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Protein Overview: RRP12

General Information:
Name(s) found: RRP12 / YPL012W [SGD]
Description(s) found:
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  • gi|965081|gb|AAB68093.1| Lpa5p [NCBI NR]
  • gi|74676637|sp|Q12754.1|RRP12_YEAST RecName: Full=Ribosomal RNA-processing protein 12 [NCBI NR]
  • gi|6325245|ref|NP_015313.1| Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; contains HEAT-repeats; Rrp12p [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S59681 probable membrane protein YPL012w - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • Ribosomal RNA-processing protein 12 OS=Saccharomyces cerevisiae GN=RRP12 PE=1 SV=1 [Swiss-Prot]
  • RRP12 Protein required for normal pre-rRNA Processing [mips]
  • Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; contains HEAT-repeats [SGD]
  • >Q12754 (Q12754) Hypothetical protein (LPA5P) [4932.FASTACCERV.txt]
  • Chr XVI from 529718-533404 [hmr_yeast5_DM3-1_pombe.fasta]
  • YPL012W, Chr XVI from 529718-533404 [yeast_orfs2]
  • RRP12 SGDID:S0005933, Chr XVI from 529718-533404, Verified ORF [yeastflysequest.fasta]
  • RRP12 SGDID:S0005933, Chr XVI from 529720-533406, Verified ORF [10112005cervSGD.fasta]
  • Protein required for normal pre-rRNA Processing; member of a group of seven genes whose expression is repressed during growth on glucose before and during the diauxic shift [Saccharomyces cerevisiae]gi|2132968|pir||S59681 probable membrane protein YPL012 [nrdb_11152004_Chlamydomonas]
  • (Q12754) Ypl012wp [cerv4932.FASTAC]
  • RRP12 SGDID:S000005933, Chr XVI from 529720-533406, Verified ORF, "Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; contains HEAT-repeats" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; contains HEAT-repeats; Rrp12p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Lpa5p [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • Ribosomal RNA-processing protein 12 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RRP12 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • RRP12 SGDID:S000005933, Chr XVI from 529723-533409, Genome Release 64-1-1, Verified ORF, "Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; has a role in nuclear import in association with Pse1p; contains HEAT-repeats" [yeast-030211-contam.fasta]
  • RRP12 SGDID:S000005933, Chr XVI from 529723-533409, Genome Release 64-2-1, Verified ORF, "Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; has a role in nuclear import in association with Pse1p; also plays a role in the cell cycle and the DNA damage response; contains HEAT-repeats" [20141208_orf_trans.fasta]
  • YPL012W SGDID:S000005933, Chr XVI from 529723-533409, Genome Release 64-1-1, Verified ORF, "Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; has a role in nuclear import in association with Pse1p; contains HEAT-repeats" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 1228 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    ribosome [TASLink to PubMed article]
    Biological Process: maturation of SSU-rRNA [TASLink to PubMed article]
    ribosome biogenesis [TASLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDQDKVAFLL ELEDKLAKIR SQVNSKLENQ KHIAIILTAV EENIAGQATN DVSKNIVNYI  60
   61 ISFMSLLDQA VDPSTHEIKD IQLASSSTYL LDLIFHYSPK VLLRSKFSEI LTKIAPCITA 120
  121 EKANAPLIRA AIGCLESLLI AQDAQAWNNT YDLNVTPKRG LQGILELSLD VRPKVRKRAL 180
  181 DAVHAVLLNP PVAPTAEHVA AVFVADFCDK QLAGILNDLS NLSNKQLKAQ KTKEDINASV 240
  241 MRSLRLITSV VSTGQWPSSQ IEPLCDVLLG VTKSSEQYLV SASFECFESM FKTMAETTIS 300
  301 SGLAENKYLR VLDTIFALKP SNVDTLLTKS WIAVVIKGMS TYATHQPLKA LRKIPGVFHI 360
  361 MCTYLASETP EVYQAASQCL ISILSESVKD DLLLYTPSVD EKVFKNVDEI ISQIAKTFID 420
  421 FLSIRYSHCS REILKILVAA FNKFRYRSNP HFLKSLKIVD TWRVNEEQFM DLRNEIELVI 480
  481 GASISAMGPE MILAEAPLNL DNPSSERPGR AWLLPLIRDY TKNANLATFQ NELAPYIKSF 540
  541 QSKFDKVPEE SIQLRVFQTI VDQIWSTLPR FCELPMDLRE SFTDEFASEL SSLLYSEVEL 600
  601 RTTICHALKV LAESNVSYAE ESSSHNVLLL QRFPISEAQK NIEYLSTKST NLLAVLFNVY 660
  661 TQTTPNARSY ILETIDQYLK ITSKEDLEKT FNNVCGLLKN SMNEESSGNV NKEKKKPQLT 720
  721 ATLLDLIICM ITYLPVSSYS ALFSMFSLTV NSADALIQKR AYRIITKLSE LKSGSTAVAQ 780
  781 FISDIENVMV DSASSVQTSA KAARLTAIKT IVELLPLDHL DFIVRTVAEV ILSTKDVNEK 840
  841 SRETAFDTLI CMGRKMNEPN GIIKLFQIPG YDPTTPDQSS SISEFFKIIS AGLIGESQHM 900
  901 VSSSITGYAC LVFEFKNELD SGILMDIYDT IELYLTSNSR EIVKSAIGFT KVCVLGLPEE 960
  961 LMRPKVPELL LKLLRWSHEH TGHFKAKVKH IIERLIRRFG YDYIEANFPE EDRRLLTNIR1020
 1021 KMRNRNKRKD EEVTTGVSDV AATKGSRFMS AFDEAVYGSD EENDNGSDQE ENVAGGKMKN1080
 1081 GAKQFIVESG DNPLDLLDSQ TLAHISSTRP KKFNKNQNRA RFNDDAFNFD SEGKLVVKGQ1140
 1141 PKPSTNVDDP LSAVTSGINA YLEAVKSGPV RGQRNKLKFR KNGKDSDEFG DDDDGEKDSR1200
 1201 LMRGRVNQGN KIGKHNKKGP KFKSRKKL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) BMS1 BRX1 CBF5 CIC1 DBP9 DIM1 DRS1 ECM16 EMG1 ENP1 ESF1 HAS1 HCA4 KRE33 KRI1 LTV1 MAK21 MPP10 NAN1 NOC2 NOC4 NOG1 NOP1 NOP12 NOP14 NOP2 NOP4 NOP53 NOP56 PNO1 PUF6 PWP1 RIO2 RLP7 RPF2 RPL5 RPS11A, RPS11B RPS13 RPS8B, RPS8A RPS9B RRP12 SLX9 TIF4632 TSR1 URB1 UTP10 UTP15 UTP20 UTP22 UTP7 UTP8 YTM1
    View Details Krogan NJ, et al. (2006) ACO1 BAT2 HSP42 NTH2 RRP12 SRS2 SSE2
    View Details Gavin AC, et al. (2002) AAR2 ADE4 ADH1 ARP9 ARX1 ASC1 BEM2 BFR2 BLM10 BMS1 BRX1 BUD20 BUD21 CBF5 CIC1 CKA1 CKA2 CKB1 CKB2 CLU1 CMS1 CYR1 CYS4 DAM1 DBP10 DBP8 DBP9 DCP2 DIA4 DIM1 DIP2 DIS3 DRS1 EBP2 ECM16 ECM29 EMG1 ENP1 ENP2 ERB1 ERO1 ESF1 ESF2 EST3 FAP7 FPR4 FUN12 GAR1 GCN1 GFA1 HAS1 HCA4 HDA1 HER1 HHF1, HHF2 HIS3 HRR25 HSL1 HTA2 IMP3 IMP4 INO4 INP2 IPI1 IPI3 KAP95 KRE33 KRR1 LCP5 LHP1 LOC1 LSG1 LTV1 LYS12 MAK21 MAK5 MDN1 MDS3 MIS1 MPP10 MRD1 MRP7 MRT4 MVD1 NAN1 NAP1 NHP2 NIP1 NIP7 NMD3 NOB1 NOC2 NOC3 NOC4 NOG1 NOG2 NOP1 NOP12 NOP14 NOP15 NOP16 NOP2 NOP4 NOP56 NOP58 NOP6 NOP7 NSA1 NSA2 NUD1 NUG1 PDA1 PDB1 PNO1 POL2 PRE10 PRE2 PRE3 PRE4 PRE5 PRE6 PRE8 PRE9 PRP4 PRP43 PRT1 PSE1 PUF6 PUP3 PWP2 RCL1 REI1 RGR1 RIO2 RIX1 RIX7 RLP24 RLP7 RML2 ROK1 RPA135 RPA190 RPF1 RPF2 RPG1 RPP2B RPT3 RPT5 RPT6 RRP1 RRP12 RRP7 RRP9 RSA3 RSA4 RTG2 RTR1 SAM1 SCL1 SDA1 SEC21 SEC7 SKI2 SLX9 SMB1 SNF12 SNF2 SNF5 SNF6 SNU114 SNU13 SNU66 SOF1 SPA2 SPB1 SPB4 SRO9 SRP1 SSF1 SWI1 SWI3 SWP82 TIF1, TIF2 TIF4631 TIF4632 TIF6 TSR1 TUB3 ULP1 URB1 UTP10 UTP11 UTP13 UTP15 UTP18 UTP20 UTP21 UTP22 UTP30 UTP4 UTP6 UTP7 UTP8 UTP9 VPS1 YFL006W YGL036W YGR054W YMR310C YOR059C YRA1 YTM1
    View Details Ho Y, et al. (2002) AIM46 ARE1 BMS1 BRX1 BUD3 CBF5 CBP2 CCM1 CCT2 CCT3 CCT6 CDC33 CDC53 CIC1 CIN8 CLU1 COF1 CTF4 DBP10 DBP7 DED81 DIA2 EBP2 ELA1 ENP1 ENP2 EST1 FET4 FPR3 FUN12 GBP2 GRS1 HAS1 HIR1 HMO1 HSH49 HTB1 HTB2 ILS1 IMD1 IMD2 IMD3 IMD4 ISA1 KRE33 KRI1 LST4 MAG2 MCM2 MCM3 MCM5 MGM101 MNP1 MRM1 MSC3 MSS116 NAN1 NIP7 NMD3 NOC2 NOG1 NOP1 NOP12 NOP4 NOP56 NOP6 NOP7 NPL3 OYE2 PDC6 PDI1 PET127 POL5 PRP43 PUF6 PWP1 RLI1 RPF2 RRP1 RRP12 RRP5 RVB1 SEH1 SKP1 SLT2 SPB1 SSD1 SSF1 SSF2 SSZ1 TIF4631 TIF4632 TIF6 TIS11 TMA19 TRA1 TSR1 URB1 URB2 UTP10 UTP20 UTP22 UTP7 YAK1 YBL104C YER077C YPP1 YRA1 YTM1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run BOI1 Sample boi 1 with ha tag from october 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi1 with gst from october 2005 McCusker D, et al (2007)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen SPT21 RRP12 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data RRP12 Huh WK, et al. (2003)

    Protein Structure Data

    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..168] deduced N/A No confident structure predictions are available.
    2 View Details [169..399] deduced N/A No confident structure predictions are available.
    3 View Details [400..508] deduced N/A No confident structure predictions are available.
    4 View Details [509..660] deduced N/A No confident structure predictions are available.
    5 View Details [661..733] MSA 1.278993 View MSA. No confident structure predictions are available.
    6 View Details [734..856] MSA 3.283996 View MSA. No confident structure predictions are available.
    7 View Details [857..1065] PSI-BLAST 35.045757 Constant regulatory domain of protein phosphatase 2a, pr65alpha
    8 View Details [1066..1228] MSA 1.028967 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle