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Protein Overview: CSR1

General Information:
Name(s) found: CSR1 / YLR380W [SGD]
Description(s) found:
Found 26 descriptions.
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  • Phosphatidylinositol transfer protein with a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 408 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    microsome [IDALink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: cellular cell wall organization [IGILink to PubMed article]
    phospholipid transport [IDALink to PubMed article]
    ER-associated protein catabolic process [IMPLink to PubMed article]
    Molecular Function: phosphatidylinositol transporter activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFDRQLTED QEVVLKQIWT HLFHLWQVPV DGTHIFPNNS LHSSSTPAKK KKSSWFSKLQ  60
   61 SSDHTQDSSE AAEAAHLYEK GKIHKALANL DPQTTKKQFW HDIKNETPDA TILKFIRARK 120
  121 WNADKTIAML GHDLYWRKDT INKIINGGER AVYENNETGV IKNLELQKAT IQGYDNDMRP 180
  181 VILVRPRLHH SSDQTEQELE KFSLLVIEQS KLFFKENYPA STTILFDLNG FSMSNMDYAP 240
  241 VKFLITCFEA HYPESLGHLL IHKAPWIFNP IWNIIKNWLD PVVASKIVFT KNIDELHKFI 300
  301 QPQYIPRYLG GENDNDLDHY TPPDGSLDVH LKDTETRAMI EKEREELVEQ FLTVTAQWIE 360
  361 HQPLNDPAYI QLQEKRVQLS TALCENYSKL DPYIRSRSVY DYNGSLKV

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CHA1 CSR1 KAP123 RPL8B RPS0A SEC65
    View Details Krogan NJ, et al. (2006) CSR1 TYW1
    View Details Qiu et al. (2008) CSR1 FAT1 SFH5

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data CSR1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..52] deduced N/A No confident structure predictions are available.
    2 View Details [53..134] PSI-BLAST 127.9897 N-terminal domain of phosphatidylinositol transfer protein sec14p; C-terminal domain of phosphatidylinositol transfer protein sec14p
    3 View Details [135..408] PSI-BLAST 127.9897 N-terminal domain of phosphatidylinositol transfer protein sec14p; C-terminal domain of phosphatidylinositol transfer protein sec14p

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phospholipid transporter activity
    		•  4.82372291869245 bayes_pls_golite062009
  • lipid transporter activity
    		•  3.44932625048477 bayes_pls_golite062009
  • phosphatidylinositol transporter activity
    		•  3.08477039249457 bayes_pls_golite062009
  • binding
    		•  2.07778268514777 bayes_pls_golite062009
  • transporter activity
    		•  1.52591056865451 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.36272499520472 bayes_pls_golite062009
  • vitamin binding
    		•  1.07146133708197 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.658164745879483 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.387752763420225 bayes_pls_golite062009
  • protein binding
    		•  0.385179389448981 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle