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Protein Overview: CYS4

General Information:
Name(s) found: CYS4 / YGR155W [SGD]
Description(s) found:
Found 34 descriptions.
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  • Cystathionine beta-synthase, catalyzes synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis; responsible for hydrogen sulfide generation; mutations in human ortholog cause homocystinuria [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 507 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed articleLink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    Biological Process: response to drug [IMPLink to PubMed article]
    cysteine biosynthetic process [IMPLink to PubMed article]
    Molecular Function: cystathionine beta-synthase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTKSEQQADS RHNVIDLVGN TPLIALKKLP KALGIKPQIY AKLELYNPGG SIKDRIAKSM  60
   61 VEEAEASGRI HPSRSTLIEP TSGNTGIGLA LIGAIKGYRT IITLPEKMSN EKVSVLKALG 120
  121 AEIIRTPTAA AWDSPESHIG VAKKLEKEIP GAVILDQYNN MMNPEAHYFG TGREIQRQLE 180
  181 DLNLFDNLRA VVAGAGTGGT ISGISKYLKE QNDKIQIVGA DPFGSILAQP ENLNKTDITD 240
  241 YKVEGIGYDF VPQVLDRKLI DVWYKTDDKP SFKYARQLIS NEGVLVGGSS GSAFTAVVKY 300
  301 CEDHPELTED DVIVAIFPDS IRSYLTKFVD DEWLKKNNLW DDDVLARFDS SKLEASTTKY 360
  361 ADVFGNATVK DLHLKPVVSV KETAKVTDVI KILKDNGFDQ LPVLTEDGKL SGLVTLSELL 420
  421 RKLSINNSNN DNTIKGKYLD FKKLNNFNDV SSYNENKSGK KKFIKFDENS KLSDLNRFFE 480
  481 KNSSAVITDG LKPIHIVTKM DLLSYLA

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ALD6 CCT8 CYS4 ERG11 ERR3 HSP150 SLD2 TUB2 WAR1
    View Details Gavin AC, et al. (2006) CDC28 CKS1 CLN2 CYS4 NBA1 NIS1 SIC1 SSC1
    View Details Gavin AC, et al. (2002) ARX1 BEM2 BMS1 BRX1 BUD20 CIC1 CLU1 CYR1 CYS4 DBP10 DBP9 DCP2 DRS1 EBP2 ERB1 FPR4 GCN1 HAS1 HDA1 HER1 HIS3 INP2 IPI1 IPI3 KRE33 LHP1 LOC1 LSG1 MAK21 MAK5 MDN1 MIS1 MRT4 NAP1 NIP1 NIP7 NMD3 NOC2 NOC3 NOG1 NOG2 NOP1 NOP12 NOP15 NOP16 NOP2 NOP4 NOP56 NOP7 NSA1 NSA2 NUG1 PRT1 PUF6 REI1 RIX1 RIX7 RLP24 RLP7 RPA135 RPA190 RPF1 RPF2 RPG1 RPP2B RPT6 RRP1 RRP12 RSA3 RSA4 RTR1 SDA1 SEC7 SKI2 SNU13 SPB1 SPB4 SSC1 SSF1 TIF6 TUB3 URB1 UTP10 UTP20 UTP22 YGL036W YTM1
    View Details Ho Y, et al. (2002) AAC3 AAT2 ABP1 ACH1 ACO1 ADH6 AFR1 AHP1 AIM41 ARC1 ARF1 ARO1 ARP2 ARP4 ASA1 ATG17 ATG29 ATP3 ATP4 AVO1 BCY1 BEM3 BUD14 CAR2 CCR4 CCT2 CDC15 CDC33 CDC36 CDC39 CIC1 CIS1 CLU1 COF1 COR1 CPR1 CPR3 CRZ1 CYR1 CYS4 DCP1 DCP2 DIG1 DIG2 DNM1 DUG2 DUT1 EDC3 EDE1 EGD1 EGD2 ENP1 ERG13 ERG6 FOL2 FPR1 FRS2 GAS1 GCN3 GND1 GND2 GPH1 GRH1 GRX1 GSP1 GTO1 GUS1 HAP2 HAP5 HEF3 HHF1, HHF2 HOR2 HRR25 HSP104 HTB1 HXT7 HYP2 ILV5 IMD4 IPP1 KGD1 KSS1 LAA1 LOC1 LRO1 LSP1 LTV1 LYS1 MAM33 MDH1 MDS3 MET6 MGE1 MKK2 MKT1 MTC5 MTQ1 NAP1 NIP1 NMD5 NOP12 NOP16 NPA3 NSA1 NSA2 NTF2 NUG1 OLA1 OYE2 PEX19 PFK1 PGM2 PIL1 PIM1 PIN4 POL30 POL5 POP2 PRM2 PSE1 PTC4 PUF3 PUF6 RFA3 RHR2 RIO2 RLI1 RNQ1 RNR1 RNR2 RNR3 RPA135 RPC19 RPF2 RPM2 RPN12 RPN6 RPN9 RSN1 RVB1 SAH1 SAP185 SAP190 SAS10 SCP160 SEC2 SEC23 SEC53 SEN15 SES1 SFB3 SGM1 SIR1 SIR3 SIT4 SNO2 SNU13 SOD1 SPE3 SPT2 SRP1 SSF1 SSK2 SSN8 STE11 STE12 STE23 STI1 SUP45 TEC1 TEF4 TEM1 THI22 THO2 THS1 TIF1, TIF2 TIF4631 TIF6 TMA19 TMA29 TPK2 TPK3 TSA2 TSC11 TSR1 UBA1 UBR1 UTP22 UTP7 VMA4 VMA5 VPS21 WTM1 YBR028C YBR225W YCK1 YCK2 YCK3 YER138C YGL081W YGR066C YGR111W YJR141W YNK1 YNL134C YPT53 YRA1 YRA2 YTM1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run TOR1 No Comments Reinke A, et al. (2004)
    View Run PGA1 No Comments Hazbun TR, et al. (2003)
    View Run DAD1 Dam1 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run ASF1 3912: TAP-tagged, strain background includes hpc2(delta) Green EM, et al (2005)
    View Run RLF2 cac1: TAP-tagged Green EM, et al (2005)
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run DAD1 Dam1 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data CYS4 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..63]
    [157..368]    		 PSI-BLAST 1095.9897 Cystathionine beta-synthase
    2 View Details [64..156] PSI-BLAST 1095.9897 Cystathionine beta-synthase
    3 View Details [369..507] ORFEUS 14.2 Inosine monophosphate dehydrogenase (IMPDH)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • cysteine synthase activity
    		•  5.18562032111987 bayes_pls_golite062009
  • catalytic activity
    		•  2.38994231321972 bayes_pls_golite062009
  • lyase activity
    		•  1.87743897464083 bayes_pls_golite062009
  • cystathionine beta-synthase activity
    		•  1.4517088142802 bayes_pls_golite062009
  • tryptophan synthase activity
    		•  1.04832999357666 bayes_pls_golite062009
  • carbon-oxygen lyase activity
    		•  0.923824749425553 bayes_pls_golite062009
  • threonine synthase activity
    		•  0.727838845253199 bayes_pls_golite062009
  • ammonia-lyase activity
    		•  0.476674617721478 bayes_pls_golite062009
  • L-threonine ammonia-lyase activity
    		•  0.37325071016009 bayes_pls_golite062009
  • binding
    		•  0.362167982690705 bayes_pls_golite062009
  • carbon-nitrogen lyase activity
    		•  0.249761226675912 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle