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Protein Overview: IKI3

General Information:
Name(s) found: IKI3 / YLR384C [SGD]
Description(s) found:
Found 26 descriptions.
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  • Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD) [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1349 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    transcription elongation factor complex [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: tRNA modification [IMPLink to PubMed article]
    regulation of transcription from RNA polymerase II promoter [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVEHDKSGSK RQELRSNMRN LITLNKGKFK PTASTAEGDE DDLSFTLLDS VFDTLSDSIT  60
   61 CVLGSTDIGA IEVQQFMKDG SRNVLASFNI QTFDDKLLSF VHFADINQLV FVFEQGDIIT 120
  121 ATYDPVSLDP AETLIEIMGT IDNGIAAAQW SYDEETLAMV TKDRNVVVLS KLFEPISEYH 180
  181 LEVDDLKISK HVTVGWGKKE TQFRGKGARA MEREALASLK ASGLVGNQLR DPTMPYMVDT 240
  241 GDVTALDSHE ITISWRGDCD YFAVSSVEEV PDEDDETKSI KRRAFRVFSR EGQLDSASEP 300
  301 VTGMEHQLSW KPQGSLIASI QRKTDLGEED SVDVIFFERN GLRHGEFDTR LPLDEKVESV 360
  361 CWNSNSEALA VVLANRIQLW TSKNYHWYLK QELYASDISY VKWHPEKDFT LMFSDAGFIN 420
  421 IVDFAYKMAQ GPTLEPFDNG TSLVVDGRTV NITPLALANV PPPMYYRDFE TPGNVLDVAC 480
  481 SFSNEIYAAI NKDVLIFAAV PSIEEMKKGK HPSIVCEFPK SEFTSEVDSL RQVAFINDSI 540
  541 VGVLLDTDNL SRIALLDIQD ITQPTLITIV EVYDKIVLLR SDFDYNHLVY ETRDGTVCQL 600
  601 DAEGQLMEIT KFPQLVRDFR VKRVHNTSAE DDDNWSAESS ELVAFGITNN GKLFANQVLL 660
  661 ASAVTSLEIT DSFLLFTTAQ HNLQFVHLNS TDFKPLPLVE EGVEDERVRA IERGSILVSV 720
  721 IPSKSSVVLQ ATRGNLETIY PRIMVLAEVR KNIMAKRYKE AFIVCRTHRI NLDILHDYAP 780
  781 ELFIENLEVF INQIGRVDYL NLFISCLSED DVTKTKYKET LYSGISKSFG MEPAPLTEMQ 840
  841 IYMKKKMFDP KTSKVNKICD AVLNVLLSNP EYKKKYLQTI ITAYASQNPQ NLSAALKLIS 900
  901 ELENSEEKDS CVTYLCFLQD VNVVYKSALS LYDVSLALLV AQKSQMDPRE YLPFLQELQD 960
  961 NEPLRRKFLI DDYLGNYEKA LEHLSEIDKD GNVSEEVIDY VESHDLYKHG LALYRYDSEK1020
 1021 QNVIYNIYAK HLSSNQMYTD AAVAYEMLGK LKEAMGAYQS AKRWREAMSI AVQKFPEEVE1080
 1081 SVAEELISSL TFEHRYVDAA DIQLEYLDNV KEAVALYCKA YRYDIASLVA IKAKKDELLE1140
 1141 EVVDPGLGEG FGIIAELLAD CKGQINSQLR RLRELRAKKE ENPYAFYGQE TEQADDVSVA1200
 1201 PSETSTQESF FTRYTGKTGG TAKTGASRRT AKNKRREERK RARGKKGTIY EEEYLVQSVG1260
 1261 RLIERLNQTK PDAVRVVEGL CRRNMREQAH QIQKNFVEVL DLLKANVKEI YSISEKDRER1320
 1321 VNENGEVYYI PEIPVPEIHD FPKSHIVDF

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ELP2 ELP3 ELP4 ELP6 IKI1 IKI3
    View Details Krogan NJ, et al. (2006) ELP2 ELP3 ELP4 IKI1 IKI3 KTI12 YIL096C
    View Details Gavin AC, et al. (2006) ELP2 ELP3 ELP4 IKI1 IKI3
    View Details Gavin AC, et al. (2002) ELP2 ELP3 ELP4 IKI1 IKI3
    View Details Ho Y, et al. (2002) ELP2 ELP3 IKI3 NIS1 RSF2
    View Details Qiu et al. (2008) CHD1 ELC1 ELP2 ELP3 ELP4 ELP6 IKI1 IKI3 RTF1 SPN1 SPT4 SPT6

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run PAN1 No Comments Toshima J, et al (2006)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi1 with gst from october 2005 McCusker D, et al (2007)
    View Run BOI1 Sample bob1 (2nd set) from october 2005 McCusker D, et al (2007)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen CPD1 IKI3 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data IKI3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..548] PSI-BLAST 67.69897 Actin interacting protein 1
    2 View Details [549..629] deduced N/A No confident structure predictions are available.
    3 View Details [630..1188] FFAS03 2.25 No description for 2gw1A was found.
    4 View Details [1189..1349] MSA 1.045961 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle