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Protein Overview: SRS2

General Information:
Name(s) found: SRS2 / YJL092W [SGD]
Description(s) found:
Found 31 descriptions.
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  • DNA helicase and DNA-dependent ATPase involved in DNA repair, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; blocks trinucleotide repeat expansion; affects genome stability [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1174 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ISSLink to PubMed article]
    Biological Process: DNA repair [IGILink to PubMed article]
    double-strand break repair via nonhomologous end joining [IDALink to PubMed article]
    Molecular Function: DNA helicase activity [IDALink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSNNDLWLH LVSQLNTQQR AAALFDYTRG LQVIAGPGTG KTKVLTSRVA YLILHHHIHP  60
   61 RDIIVTTFTN KAANEMKERL QEMLRGAGVN ISELLIGTFH SICLKILYRF GHLVDLQKDW 120
  121 RIIDEKEIDV ILDDMIEKVP DQIRDYASSI TRKVNLCMPS KNGDEWTIHP KLIKKQISKL 180
  181 KSNAILPEEY ILDSNHDAAL GYFYQIYQSE LSKKNTLDFD DLLMYTFRLL TRVRVLSNIK 240
  241 HVLVDEFQDT NGIQLDLMFL FAKGNHHLSR GMTIVGDPDQ SIYAFRNALA HNFLEMGRKC 300
  301 PIEYSTIILV ENYRSSQKIL NTSEILITQQ NKGRQNRAPL RAQFDLDFPP VYMNFPAYFL 360
  361 EAPSLVRELL YLKALPNLFT FNDFAILVRQ RRQIKRIESA LIEHRIPYKI IRGHSFWDSK 420
  421 ETRAMLNLLK LIFSPNDKHA ILASLLYPAR GLGPATGEKI KNALDTLATD VSCFQILKDI 480
  481 SSKKIMLDIP TKGRSVIADF ISMIENCQLL LQSTLLGGLS DLFDKLYELS GLKYEYLYKD 540
  541 GKKKNDQLEK SEPNLLNARH KNIELLKNYF LALLSKSESS DKEKNEAIKA ATDEAEPIEN 600
  601 KVITPKEYLR NFFNSLSLHS DAAEEEESES NKDAKIKREK NGFVTISTIH GAKGLEWPVV 660
  661 FIPGCEEGII PCVFNDDKKD ESEEDEEEDQ ENSKKDASPK KTRVLSVEDS IDEERRMFFV 720
  721 AQTRAKYLLY LSNTVTVEDV DRPRIASRFL TTDLIKAMSD SQKLFESTNS IKKLYRILNK 780
  781 KPPAEDDKLF SLDQLRKDYN QFIENRRERM IWQGIQMNDV YGIQLSRNKL LGSVSDFTSA 840
  841 ADQLRLETQN SIFPQKKLIE KSRPSKINGN YAPKSRVKSP EKRYAPETTS FHSPTKKKVY 900
  901 APQYVSTTNV PSRQEFHSST GKNIPFLRRE DRSITDISPR SSTRSLKGAS PNKTSHMSDD 960
  961 LMRPSPTRKD KVTRNIHFAT AGTFRIETQS NVDELHPPEY SNKSGQSLTS SEFSGFSSAC1020
 1021 SNSDQPTNLI EDINNELDLS DEELLNDISI ERRRELLGSK KTKKIKPKTR NRKSKRGDKV1080
 1081 KVEEVIDLKS EFEEDDSRNT TAAELLHNPD DTTVDNRPII SNAKFLADAA MKKTQKFSKK1140
 1141 VKNEPASSQM DIFSQLSRAK KKSKLNNGEI IVID

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ACO1 BAT2 HSP42 NTH2 RRP12 SRS2 SSE2
    View Details Ho Y, et al. (2002) DUN1 SEC23 SEC53 SRS2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CAB3 No Comments Hazbun TR, et al. (2003)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #14 Mitotic Prep2-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SRS2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..313] PSI-BLAST 715.9691 DEXX box DNA helicase
    2 View Details [314..839] PSI-BLAST 715.9691 DEXX box DNA helicase
    3 View Details [840..1174] ORFEUS 10.98 Fibrinogen

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  2.44689197844883 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  1.5002869400376 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  1.49611313354225 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  1.47468810672455 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  1.47371190790284 bayes_pls_golite062009
  • hydrolase activity
    		•  1.29419296935491 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  1.2155186842031 bayes_pls_golite062009
  • helicase activity
    		•  1.16085745407703 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.08697924060619 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • ATPase activity
    		•  0.844502974582959 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.72881469450553 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.720649395550746 bayes_pls_golite062009
  • DNA binding
    		•  0.702147676354075 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  0.59513742813869 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  0.59513742813869 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.58862275163252 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.287777990975748 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  0.22150712609541 bayes_pls_golite062009
  • nucleotide binding
    		•  0.114848452385726 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.10713474095071 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.0916519414118148 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.0915913646217636 bayes_pls_golite062009
  • protein binding
    		•  0.071010918255742 bayes_pls_golite062009
    2
    Term Confidence Notes
  • binding
    		•  2.44689197844883 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  1.5002869400376 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  1.49611313354225 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  1.47468810672455 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  1.47371190790284 bayes_pls_golite062009
  • hydrolase activity
    		•  1.29419296935491 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  1.2155186842031 bayes_pls_golite062009
  • helicase activity
    		•  1.16085745407703 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.08697924060619 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • ATPase activity
    		•  0.844502974582959 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.72881469450553 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.720649395550746 bayes_pls_golite062009
  • DNA binding
    		•  0.702147676354075 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  0.59513742813869 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  0.59513742813869 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.58862275163252 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.287777990975748 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  0.22150712609541 bayes_pls_golite062009
  • nucleotide binding
    		•  0.114848452385726 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.10713474095071 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.0916519414118148 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.0915913646217636 bayes_pls_golite062009
  • protein binding
    		•  0.071010918255742 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.82

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle