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Protein Overview: ELP4

General Information:
Name(s) found: ELP4 / YPL101W [SGD]
Description(s) found:
Found 24 descriptions.
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  • Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 456 amino acids

    Gene Ontology:
    Cellular Component: transcription elongation factor complex [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: tRNA modification [IMPLink to PubMed article]
    regulation of transcription from RNA polymerase II promoter [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFRKRGEIL NDRGSGLRGP LLRGPPRTSS TPLRTGNRRA PGNVPLSDTT ARLKKLNIAD  60
   61 ESKTKMGLDS SHVGVRPSPA TSQPTTSTGS ADLDSILGHM GLPLGNSVLV EEQSTTEFHS 120
  121 ILGKLFAAQG IVHNRISDSS ADKTRNGDTH VIVLSLNQMF AKELPGIYKG SRKQMKKNLI 180
  181 SEEESKVTVQ NLNETQRSTP SRYKDLKIAW KYKLADEKRL GSPDRDDIQQ NSEYKDYNHQ 240
  241 FDITTRLMPA PIASELTFIA PTQPVSTILS QIEQTIKRND KKLIRIVIPS LLHPAMYPPK 300
  301 MFESSEIIGL MHGVRSLVKK YYERVVLFAS ISIDIITPPL LVLLRNMFDS VINLEPFNQE 360
  361 MTEFLERVYK SQPGKIQHGL VHILKLPVFT DRGEMRVLKS EWAFKNGRKK FEIEQWGIPV 420
  421 DDAEGSAASE QSHSHSHSDE ISHNIPAKKT KISLDY

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ELP2 ELP3 ELP4 ELP6 IKI1 IKI3
    View Details Krogan NJ, et al. (2006) ELP2 ELP3 ELP4 IKI1 IKI3 KTI12 YIL096C
    View Details Gavin AC, et al. (2006) ELP2 ELP3 ELP4 IKI1 IKI3
    View Details Gavin AC, et al. (2002) ELP2 ELP3 ELP4 IKI1 IKI3
    View Details Qiu et al. (2008) ELP2 ELP3 ELP4 ELP6 IKI1 IKI3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..302] MSA 2.013961 View MSA. No confident structure predictions are available.
    2 View Details [303..456] MSA 1.013976 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.91

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle