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Protein Overview: NOP12

General Information:
Name(s) found: NOP12 / YOL041C [SGD]
Description(s) found:
Found 33 descriptions.
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  • Nucleolar protein involved in pre-25S rRNA processing and biogenesis of large 60S ribosomal subunit; contains an RNA recognition motif (RRM); binds to Ebp2; similar to Nop13p and Nsr1p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 459 amino acids

    Gene Ontology:
    Cellular Component: nucleolus [IDALink to PubMed article]
    Biological Process: rRNA metabolic process [IMPLink to PubMed article]
    Molecular Function: RNA binding [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSAIDNLFG NIDEKKIESS VDKLFSSSCG PINKLEVKSK TRTVLPDSKK RERAAEADQE  60
   61 EKEASKPDVS DEQTEEVALP KVKKAKKSKR NDEDEDLEAR YYAKLLNEEA EAEDDKPTVT 120
  121 KTDETSVPLT SAAKKVDFKE DELEKAERTV FIGNILSTVI TSKKVYKEFK KLFGTNPIAE 180
  181 TEESGNEKEE ESSKKSDNNE FAIESIRFRS ISFDEALPRK VAFVQQKFHK SRDTINAYIV 240
  241 YKNKSAVRKI CSNLNAVVFQ DHHLRVDSVA HPAPHDKKRS IFVGNLDFEE IEESLWKHFE 300
  301 PCGDIEYVRI IRDSKTNMGK GFAYVQFKDL QSVNKALLLN EKPMKSQKQE DENTKKPTKK 360
  361 ARKLRVSRCK NMKKGTTIGT GLDRNGLTDS QRTRAGRAKK ILGKADRATL GQEITIEGLR 420
  421 AKKGEGSTHL KKKKQRSATG RVTKRSIAFK KAQAEKSKK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) BRX1 CIC1 EBP2 ERB1 HAS1 HCA4 IMD3 KRE33 KRI1 MAK21 MAK5 NOC2 NOC3 NOG1 NOP1 NOP12 NOP2 NOP4 NOP56 NOP7 NUG1 PUF6 PWP1 RLP7 RPF2 RPL15A RPL5 RPL6A RRP12 RRP5 UTP10 UTP22 YTM1
    View Details Krogan NJ, et al. (2006) GDT1 MRD1 NOP12 RRP17
    View Details Gavin AC, et al. (2002) AAR2 ADE4 ARX1 BEM2 BFR2 BMS1 BRX1 BUD20 BUD21 CBF5 CCT8 CFT2 CIC1 CLU1 CYR1 CYS4 DBP10 DBP8 DBP9 DCP2 DIP2 DRS1 EBP2 ECM16 ECM29 EMG1 ENP1 ENP2 ERB1 ERO1 ESF1 ESF2 FIP1 FPR4 FUN12 GAR1 GCN1 GLC7 HAS1 HCA4 HDA1 HER1 HHF1, HHF2 HIS3 HSL1 HTA2 IMP3 IMP4 INP2 IPI1 IPI3 IRR1 KAP123 KRE33 KRR1 LHP1 LOC1 LSG1 MAK21 MAK5 MCD1 MDN1 MIS1 MPP10 MRP7 MRT4 MVD1 NAN1 NAP1 NHP2 NIP1 NIP7 NMD3 NOC2 NOC3 NOC4 NOG1 NOG2 NOP1 NOP12 NOP14 NOP15 NOP16 NOP2 NOP4 NOP56 NOP58 NOP6 NOP7 NSA1 NSA2 NUG1 PAP1 PFS2 POL2 PRE6 PRE9 PRP4 PRP43 PRT1 PTA1 PTI1 PUF6 PWP2 REF2 REI1 RIX1 RIX7 RLP24 RLP7 RML2 RNA14 ROK1 RPA135 RPA190 RPF1 RPF2 RPG1 RPP2B RPT6 RRP1 RRP12 RRP9 RSA3 RSA4 RTG2 RTR1 RVB2 SCC4 SCL1 SDA1 SEC21 SEC7 SKI2 SMB1 SMC1 SMC3 SNU114 SNU13 SNU66 SOF1 SPB1 SPB4 SRO9 SSF1 TIF1, TIF2 TIF4631 TIF4632 TIF6 TUB3 URB1 UTP10 UTP11 UTP13 UTP15 UTP18 UTP20 UTP21 UTP22 UTP30 UTP4 UTP6 UTP7 UTP8 UTP9 YGL036W YHB1 YMR310C YSH1 YTM1
    View Details Ho Y, et al. (2002) AAC3 ADH2 AFG2 AI1 AIM46 ALB1 ARE1 ARX1 BMS1 BUD20 CBF5 CBP2 CCM1 CDC16 CDC33 CDC5 CDC53 CIC1 CKA1 CKA2 CKB1 CKB2 COF1 CTF4 CYS4 DBP10 DBP2 DBP7 DED81 DIA2 EBP2 EGD1 EHD3 ELA1 ENP1 ENP2 ERB1 ESF1 ESF2 FET4 FPR3 FUN12 FYV4 GBP2 GDE1 GND1 GRS1 GSP1 HAS1 HHF1, HHF2 HHO1 HHT1, HHT2 HMO1 HOT1 HTA1 HTB1 HTB2 ICP55 ILS1 IMD1 IMD2 IMD3 IMD4 ISA1 KRE33 KRI1 LAA1 LHP1 LOC1 LST4 MAG1 MAG2 MAM33 MCM2 MCM3 MCM5 MES1 MGM101 MIG1 MKT1 MMS4 MNP1 MPH1 MRPL1 MRPS16 MSC3 MSH2 MSS116 MUS81 NHP2 NIP7 NMD3 NOB1 NOC2 NOC3 NOG1 NOP1 NOP12 NOP13 NOP2 NOP4 NOP56 NOP6 NOP7 NPL3 NSA2 NUG1 OYE2 PDC6 PDI1 PET127 PMA1 POB3 POL2 POL5 PRP43 PUF6 PWP1 RAD53 RET1 RIX1 RLI1 RPC10 RPC82 RPF2 RRP12 RRP14 RRP5 RSM24 RSM25 SEC23 SEH1 SFP1 SKP1 SLT2 SPB1 SPT16 SPT2 SRP1 SSF1 SSF2 SSZ1 STE23 SUP45 TAF14 TIF4631 TIF4632 TIF6 TIS11 TMA29 TRA1 TRL1 TSR1 UBI4 URB1 URB2 UTP10 UTP20 UTP22 UTP7 VMR1 VPS73 WTM2 YAK1 YBL044W YBL104C YCR087W YDR102C YER077C YER084W YHB1 YPP1 YRA1 YTM1
    View Details Qiu et al. (2008) BRX1 DBP3 DBP6 DBP7 DRS1 GAR1 HCA4 KRR1 MRT4 NAN1 NOP12 NOP13 NOP15 NOP7 NSR1 NUG1 PWP2 PXR1 RPL27A SOF1 SPB4 TIF6 UTP13 UTP15 UTP4 UTP5 UTP6 UTP9

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run PAN1 No Comments Toshima J, et al (2006)
    View Run MLP2 #35 Asynchronous SPB prep Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #10 Mitotic Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen PRP42 NOP12 1 Unpublished Fields Lab Data
    View Screen TEM1 NOP12 1 Unpublished Fields Lab Data
    View Screen PFS2 NOP12 1 Unpublished Fields Lab Data
    View Screen IQG1 NOP12 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data NOP12 Huh WK, et al. (2003)
    View Data NOP12 and NOP56 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..90] PSI-BLAST 7.69897 Nucleolin
    2 View Details [91..148] deduced N/A No confident structure predictions are available.
    3 View Details [149..270] PSI-BLAST 109.519517 Nuclear ribonucleoprotein A1 (RNP A1, UP1)
    4 View Details [271..372] PSI-BLAST 109.519517 Nuclear ribonucleoprotein A1 (RNP A1, UP1)
    5 View Details [373..459] MSA 1.362997 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • RNA binding
    		•  6.04120049976231 bayes_pls_golite062009
  • mRNA binding
    		•  4.29904003387927 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.81920018903278 bayes_pls_golite062009
    		• 3.36965439092178 bayes_pls_golite062009
  • binding
    		•  3.05116833253954 bayes_pls_golite062009
  • single-stranded RNA binding
    		•  2.32565125258004 bayes_pls_golite062009
  • poly-pyrimidine tract binding
    		•  1.99190411806363 bayes_pls_golite062009
  • structural molecule activity
    		•  1.29928829870122 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.07788694919471 bayes_pls_golite062009
  • DNA binding
    		•  0.978604858165557 bayes_pls_golite062009
  • protein binding
    		•  0.89093640300829 bayes_pls_golite062009
  • snoRNA binding
    		•  0.87536768969411 bayes_pls_golite062009
  • snRNA binding
    		•  0.45487108214667 bayes_pls_golite062009
  • transcription factor activity
    		•  0.234742017105535 bayes_pls_golite062009
    2 No functions predicted.
    3
    Term Confidence Notes
  • RNA binding
    		•  6.04120049976231 bayes_pls_golite062009
  • mRNA binding
    		•  4.29904003387927 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.81920018903278 bayes_pls_golite062009
    		• 3.36965439092178 bayes_pls_golite062009
  • binding
    		•  3.05116833253954 bayes_pls_golite062009
  • single-stranded RNA binding
    		•  2.32565125258004 bayes_pls_golite062009
  • poly-pyrimidine tract binding
    		•  1.99190411806363 bayes_pls_golite062009
  • structural molecule activity
    		•  1.29928829870122 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.07788694919471 bayes_pls_golite062009
  • DNA binding
    		•  0.978604858165557 bayes_pls_golite062009
  • protein binding
    		•  0.89093640300829 bayes_pls_golite062009
  • snoRNA binding
    		•  0.87536768969411 bayes_pls_golite062009
  • snRNA binding
    		•  0.45487108214667 bayes_pls_golite062009
  • transcription factor activity
    		•  0.234742017105535 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle