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Protein Overview: PRP43

General Information:
Name(s) found: PRP43 / YGL120C [SGD]
Description(s) found:
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  • gi|6321318|ref|NP_011395.1| RNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript metabolism, involved in release of the lariat-intron from the spliceosome; Prp43p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|2623343|gb|AAB86458.1| Prp43p [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S64130 PRP22 protein homolog YGL120c - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1723910|sp|P53131.1|PRP43_YEAST RecName: Full=Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43; AltName: Full=Helicase JA1 [NCBI NR]
  • gi|1322677|emb|CAA96828.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43 OS=Saccharomyces cerevisiae GN=PRP43 PE=1 SV=1 [Swiss-Prot]
  • (P53131) Pre-mRNA splicing factor RNA helicase PRP43 (Helicase JA1) [Swiss-Prot]
  • PRP43 Protein involved in spliceosome disassembly [mips]
  • RNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript metabolism, involved in release of the lariat-intron from the spliceosome [SGD]
  • PRP43, Chr VII from 281635-283938, reverse complement [yeast_orfs2]
  • Chr VII from 281635-283938, reverse complement [yeastorf3.fasta]
  • Chr VII from 281638-283941, reverse complement [yeastorf4.fasta]
  • Chr VII from 283941-281638, reverse complement [yeastorf5.fasta]
  • PRP43 SGDID:S0003088, Chr VII from 283941-281638, reverse complement, Verified ORF [yeastflysequest.fasta]
  • PRP43 SGDID:S0003088, Chr VII from 283943-281640, reverse complement, Verified ORF [10112005cervSGD.fasta]
  • Prp43p [Saccharomyces cerevisiae]gi|1322677|emb|CAA96828.1| unnamed protein product [Saccharomyces cerevisiae]gi|2133074|pir||S64130 PRP22 protein homolog YGL120c - yeast (Saccharomyces cerevisiae)gi|2623343|gb|AAB86458.1| Prp43p [Saccharomyces cerevis [nrdb_11152004_Chlamydomonas]
  • PRP43 SGDID:S000003088, Chr VII from 283943-281640, reverse complement, Verified ORF, "RNA helicase in the DEAH-box family, involved in release of the lariat-intron from the spliceosome" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • PRP43 SGDID:S000003088, Chr VII from 283943-281640, reverse complement, Verified ORF, "RNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript metabolism, involved in release of the lariat-intron from the splic [yeast-contam.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • RNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript metabolism, involved in release of the lariat-intron from the spliceosome; Prp43p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43 (Helicase JA1) [nr-271106-contam.fasta]
  • Prp43p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • PRP43 SGDID:S000003088, Chr VII from 283943-281640, reverse complement, Verified ORF, "RNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript metabolism, involved in release of the lariat-intron from the spliceosome" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PRP43 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • PRP43 SGDID:S000003088, Chr VII from 283937-281634, Genome Release 64-1-1, reverse complement, Verified ORF, "RNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript metabolism, involved in release of the lariat-intron from the spliceosome" [yeast-030211-contam.fasta]
  • PRP43 SGDID:S000003088, Chr VII from 283937-281634, Genome Release 64-2-1, reverse complement, Verified ORF, "RNA helicase in the DEAH-box family; functions in both RNA polymerase I and polymerase II transcript metabolism; catalyzes removal of U2, U5, and U6 snRNPs from the postsplicing lariat-intron ribonucleoprotein complex; required for efficient biogenesis of both small- and large-subunit rRNAs; acts with Sqs1p to promote 20S to 18S rRNA processing catalyzed by endonuclease Nob1p" [20141208_orf_trans.fasta]
  • TR7977|c0_g1_i1|g.5526 ORF TR7977|c0_g1_i1|g.5526 TR7977|c0_g1_i1|m.5526 type:complete len:768 (+) TR7977|c0_g1_i1:117-2420(+) [Y12_S_cerevisiae-Sep2015-contam.fasta]
  • YGL120C SGDID:S000003088, Chr VII from 283937-281634, Genome Release 64-1-1, reverse complement, Verified ORF, "RNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript metabolism, involved in release of the lariat-intron from the spliceosome" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
  • ID=asmbl_2046|g.1183 ORF ID=asmbl_2046|g.1183 ID=asmbl_2046|m.1183 type:complete len:768 (+) ID=asmbl_2046:113-2416(+) [Y12_quiver_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 767 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed article]
    spliceosomal complex [TASLink to PubMed article]
    nuclear outer membrane [IMPLink to PubMed article]
    Biological Process: maturation of SSU-rRNA [IMPLink to PubMed article]
    ribosomal large subunit biogenesis [IMPLink to PubMed article]
    ribosome biogenesis [RCALink to PubMed article]
    rRNA processing [IMPLink to PubMed articleLink to PubMed article]
    processing of 27S pre-rRNA [IMPLink to PubMed article]
    Molecular Function: ATP-dependent RNA helicase activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGSKRRFSSE HPDPVETSIP EQAAEIAEEL SKQHPLPSEE PLVHHDAGEF KGLQRHHTSA  60
   61 EEAQKLEDGK INPFTGREFT PKYVDILKIR RELPVHAQRD EFLKLYQNNQ IMVFVGETGS 120
  121 GKTTQIPQFV LFDEMPHLEN TQVACTQPRR VAAMSVAQRV AEEMDVKLGE EVGYSIRFEN 180
  181 KTSNKTILKY MTDGMLLREA MEDHDLSRYS CIILDEAHER TLATDILMGL LKQVVKRRPD 240
  241 LKIIIMSATL DAEKFQRYFN DAPLLAVPGR TYPVELYYTP EFQRDYLDSA IRTVLQIHAT 300
  301 EEAGDILLFL TGEDEIEDAV RKISLEGDQL VREEGCGPLS VYPLYGSLPP HQQQRIFEPA 360
  361 PESHNGRPGR KVVISTNIAE TSLTIDGIVY VVDPGFSKQK VYNPRIRVES LLVSPISKAS 420
  421 AQQRAGRAGR TRPGKCFRLY TEEAFQKELI EQSYPEILRS NLSSTVLELK KLGIDDLVHF 480
  481 DFMDPPAPET MMRALEELNY LACLDDEGNL TPLGRLASQF PLDPMLAVML IGSFEFQCSQ 540
  541 EILTIVAMLS VPNVFIRPTK DKKRADDAKN IFAHPDGDHI TLLNVYHAFK SDEAYEYGIH 600
  601 KWCRDHYLNY RSLSAADNIR SQLERLMNRY NLELNTTDYE SPKYFDNIRK ALASGFFMQV 660
  661 AKKRSGAKGY ITVKDNQDVL IHPSTVLGHD AEWVIYNEFV LTSKNYIRTV TSVRPEWLIE 720
  721 IAPAYYDLSN FQKGDVKLSL ERIKEKVDRL NELKQGKNKK KSKHSKK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) AIR2 BRR2 BUD31 CDC40 CLF1 CWC2 CWC22 CWC23 ECM16 ECM2 FUN12 GBP2 HSH155 KEM1 KRE33 LEA1 MAK5 MTR4 NOP1 NOP56 NOP58 NSR1 NTR2 PAP2 PRP19 PRP43 PRP46 PRP8 PWP1 RPL15A RPS13 RPS4B, RPS4A RPS7A RPS8B, RPS8A RSE1 SNT309 SNU114 SPP382 SQS1 SRO9 STM1 STO1 SYF1 TSR1 UTP22 YGR054W
    View Details Hazbun TR, et al. (2003) BRR2 CDC40 CEF1 CLF1 CWC2 CWC22 CWC23 ECM2 ISY1 LEA1 NTR2 PRP19 PRP43 PRP45 PRP46 PRP8 SMB1 SMD1 SMD3 SMX3 SNT309 SNU114 SPP382 SYF1 SYF2 YJU2
    View Details (MIPS) Mewes HW, et al. (2004) AAR2 BRR1 BRR2 CBC2 CDC40 CWC15 CWC2 CWC22 CWC23 DHR2 LSM4 MAK5 MUD2 PRP16 PRP18 PRP2 PRP22 PRP24 PRP28 PRP31 PRP38 PRP39 PRP4 PRP40 PRP43 PRP5 PRP6 PRP8 SLU7 SMD1 SMD3 SME1 SNP1 SPP2 SPP381 STO1 YHC1
    View Details Krogan NJ, et al. (2006) CWC23 PRP43 SPP382 SQS1
    View Details Gavin AC, et al. (2006) PRP43 SQS1
    View Details Gavin AC, et al. (2002) AAR2 ACK1 ADE4 ASC1 ATG26 AVO1 BEM2 BFR2 BMS1 BRR1 BRX1 BUD21 BUD3 BUD31 CBC2 CBF5 CDC33 CDC40 CEF1 CEG1 CET1 CFT2 CKA1 CKA2 CKB1 CKB2 CLF1 CLU1 CMS1 COP1 CSN12 CTR9 CUS1 CWC2 CWC22 CWC23 CYR1 DBP8 DCP2 DHH1 DIA4 DIB1 DIM1 DIP2 DIS3 ECM16 ECM2 ECM29 EMG1 ENP1 ENP2 ERB1 ERO1 ESF1 ESF2 FAP7 FIP1 GCN1 GCN2 GLC7 HAS1 HCA4 HHF1, HHF2 HRR25 HRT1 HSH155 HSH49 HSL1 HTA1 HTA2 IMG1 IMG2 IML1 IMP3 IMP4 IPP1 ISY1 KRE33 KRR1 KRS1 LCP5 LEA1 LIN1 LSM1 LSM12 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 LTV1 LUC7 MHR1 MPP10 MRD1 MRH4 MRM1 MRP20 MRP49 MRP7 MRPL1 MRPL10 MRPL13 MRPL16 MRPL17 MRPL19 MRPL20 MRPL23 MRPL24 MRPL25 MRPL27 MRPL28 MRPL3 MRPL35 MRPL36 MRPL38 MRPL39 MRPL4 MRPL44 MRPL51 MRPL6 MRPL7 MRPL8 MRPS5 MSL1 MUD1 MVD1 NAM7 NAM8 NAN1 NIP1 NOB1 NOC2 NOC4 NOG2 NOP1 NOP12 NOP14 NOP56 NOP58 NOP6 NPL3 NUG1 PAP1 PAT1 PDB1 PFS2 PNO1 PPA2 PRE6 PRE9 PRP11 PRP18 PRP19 PRP2 PRP21 PRP22 PRP24 PRP28 PRP3 PRP31 PRP38 PRP39 PRP4 PRP40 PRP42 PRP43 PRP45 PRP46 PRP6 PRP8 PRP9 PTA1 PTI1 PWP2 RCL1 REF2 RET2 RML2 RNA14 ROK1 ROM2 RPG1 RPP2B RRP12 RRP7 RRP9 RSE1 RTC6 RTG2 RVB2 SAM1 SCL1 SEC1 SEC21 SEC26 SEC27 SIN4 SLU7 SLX9 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNF2 SNP1 SNT309 SNU114 SNU23 SNU56 SNU66 SNU71 SOF1 SPP381 SPP382 SPT16 SQS1 SRB2 SRO9 SSA3 SSA4 STO1 SWI3 SYF1 SYP1 TAF5 TIF1, TIF2 TIF4631 TIF4632 TOP2 TOS4 TSR1 TUS1 UTP10 UTP11 UTP13 UTP15 UTP18 UTP20 UTP21 UTP22 UTP30 UTP4 UTP6 UTP7 UTP8 UTP9 VPS1 YDR115W YEF3 YML6 YOR059C YPL066W YSH1
    View Details Ho Y, et al. (2002) ACO1 AFG2 ALB1 ARX1 ASC1 BUD20 CBF5 CBP2 CCM1 CCT6 CDC14 CDC33 CIC1 DBP7 EGD2 EHD3 ENP2 ERB1 FYV4 GBP2 GND1 GUS1 HAS1 HHF1, HHF2 HMO1 HTA1 HTB1 HTB2 HXT7 IMD1 IMD3 ISA1 KRE33 KRI1 LHP1 MAM33 MET6 MGM101 MNP1 MRPS16 MRT4 MSS116 MUB1 NMD3 NOB1 NOC2 NOC3 NOG1 NOP12 NOP13 NOP56 NOP6 NOP7 NPL3 NSA1 NSA2 NUG1 PET127 POL5 PRP43 PUF6 PWP1 RFA1 RIX1 RLI1 RRP12 RRP5 RSM24 RSM25 SAH1 SCS2 SEC53 SPB4 SSQ1 TIF4631 TIF6 TRA1 TSR1 UBR2 URB1 URB2 UTP10 UTP20 YBL044W YPP1 YRA1 YTM1
    View Details Qiu et al. (2008) AAR2 BRR1 BRR2 BUD31 CBC2 CDC40 CEF1 CLF1 CUS1 CUS2 CWC15 CWC2 CWC22 CWC23 CWC25 DBP3 DBP6 DBP7 DBP8 DHR2 DIB1 DRS1 ECM2 GAR1 HAS1 HCA4 HSH155 ISY1 LEA1 LSM2 LSM4 LSM5 LSM7 LUC7 MAK5 MSL1 MSL5 MUD1 MUD2 NAM8 NOP13 NSR1 NTC20 NUG1 PAB1 PRP11 PRP16 PRP18 PRP19 PRP2 PRP21 PRP22 PRP24 PRP28 PRP3 PRP31 PRP38 PRP39 PRP4 PRP40 PRP42 PRP43 PRP5 PRP6 PRP8 PRP9 PWP2 RSE1 SLU7 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNP1 SNT309 SNU114 SNU23 SNU56 SNU66 SNU71 SOF1 SPB4 SPP2 SPP381 SPP382 STO1 SUB2 SYF1 SYF2 UTP13 UTP15 UTP6 YHC1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CWC2 No Comments Hazbun TR, et al. (2003)
    View Run SPP382 No Comments Hazbun TR, et al. (2003)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #04 Alpha Factor Prep2 Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen SPP382 PRP43 2 Hazbun TR, et al. (2003)

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PRP43 Huh WK, et al. (2003)
    View Data PRP43 and NOP56 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..70] deduced N/A No confident structure predictions are available.
    2 View Details [71..273] PSI-BLAST 61.69897 Putative DEAD box RNA helicase
    3 View Details [274..453] PSI-BLAST 61.69897 Putative DEAD box RNA helicase
    4 View Details [454..523] ORFEUS 7.23 delta subunit; delta subunit of DNA polymerase III, N-domain
    5 View Details [524..666] ORFEUS 7.23 delta subunit; delta subunit of DNA polymerase III, N-domain
    6 View Details [667..767] MSA 3.157986 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle