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Protein Overview: KAP123

General Information:
Name(s) found: KAP123 / YER110C [SGD]
Description(s) found:
Found 24 descriptions.
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  • Karyopherin beta, mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and import of histones H3 and H4; localizes to the nuclear pore, nucleus, and cytoplasm; exhibits genetic interactions with RAI1 [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1113 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed articleLink to PubMed article]
    nuclear pore [IDALink to PubMed article]
    Biological Process: protein import into nucleus [TASLink to PubMed article]
    Molecular Function: protein transmembrane transporter activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDQQFLSQLE QTLHAITSGV GLKEATKTLQ TQFYTQPTTL PALIHILQNG SDDSLKQLAG  60
   61 VEARKLVSKH WNAIDESTRA SIKTSLLQTA FSEPKENVRH SNARVIASIG TEELDGNKWP 120
  121 DLVPNLIQTA SGEDVQTRQT AIFILFSLLE DFTSSLSGHI DDFLALFSQT INDPSSLEIR 180
  181 SLSAQALNHV SALIEEQETI NPVQAQKFAA SIPSVVNVLD AVIKADDTMN AKLIFNCLND 240
  241 FLLLDSQLTG NFIVDLIKLS LQIAVNSEID EDVRVFALQF IISSLSYRKS KVSQSKLGPE 300
  301 ITVAALKVAC EEIDVDDELN NEDETGENEE NTPSSSAIRL LAFASSELPP SQVASVIVEH 360
  361 IPAMLQSANV FERRAILLAI SVAVTGSPDY ILSQFDKIIP ATINGLKDTE PIVKLAALKC 420
  421 IHQLTTDLQD EVAKFHEEYL PLIIDIIDSA KNIVIYNYAT VALDGLLEFI AYDAIAKYLD 480
  481 PLMNKLFYML ESNESSKLRC AVVSAIGSAA FAAGSAFIPY FKTSVHYLEK FIQNCSQIEG 540
  541 MSEDDIELRA NTFENISTMA RAVRSDAFAE FAEPLVNSAY EAIKTDSARL RESGYAFIAN 600
  601 LAKVYGENFA PFLKTILPEI FKTLELDEYQ FNFDGDAEDL AAFADSANEE ELQNKFTVNT 660
  661 GISYEKEVAS AALSELALGT KEHFLPYVEQ SLKVLNEQVD ESYGLRETAL NTIWNVVKSV 720
  721 LLASKVEPES YPKGIPASSY VNADVLAVIQ AARETSMGNL SDEFETSMVI TVMEDFANMI 780
  781 KQFGAIIIMD NGDSSMLEAL CMQVLSVLKG THTCQTIDIE EDVPRDEELD ASETEATLQD 840
  841 VALEVLVSLS QALAGDFAKV FDNFRPVVFG LFQSKSKNKR SSAVGAASEL ALGMKEQNPF 900
  901 VHEMLEALVI RLTSDKSLEV RGNAAYGVGL LCEYASMDIS AVYEPVLKAL YELLSAADQK 960
  961 ALAAEDDEAT REIIDRAYAN ASGCVARMAL KNSALVPLEQ TVPALLAHLP LNTGFEEYNP1020
 1021 IFELIMKLYQ ENSPVITNET PRIIEIFSAV FTKENDRIKL EKESTLGREE NMERLKQFQT1080
 1081 EEMKHKVIEL LKYLNTTYNG IVAQNPVLAA VIA

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CSR1 KAP123
    View Details Hazbun TR, et al. (2003) ADH1 KAP123 MIA40 TOM40
    View Details Krogan NJ, et al. (2006) FUN19 KAP123 YMR290W-A YNL122C
    View Details Gavin AC, et al. (2006) FUN19 KAP123 YPR174C
    View Details Gavin AC, et al. (2002) ACC1 ACT1 ADA2 ADH1 ARO1 ARX1 ATP2 BCP1 BDF2 BMH1 BMH2 CAM1 CCT4 CCT8 CDC55 CKB1 CLU1 CPA2 CRM1 CRN1 CSE1 DHH1 DUG1 DYN1 ECM1 ECM29 ECM5 EFB1 EMP24 ERP1 ERP2 ERV25 FAP1 FDH1 FET5 FKS1 FTH1 FUN19 GCN1 GCN20 GCN5 GEA2 GFA1 GLT1 GLY1 GUS1 HAS1 HAT1 HAT2 HEM13 HHF1, HHF2 HIF1 HRP1 HSC82 HSM3 HSP42 ICL1 IDH2 ILV1 IML1 IRR1 KAP104 KAP114 KAP123 KGD1 KGD2 KRE33 KTR3 LCB1 LCB2 LEA1 LIP2 LPD1 LYS12 LYS2 MAC1 MCD1 MDN1 MEC1 MED4 MES1 MGA2 MIP6 MIR1 MIS1 MKT1 MLC1 MLC2 MNN4 MOT1 MRPL23 MRPL3 MSB1 MYO1 MYO2 MYO4 NAB2 NAB3 NAB6 NEW1 NGG1 NIP1 NIP7 NMD5 NOC2 NOP1 NOP12 NRD1 NSL1 OLA1 PDC1 PFK1 PFK2 PHB1 PRO1 PRP11 PRT1 PSA1 PSD2 PSE1 PSH1 PSK1 PTC1 PUF6 RAD51 RAD52 RFA1 RGR1 RKM1 ROM2 RPA135 RPB2 RPC40 RPG1 RPN10 RPN11 RPN12 RPN3 RPN6 RPN8 RPN9 RPO21 RPT2 RPT3 RPT5 RPT6 RRP1 RSC3 RVB2 SAM1 SAM2 SBP1 SCC4 SEC27 SEC7 SEN54 SGF29 SGF73 SHE2 SHE3 SIN3 SIN4 SLC1 SMC1 SMC3 SPT15 SPT20 SPT7 SPT8 SRV2 SSA4 SUI3 SUP35 SUP45 SXM1 TAF1 TAF10 TAF11 TAF12 TAF13 TAF14 TAF2 TAF3 TAF4 TAF5 TAF6 TAF7 TAF8 TAF9 TAO3 TAT1 TBF1 TCB1 TEF1, TEF2 TEF4 TEL1 TFP1 TIF1, TIF2 TSA1 TSC11 TUB3 URA7 USO1 UTP20 VAC14 VAS1 VPS1 VPS5 VTH2 YEF3 YFR006W YHB1 YHR020W YJL017W YMR31 YNL313C YOL098C YPR077C
    View Details Qiu et al. (2008) KAP120 KAP122 KAP123 KAP95 MLP1 NTF2 NUP1 NUP100 NUP116 NUP120 NUP145 NUP157 POM152 SUS1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run TOR1 No Comments Reinke A, et al. (2004)
    View Run BIR1 No Comments Widlund PO, et al. (2005)
    View Run YNL313C No Comments Hazbun TR, et al. (2003)
    View Run CAB4 No Comments Hazbun TR, et al. (2003)
    View Run MIA40 No Comments Hazbun TR, et al. (2003)
    View Run TIM50 No Comments Hazbun TR, et al. (2003)
    View Run NOP9 No Comments Hazbun TR, et al. (2003)
    View Run PGA1 No Comments Hazbun TR, et al. (2003)
    View Run MIA40 No Comments Hazbun TR, et al. (2003)
    View Run GWT1 No Comments Hazbun TR, et al. (2003)
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #13 Mitotic Prep2-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data KAP123 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..238] PSI-BLAST 99.228787 Importin beta
    2 View Details [239..428] PSI-BLAST 99.228787 Importin beta
    3 View Details [429..523] PSI-BLAST 99.228787 Importin beta
    4 View Details [524..749] PSI-BLAST 99.228787 Importin beta
    5 View Details [750..898] ORFEUS 14.16 Adaptin beta subunit N-terminal fragment
    6 View Details [899..1113] ORFEUS 14.16 Adaptin beta subunit N-terminal fragment

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein transporter activity
    		•  4.58709163830613 bayes_pls_golite062009
  • protein transmembrane transporter activity
    		•  2.74547353635661 bayes_pls_golite062009
  • binding
    		•  2.61658111885029 bayes_pls_golite062009
  • transporter activity
    		•  2.48700774379895 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  2.26725422172281 bayes_pls_golite062009
  • protein binding
    		•  2.13529412360404 bayes_pls_golite062009
  • nuclear localization sequence binding
    		•  1.91487015967262 bayes_pls_golite062009
  • nuclear export signal receptor activity
    		•  1.29390474721722 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.28481004323799 bayes_pls_golite062009
  • RNA binding
    		•  1.20550543134698 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.09652988954158 bayes_pls_golite062009
  • signal sequence binding
    		•  0.57106697498903 bayes_pls_golite062009
  • structural molecule activity
    		•  0.449804281824548 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.252495966234234 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.248585912061178 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.226380819487924 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  0.217517113570989 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  0.178770060806735 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  0.175241020572885 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  0.174922130116569 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.169755106399802 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.100181463251306 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.0635404099346928 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.0548082069333885 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.052195223119721 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.0405268469927988 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.84

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle