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Protein Overview: CHA1

General Information:
Name(s) found: CHA1 / YCL064C [SGD]
Description(s) found:
Found 24 descriptions.
SHOW ALL
  • Catabolic L-serine (L-threonine) deaminase, catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 360 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed article]
    mitochondrial nucleoid [IDALink to PubMed article]
    Biological Process: threonine catabolic process [IMPLink to PubMed article]
    serine family amino acid catabolic process [IMPLink to PubMed article]
    Molecular Function: L-serine ammonia-lyase activity [IMPLink to PubMed article][ISSLink to PubMed article]
    L-threonine ammonia-lyase activity [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSIVYNKTPL LRQFFPGKAS AQFFLKYECL QPSGSFKSRG IGNLIMKSAI RIQKDGKRSP  60
   61 QVFASSGGNA GFAAATACQR LSLPCTVVVP TATKKRMVDK IRNTGAQVIV SGAYWKEADT 120
  121 FLKTNVMNKI DSQVIEPIYV HPFDNPDIWE GHSSMIDEIV QDLKSQHISV NKVKGIVCSV 180
  181 GGGGLYNGII QGLERYGLAD RIPIVGVETN GCHVFNTSLK IGQPVQFKKI TSIATSLGTA 240
  241 VISNQTFEYA RKYNTRSVVI EDKDVIETCL KYTHQFNMVI EPACGAALHL GYNTKILENA 300
  301 LGSKLAADDI VIIIACGGSS NTIKDLEEAL DSMRKKDTPV IEVADNFIFP EKNIVNLKSA 360
  361

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CHA1 CSR1
    View Details Krogan NJ, et al. (2006) CHA1 SDA1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run KIP3 No Comments Cheeseman IM, et al. (2002)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data CHA1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..30]
    [152..360]    		 PSI-BLAST 201.502279 Allosteric threonine deaminase N-terminal domain; Allosteric threonine deaminase C-terminal domain
    2 View Details [31..151] PSI-BLAST 201.502279 Allosteric threonine deaminase N-terminal domain; Allosteric threonine deaminase C-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • threonine synthase activity
    		•  3.59927532963055 bayes_pls_golite062009
  • cysteine synthase activity
    		•  2.82422444336531 bayes_pls_golite062009
  • catalytic activity
    		•  2.38994231321972 bayes_pls_golite062009
  • lyase activity
    		•  1.87743897464083 bayes_pls_golite062009
  • tryptophan synthase activity
    		•  1.15770474211356 bayes_pls_golite062009
  • carbon-oxygen lyase activity
    		•  0.923824749425553 bayes_pls_golite062009
  • ammonia-lyase activity
    		•  0.476674617721478 bayes_pls_golite062009
  • L-threonine ammonia-lyase activity
    		•  0.37325071016009 bayes_pls_golite062009
  • carbon-nitrogen lyase activity
    		•  0.249761226675912 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.93

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle