSMRAIRAR YDPYEQARGR VEQLKQLGHS IDKVEYVLMG 180
  181 GTFMSLPKEY REDFIVKLHN ALSGFNGNDI DEAILYSQQS LTKCVGITIE TRPDYCTQTH 240
  241 LDDMLKYGCT RLEIGVQSLY EDVARDTNRG HTVRSVCETF AVSKDAGYKV VSHMMPDLPN 300
  301 VGMERDIEQF KEYFENPDFR TDGLKIYPTL VIRGTGLYEL WKTGRYKSYS ANALVDLVAR 360
  361 ILALVPPWTR IYRVQRDIPM PLVTSGVDNG NLRELALARM KDLGTTCRDV RTREVGIQEV 420
  421 HHKVQPDQVE LIRRDYYANG GWETFLSYED PKKDILIGLL RLRKASKKYT YRKEFTSQRT 480
  481 SIVRELHVYG SVVPLHSRDP RKFQHQGFGT LLMEEAERIA KEEHGSEKIS VISGVGVRNY 540
  541 YGKLGYELDG PYMSKRI

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ELP2 ELP3 ELP4 ELP6 IKI1 IKI3 YIL096C
    View Details Krogan NJ, et al. (2006) ELP2 ELP3 ELP4 IKI1 IKI3 KTI12 YIL096C
    View Details Gavin AC, et al. (2006) ELP2 ELP3 ELP4 IKI1 IKI3
    View Details Gavin AC, et al. (2002) ELP2 ELP3 ELP4 IKI1 IKI3
    View Details Ho Y, et al. (2002) ELP2 ELP3 IKI3 NIS1 RSF2
    View Details Qiu et al. (2008) ELC1 ELP2 ELP3 ELP4 ELP6 IKI1 IKI3 SPN1 SPT4

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data ELP3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..423] MSA 126.850997 View MSA. No confident structure predictions are available.
    2 View Details [424..557] Pfam 6.508638 Acetyltransferase (GNAT) family No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  1.62614606868017 bayes_pls_golite062009
  • catalytic activity
    		•  1.48331922124015 bayes_pls_golite062009
  • transferase activity
    		•  1.38870107531698 bayes_pls_golite062009
  • protein binding
    		•  0.374124957429525 bayes_pls_golite062009
    2
    Term Confidence Notes
  • transferase activity
    		•  3.26226130947208 bayes_pls_golite062009
  • N-acyltransferase activity
    		•  3.22332766762816 bayes_pls_golite062009
  • N-acetyltransferase activity
    		•  3.16285222477063 bayes_pls_golite062009
  • histone acetyltransferase activity
    		•  3.09883679214009 bayes_pls_golite062009
  • lysine N-acetyltransferase activity
    		•  3.09883679214009 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  3.06288276492113 bayes_pls_golite062009
  • acetyltransferase activity
    		•  2.29329191833529 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.26346740872821 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.14720849412601 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  2.05664878927078 bayes_pls_golite062009
  • catalytic activity
    		•  1.823104805379 bayes_pls_golite062009
  • binding
    		•  1.30356860355657 bayes_pls_golite062009
  • transcription coactivator activity
    		•  1.05620338082006 bayes_pls_golite062009
  • transcription factor binding
    		•  0.999468823887739 bayes_pls_golite062009
  • transferase activity, transferring acyl groups other than amino-acyl groups
    		•  0.934738369878547 bayes_pls_golite062009
  • acyltransferase activity
    		•  0.930618573930377 bayes_pls_golite062009
  • transcription activator activity
    		•  0.800725992277502 bayes_pls_golite062009
    		• 0.720242802910078 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.60912193595326 bayes_pls_golite062009
  • RNA binding
    		•  0.314555310175452 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.207688916644661 bayes_pls_golite062009
  • protein binding
    		•  0.116359302536336 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle