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Protein Overview: TYW1

General Information:
Name(s) found: TYW1 / YPL207W [SGD]
Description(s) found:
Found 27 descriptions.
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  • Protein required for the synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 810 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum [IDALink to PubMed article]
    Biological Process: biological_process [ND]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDGFRVAGAL VVGALTAAYL YFGGRFSIAL VIIVGYGIYC NEASGGSQDS QEKLDLNKQQ  60
   61 KKPCCSDKKI ADGGKKTGGC CSDKKNGGGK GGGCCSSKGG KKGGCCSSKG GKKGGCCSSK 120
  121 KNIGDNENTA TEVEKAVNYP VTVDFTEVFR KPTKKRSSTP KVFSKNSSSN SRVGKKLSVS 180
  181 KKIGPDGLIK SALTISNETL LSSQIYVLYS SLQGAASKAA KSVYDKLKEL DELTNEPKLL 240
  241 NLDDLSDFDD YFINVPVENA LYVLVLPSYD IDCPLDYFLQ TLEENANDFR VDSFPLRKLV 300
  301 GYTVLGLGDS ESWPEKFCYQ AKRADHWISR LGGRRIFPLG KVCMKTGGSA KIDEWTSLLA 360
  361 ETLKDDEPII YEYDENADSE EDEEEGNGSD ELGDVEDIGG KGSNGKFSGA DEIKQMVAKD 420
  421 SPTYKNLTKQ GYKVIGSHSG VKICRWTKNE LRGKGSCYKK SLFNIASSRC MELTPSLACS 480
  481 SKCVFCWRHG TNPVSKNWRW EVDEPEYILE NALKGHYSMI KQMRGVPGVI AERFAKAFEV 540
  541 RHCALSLVGE PILYPHINKF IQLLHQKGIT SFLVCNAQHP EALRNIVKVT QLYVSIDAPT 600
  601 KTELKKVDRP LYKDFWERMV ECLEILKTVQ NHQRTVFRLT LVKGFNMGDV SAYADLVQRG 660
  661 LPGFIEVKGA TFSGSSDGNG NPLTMQNIPF YEECVKFVKA FTTELQRRGL HYDLAAEHAH 720
  721 SNCLLIADTK FKINGEWHTH IDFDKFFVLL NSGKDFTYMD YLEKTPEWAL FGNGGFAPGN 780
  781 TRVYRKDKKK QNKENQETTT RETPLPPIPA

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) CSR1 TYW1
    View Details Gavin AC, et al. (2002) ACT1 ENO2 FPR4 NAN1 POL5 PWP1 SMC1 TYW1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data TYW1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..123] deduced N/A No confident structure predictions are available.
    2 View Details [124..173] PSI-BLAST 12.522879 Nitric oxide (NO) synthase oxygenase domain
    3 View Details [174..388] PSI-BLAST 67.39794 NADPH-cytochrome p450 reductase; NADPH-cytochrome p450 reductase, N-terminal domain
    4 View Details [389..445] PSI-BLAST 67.39794 NADPH-cytochrome p450 reductase; NADPH-cytochrome p450 reductase, N-terminal domain
    5 View Details [446..728] MSA 226.736997 View MSA. No confident structure predictions are available.
    6 View Details [729..810] MSA 2.247995 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • transcription regulator activity
    		•  0.62629924591908 bayes_pls_golite062009
  • binding
    		•  0.523120840489436 bayes_pls_golite062009
  • catalytic activity
    		•  0.275631658558537 bayes_pls_golite062009
    4
    Term Confidence Notes
  • catalytic activity
    		•  1.48331922124015 bayes_pls_golite062009
  • transferase activity
    		•  0.685192555939835 bayes_pls_golite062009
  • binding
    		•  0.60397276396442 bayes_pls_golite062009
  • protein binding
    		•  0.124485878765261 bayes_pls_golite062009
    5 No functions predicted.
    6 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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