Protein Overview: YTM1

General Information:
Name(s) found:	YTM1 / YOR272W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6324846\|ref\|NP_014915.1\| Constituent of 66S pre-ribosomal particles, required for maturation of the large ribosomal subunit; Ytm1p [Saccharomyces cerevisiae] [NCBI NR] gi\|2494905\|sp\|Q12024.1\|YTM1_YEAST RecName: Full=Ribosome biogenesis protein YTM1; AltName: Full=Microtubule-associated protein YTM1 [NCBI NR] pir\|\|S67174 hypothetical protein YOR272w - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|1928989\|gb\|AAB51396.1\| microtubule-associated protein [Saccharomyces cerevisiae] [NCBI NR] gi\|1420610\|emb\|CAA99497.1\| YTM1 [Saccharomyces cerevisiae] [NCBI NR] gi\|1279699\|emb\|CAA61778.1\| hypothetical protein [Saccharomyces cerevisiae] [NCBI NR] Ribosome biogenesis protein YTM1 OS=Saccharomyces cerevisiae GN=YTM1 PE=1 SV=1 [Swiss-Prot] YTM1 Microtubule-interacting protein [mips] Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Erb1p that is required for maturation of the large ribosomal subunit; has seven C-terminal WD repeats [SGD] (Q12024) Microtubule-associated protein YTM1 [4932.FASTACCERV.txt] Chr XV from 832810-834192 [hmr_yeast5_DM3-1_pombe.fasta] Chr XV from 832809-834191 [yeastorf3.fasta] YTM1, Chr XV from 832809-834191 [yeast_orfs2] YTM1 SGDID:S0005798, Chr XV from 832810-834192, Verified ORF [yeastflysequest.fasta] Ytm1p [Saccharomyces cerevisiae]gi\|1279699\|emb\|CAA61778.1\| hypothetical protein [Saccharomyces cerevisiae]gi\|1420610\|emb\|CAA99497.1\| YTM1 [Saccharomyces cerevisiae]gi\|2132107\|pir\|\|S67174 hypothetical protein YOR272w - yeast (Saccharomyces cerevisiae)g [nrdb_11152004_Chlamydomonas] YTM1 SGDID:S000005798, Chr XV from 832810-834192, Verified ORF, "Constituent of 66S pre-ribosomal particles, required for maturation of the large ribosomal subunit" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] YTM1 SGDID:S000005798, Chr XV from 832812-834194, Verified ORF, "Constituent of 66S pre-ribosomal particles, required for maturation of the large ribosomal subunit" [yeast-contam.fasta] YTM1 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Constituent of 66S pre-ribosomal particles, required for maturation of the large ribosomal subunit; Ytm1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Microtubule-associated protein YTM1 [nr-271106-contam.fasta] microtubule-associated protein [Saccharomyces cerevisiae] [nr-271106-contam.fasta] hypothetical protein [Saccharomyces cerevisiae] [nr-271106-contam.fasta] YTM1 SGDID:S000005798, Chr XV from 832812-834194, Verified ORF, "Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Erb1p that is required for maturation of the large ribosomal subunit; has seven C-terminal WD repeats" [SGD_S-cerevisiae_na_01-05-2010_reversed.fasta] [chemostatdb.fasta] Ribosome biogenesis protein YTM1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YTM1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] YTM1 SGDID:S000005798, Chr XV from 832813-834195, Genome Release 64-1-1, Verified ORF, "Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Erb1p that is required for maturation of the large ribosomal subunit; has seven C-terminal WD repeats" [yeast-030211-contam.fasta] YTM1 SGDID:S000005798, Chr XV from 832813-834195, Genome Release 64-2-1, Verified ORF, "Constituent of 66S pre-ribosomal particles; forms a complex with Nop7p and Erb1p that is required for maturation of the large ribosomal subunit; has seven C-terminal WD repeats" [20141208_orf_trans.fasta] YOR272W SGDID:S000005798, Chr XV from 832813-834195, Genome Release 64-1-1, Verified ORF, "Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Erb1p that is required for maturation of the large ribosomal subunit; has seven C-terminal WD repeats" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	460 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA] nucleolus [IDA]
Biological Process:	ribosomal large subunit biogenesis [IMP][IPI ] ribosome biogenesis [RCA]
Molecular Function:	molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTEDKSQVKI RFFTREKDEL LHVQDTPMYA PISLKRYGLS EIVNHLLGSE KPVPFDFLIE  60
   61 GELLRTSLHD YLTKKGLSSE ASLNVEYTRA ILPPSYLNSF SNEDWVSSLD VGDGSKHIIS 120
  121 GSYDGIVRTW DLSGNVQKQY SGHSGPIRAV KYISNTRLVS AGNDRTLRLW KTKNDDLKLT 180
  181 SQQQAQEDDD DEVNIEDGKT LAILEGHKAP VVSIDVSDNS RILSASYDNS IGFWSTIYKE 240
  241 MTVVDPLEDI NNPNNKISTA ARKRRKLTMK DGTIRRRAPL SLLESHTAPV EQVIFDSTDN 300
  301 TVGYSVSQDH TIKTWDLVTA RCIDTRTTSY SLLSIAQLST LNLLACGSSA RHITLHDPRV 360
  361 GASSKVTQQQ LIGHKNFVSS LDTCPENEYI LCSGSHDGTV KVWDVRSTSP MYTITREDKS 420
  421 VQKGVNDKVF AVKWAEKVGI ISAGQDKKIQ INKGDNIFKN

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		BRX1 CIC1 DBP10 DBP9 DRS1 EBP2 ERB1 HAS1 LOC1 MAK21 MAK5 MRT4 NIP7 NOC2 NOC3 NOG1 NOP1 NOP12 NOP15 NOP2 NOP4 NOP7 NSA1 NSA2 NUG1 PUF6 RIX1 RIX7 RLP7 RPF1 RPL25 RRP1 RRP12 SDA1 SPB1 SPB4 TIF6 URB1 YTM1
View Details	(MIPS) Mewes HW, et al. (2004)		ASE1 ATG4 ATG8 BIK1 BIM1 CBF5 CIN2 CIN4 MHP1 RBL2 SPC98 STU1 STU2 YTM1
View Details	Krogan NJ, et al. (2006)		MSS1 NOP7 NTE1 PDS5 SOP4 STP3 YGR067C YTM1
View Details	Gavin AC, et al. (2006)		BRX1 CIC1 DBP9 MAK21 MAK5 NOC2 NOP4 RLP7 RSA3 SPB4 YTM1
View Details	Gavin AC, et al. (2002)		AAR2 ARX1 BEM2 BMS1 BRX1 BUD20 CBF5 CIC1 CLU1 CYR1 CYS4 DBP10 DBP9 DCP2 DRS1 EBP2 ERB1 FPR4 FUN12 GAR1 GCN1 HAS1 HDA1 HER1 HIS3 INP2 IPI1 IPI3 KRE33 KRR1 LHP1 LOC1 LSG1 MAK21 MAK5 MDN1 MIS1 MRP7 MRT4 NAP1 NHP2 NIP1 NIP7 NMD3 NOC2 NOC3 NOG1 NOG2 NOP1 NOP12 NOP15 NOP16 NOP2 NOP4 NOP56 NOP6 NOP7 NSA1 NSA2 NUG1 POL2 PRP4 PRT1 PUF6 REI1 RIX1 RIX7 RLP24 RLP7 RPA135 RPA190 RPF1 RPF2 RPG1 RPP2B RPT6 RRP1 RRP12 RSA3 RSA4 RTR1 SDA1 SEC7 SKI2 SMB1 SNU114 SNU13 SNU66 SPB1 SPB4 SRO9 SSF1 TIF4631 TIF4632 TIF6 TUB3 URB1 UTP10 UTP20 UTP21 UTP22 YGL036W YMR310C YTM1
View Details	Ho Y, et al. (2002)		AAC3 ACO1 ARP4 ASA1 ATG17 ATG29 ATP3 BFA1 CBF5 CBP2 CCM1 CCT6 CDC14 CDC15 CDC33 CFT1 CIC1 CIS1 CKA2 CKB2 CLU1 CYS4 DBP10 DBP7 DNL4 DUG2 EBP2 EGD2 ELA1 ENP2 ERB1 FAA4 FIN1 FIP1 FOL2 FPR3 FPR4 GBP2 GDE1 GLC7 GLC8 GND1 GPH1 GRH1 GUS1 HAP2 HAP5 HAS1 HER1 HMO1 HTA1 HTB2 HXT7 IMD1 IMD3 IMD4 IPP1 ISA1 KEL1 KGD1 KRE33 KRI1 LOC1 MAK16 MAM33 MET6 MGM101 MHP1 MRT4 MSS116 MTQ1 MUB1 NAP1 NMD5 NOC2 NOC3 NOG1 NOP1 NOP12 NOP15 NOP16 NOP2 NOP6 NOP7 NPL3 NSA1 NSA2 NUG1 NUP53 PET127 POL5 PRP43 PSE1 PUF6 PWP1 REG1 RHR2 RLI1 RNR1 RNR2 RPF1 RPF2 RRP1 RRP12 RRP15 RRP17 RRP5 RRT6 SAH1 SAP190 SCD5 SCS2 SDS22 SEC53 SEN1 SPB1 SPB4 SPE3 SRP1 SRP54 SSD1 SSK2 SSQ1 SUI2 SUI3 TEM1 TIF1, TIF2 TIF4631 TIF6 TIS11 TMA108 TRA1 TSR1 UBR2 URB1 URB2 UTP10 UTP20 VPS35 YBR242W YER077C YPD1 YPP1 YRA1 YRA2 YTM1

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	MLP2	#12 Mitotic Prep1-TiO2 Flowthrough	Keck JM, et al. (2011)
View Run	MLP2	#10 Mitotic Prep1-TiO2 Phosphopeptide enrichment	Keck JM, et al. (2011)
View Run	MLP2	#11 Mitotic Prep1-TiO2 enriched, new search criteria	Keck JM, et al. (2011)
View Run	MLP2	#28 Asynchronous Prep5-TiO2 Phosphopeptide Enrichment	Keck JM, et al. (2011)
View Run	MLP2	#05 Alpha Factor Prep2-TiO2 Flowthrough	Keck JM, et al. (2011)
View Run	MLP2	#07 Alpha Factor Prep3-TiO2 Flowthrough	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	SNF1	YTM1	1	Unpublished Fields Lab Data
View Screen	CDC23	YTM1	1	Unpublished Fields Lab Data

Microscopy / Localization Data

New Feature: Upload Your Own Microscopy Data

	PROTEIN(S)	PUBLICATION
View Data	YTM1	Huh WK, et al. (2003)
View Data	YTM1 and NOP56	Huh WK, et al. (2003)

Protein Structure Data

[What does the above image mean?]
[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..404]	PSI-BLAST	93.06601	beta1-subunit of the signal-transducing G protein heterotrimer
2	View Details	[405..460]	PSI-BLAST	150.0	Tup1, C-terminal domain
3	View Details	[397..460]	PSI-BLAST	28.522879	No description for 2pm6B was found.

Functions predicted (by domain):

Gene Ontology predictions

No functions predicted.

Term	Confidence	Notes
snoRNA binding	3.51833501249106	bayes_pls_golite062009
	3.41022148055944	bayes_pls_golite062009
RNA binding	3.0829625416797	bayes_pls_golite062009
binding	2.42570478946173	bayes_pls_golite062009
histone methyltransferase activity (H3-K4 specific)	2.299832037975	bayes_pls_golite062009
cytoskeletal protein binding	2.20122168933317	bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity	1.95039718468175	bayes_pls_golite062009
actin binding	1.40054662654509	bayes_pls_golite062009
transcription regulator activity	1.25687092973217	bayes_pls_golite062009
protein binding	1.21879977456466	bayes_pls_golite062009
nucleic acid binding	1.20712373307552	bayes_pls_golite062009
structural molecule activity	1.20572493724069	bayes_pls_golite062009
tubulin binding	1.10875870970504	bayes_pls_golite062009
microtubule binding	1.03769395387791	bayes_pls_golite062009
DNA binding	0.711274653406079	bayes_pls_golite062009
ligase activity	0.280267687917718	bayes_pls_golite062009
transcription factor activity	0.243992994917491	bayes_pls_golite062009
dynein binding	0.180120691665679	bayes_pls_golite062009
histone binding	0.166694897714113	bayes_pls_golite062009
chromatin binding	0.145491963066342	bayes_pls_golite062009
mRNA binding	0.0519838181830878	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.97

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2