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Protein Overview: PPA2

General Information:
Name(s) found: PPA2 / YMR267W [SGD]
Description(s) found:
Found 23 descriptions.
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  • Mitochondrial inorganic pyrophosphatase, required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 310 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed article][IMPLink to PubMed article]
    Biological Process: aerobic respiration [IMPLink to PubMed article]
    Molecular Function: inorganic diphosphatase activity [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNLLRMNALT SKARSIERLK QTLNILSIRN HRQFSTIQQG SKYTLGFKKY LTLLNGEVGS  60
   61 FFHDVPLDLN EHEKTVNMIV EVPRWTTGKF EISKELRFNP IVQDTKNGKL RFVNNIFPYH 120
  121 GYIHNYGAIP QTWEDPTIEH KLGKCDVALK GDNDPLDCCE IGSDVLEMGS IKKVKVLGSL 180
  181 ALIDDGELDW KVIVIDVNDP LSSKIDDLEK IEEYFPGILD TTREWFRKYK VPAGKPLNSF 240
  241 AFHEQYQNSN KTIQTIKKCH NSWKNLISGS LQEKYDNLPN TERAGNGVTL EDSVKPPSQI 300
  301 PPEVQKWYYV

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Gavin AC, et al. (2002) ACK1 IPP1 PPA2 PRP43 ROM2 TUS1 YPL066W

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data PPA2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..310] PSI-BLAST 832.38764 Inorganic pyrophosphatase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • inorganic diphosphatase activity
    		•  2.74116819406619 bayes_pls_golite062009
  • binding
    		•  1.77492613217844 bayes_pls_golite062009
  • catalytic activity
    		•  1.33262120571864 bayes_pls_golite062009
  • hydrolase activity
    		•  0.715768350203578 bayes_pls_golite062009
  • protein binding
    		•  0.38607803003281 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle