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View Structure Prediction Details

Protein: KAP123
Organism: Saccharomyces cerevisiae
Length: 1113 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for KAP123.

Description E-value Query
Range		 Subject
Range
IMB4_YEAST - Importin subunit beta-4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=KAP123 PE=1 SV=1
gi|190405672 - gi|190405672|gb|EDV08939.1| karyopherin beta 4 [Saccharomyces cerevisiae RM11-1a]
gi|207345876 - gi|207345876|gb|EDZ72556.1| YER110Cp-like protein [Saccharomyces cerevisiae AWRI1631]
KAP123 - Karyopherin beta, mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and...
 0.0 [1..1113] [1..1113]
gi|12057236 - gi|12057236|gb|AAG45965.2| Ran binding protein 5 [Mus musculus]
 0.0 [3..1097] [8..1099]
RANBP6 - RAN binding protein 6
 0.0 [7..1096] [17..1103]
Karybeta3-PA, FB... - The gene Karyopherin Ã?ŽÃ?² 3 is referred to in FlyBase by the symbol Dmel\KaryÃ?ŽÃ?²3 (...
 0.0 [1..1111] [1..1102]
gi|15241189, gi|... - gi|15293299|gb|AAK93760.1| unknown protein [Arabidopsis thaliana], gi|15241189|ref|NP_197483.1| emb2...
 0.0 [2..1097] [20..1116]
kap123 - karyopherin Kap123
IMB4_SCHPO - Probable importin subunit beta-4 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=kap123 PE...
 0.0 [1..1112] [1..1066]
imb-3 - importin beta, nuclear transport factor status:Confirmed UniProt:Q9N5V3 protein_id:AAF39782.2
 0.0 [1..1096] [1..1090]

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Predicted Domain #1
Region A:
Residues: [1-238] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDQQFLSQLE QTLHAITSGV GLKEATKTLQ TQFYTQPTTL PALIHILQNG SDDSLKQLAG  60
   61 VEARKLVSKH WNAIDESTRA SIKTSLLQTA FSEPKENVRH SNARVIASIG TEELDGNKWP 120
  121 DLVPNLIQTA SGEDVQTRQT AIFILFSLLE DFTSSLSGHI DDFLALFSQT INDPSSLEIR 180
  181 SLSAQALNHV SALIEEQETI NPVQAQKFAA SIPSVVNVLD AVIKADDTMN AKLIFNCL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 99.228787
Match: 1qgkA_
Description: Importin beta
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein transporter activity 4.58709163830613 bayes_pls_golite062009
protein transmembrane transporter activity 2.74547353635661 bayes_pls_golite062009
binding 2.61658111885029 bayes_pls_golite062009
transporter activity 2.48700774379895 bayes_pls_golite062009
substrate-specific transporter activity 2.26725422172281 bayes_pls_golite062009
protein binding 2.13529412360404 bayes_pls_golite062009
nuclear localization sequence binding 1.91487015967262 bayes_pls_golite062009
nuclear export signal receptor activity 1.29390474721722 bayes_pls_golite062009
transmembrane transporter activity 1.28481004323799 bayes_pls_golite062009
RNA binding 1.20550543134698 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 1.09652988954158 bayes_pls_golite062009
signal sequence binding 0.57106697498903 bayes_pls_golite062009
structural molecule activity 0.449804281824548 bayes_pls_golite062009
active transmembrane transporter activity 0.252495966234234 bayes_pls_golite062009
ion transmembrane transporter activity 0.248585912061178 bayes_pls_golite062009
primary active transmembrane transporter activity 0.226380819487924 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 0.217517113570989 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 0.178770060806735 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 0.175241020572885 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 0.174922130116569 bayes_pls_golite062009
nucleic acid binding 0.169755106399802 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.100181463251306 bayes_pls_golite062009
pyrophosphatase activity 0.0635404099346928 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.0548082069333885 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.052195223119721 bayes_pls_golite062009
cation transmembrane transporter activity 0.0405268469927988 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [239-428] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NDFLLLDSQL TGNFIVDLIK LSLQIAVNSE IDEDVRVFAL QFIISSLSYR KSKVSQSKLG  60
   61 PEITVAALKV ACEEIDVDDE LNNEDETGEN EENTPSSSAI RLLAFASSEL PPSQVASVIV 120
  121 EHIPAMLQSA NVFERRAILL AISVAVTGSP DYILSQFDKI IPATINGLKD TEPIVKLAAL 180
  181 KCIHQLTTDL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 99.228787
Match: 1qgkA_
Description: Importin beta
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [429-523] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QDEVAKFHEE YLPLIIDIID SAKNIVIYNY ATVALDGLLE FIAYDAIAKY LDPLMNKLFY  60
   61 MLESNESSKL RCAVVSAIGS AAFAAGSAFI PYFKT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 99.228787
Match: 1qgkA_
Description: Importin beta
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [524-749] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SVHYLEKFIQ NCSQIEGMSE DDIELRANTF ENISTMARAV RSDAFAEFAE PLVNSAYEAI  60
   61 KTDSARLRES GYAFIANLAK VYGENFAPFL KTILPEIFKT LELDEYQFNF DGDAEDLAAF 120
  121 ADSANEEELQ NKFTVNTGIS YEKEVASAAL SELALGTKEH FLPYVEQSLK VLNEQVDESY 180
  181 GLRETALNTI WNVVKSVLLA SKVEPESYPK GIPASSYVNA DVLAVI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 99.228787
Match: 1qgkA_
Description: Importin beta
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [750-898] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QAARETSMGN LSDEFETSMV ITVMEDFANM IKQFGAIIIM DNGDSSMLEA LCMQVLSVLK  60
   61 GTHTCQTIDI EEDVPRDEEL DASETEATLQ DVALEVLVSL SQALAGDFAK VFDNFRPVVF 120
  121 GLFQSKSKNK RSSAVGAASE LALGMKEQN

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 14.16
Match: 1gw5B
Description: Adaptin beta subunit N-terminal fragment
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [899-1113] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PFVHEMLEAL VIRLTSDKSL EVRGNAAYGV GLLCEYASMD ISAVYEPVLK ALYELLSAAD  60
   61 QKALAAEDDE ATREIIDRAY ANASGCVARM ALKNSALVPL EQTVPALLAH LPLNTGFEEY 120
  121 NPIFELIMKL YQENSPVITN ETPRIIEIFS AVFTKENDRI KLEKESTLGR EENMERLKQF 180
  181 QTEEMKHKVI ELLKYLNTTY NGIVAQNPVL AAVIA

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 14.16
Match: 1gw5B
Description: Adaptin beta subunit N-terminal fragment
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle