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Protein Overview: NTH2

General Information:
Name(s) found: NTH2 / YBR001C [SGD]
Description(s) found:
Found 27 descriptions.
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  • Putative neutral trehalase, required for thermotolerance and may mediate resistance to other cellular stresses [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 780 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed article]
    Biological Process: trehalose catabolic process [TASLink to PubMed article]
    response to stress [TASLink to PubMed article]
    Molecular Function: alpha,alpha-trehalase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVDFLPKVTE INPPSEGNDG EDNIKPLSSG SEQRPLKEEG QQGGRRHHRR LSSMHEYFDP  60
   61 FSNAEVYYGP ITDPRKQSKI HRLNRTRTMS VFNKVSDFKN GMKDYTLKRR GSEDDSFLSS 120
  121 QGNRRFYIDN VDLALDELLA SEDTDKNHQI TIEDTGPKVI KVGTANSNGF KHVNVRGTYM 180
  181 LSNLLQELTI AKSFGRHQIF LDEARINENP VDRLSRLITT QFWTSLTRRV DLYNIAEIAR 240
  241 DSKIDTPGAK NPRIYVPYNC PEQYEFYIQA SQMNPSLKLE VEYLPKDITA EYVKSLNDTP 300
  301 GLLALAMEEH VNPSTGERSL VGYPYAVPGG RFNELYGWDS YLMALGLIES NKVDVARGMV 360
  361 EHFIFEIDHY SKILNANRSY YLCRSQPPFL TDMALLVFEK IGGKNNPNAI QLLKRAFRAA 420
  421 IKEYKEVWMS SPRLDSLTGL SCYHSDGIGI PPETEPDHFD TILLPYAEKY NVTLEKLRYL 480
  481 YNEGMIKEPK LDAFFLHDRA VRESGHDTTY RFEGVCAYLA TIDLNSLLYK YEKDIAFVIK 540
  541 EYFGNEYKDE NDGTVTDSEH WEELAELRKT RINKYMWDED SGFFFYYNTK LKCRTSYESA 600
  601 TTFWSLWAGL ATEEQAKITV EKALPQLEML GGLVACTEKS RGPISIDRPI RQWDYPFGWA 660
  661 PHQILAWKGL SAYGYQQVAT RLAYRWLYMI TKSFVDYNGM VVEKYDVTRG TDPHRVDAEY 720
  721 GNQGADFKGV ATEGFGWVNT SYLLGLKYMN NHARRALAAC SPPLPFFNSL KPSEKKLYYL 780
  781

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ACO1 BAT2 HSP42 NTH2 RRP12 SRS2 SSE2
    View Details Gavin AC, et al. (2002) BMH1 BMH2 NTH1 NTH2 PIK1 PSK1 RTG2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #02 Alpha Factor Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data NTH2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..120] deduced N/A No confident structure predictions are available.
    2 View Details [121..780] Pfam 1000.0 Trehalase No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • trehalase activity
    		•  4.96737734681829 bayes_pls_golite062009
  • alpha,alpha-trehalase activity
    		•  4.67585600835702 bayes_pls_golite062009
  • hydrolase activity, hydrolyzing O-glycosyl compounds
    		•  2.41255243910528 bayes_pls_golite062009
  • hydrolase activity, acting on glycosyl bonds
    		•  2.15795475185128 bayes_pls_golite062009
  • hydrolase activity
    		•  1.51256018302478 bayes_pls_golite062009
  • catalytic activity
    		•  1.16285856935495 bayes_pls_golite062009
  • binding
    		•  0.82501412375097 bayes_pls_golite062009
  • glucan 1,4-alpha-glucosidase activity
    		•  0.681871542272872 bayes_pls_golite062009
  • protein binding
    		•  0.31260719357226 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle