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Protein Overview: NTE1

General Information:
Name(s) found: NTE1 / YML059C [SGD]
Description(s) found:
Found 28 descriptions.
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  • Serine esterase, homolog of human neuropathy target esterase (NTE); Nte1p-mediated phosphatidylcholine turnover influences transcription factor Opi1p localization, affecting transcriptional regulation of phospholipid biosynthesis genes [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1679 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum [IDALink to PubMed articleLink to PubMed article]
    Biological Process: sinus venosus formation [IDALink to PubMed article]
    phosphatidylcholine metabolic process [IMPLink to PubMed article]
    Molecular Function: lysophospholipase activity [IDALink to PubMed article]
    hydrolase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRSMNCTTNN TNNTGQNTKN SLGSSFNSSN YTSYRFQTCL TDQIISEAQT WSLSSLFNFS  60
   61 WVVSYFVMGA SRMIFRYGWY LATLSLLRIP KWIFFKLHHV QFTLSFWLIL FALAVIVFVT 120
  121 YTIMKERILS QYKRLTPEFL PLENTGKSGS SANINAASTQ SANAPPAIGS STTGASSIID 180
  181 SKKHSLKDGN ENETFLSSYL DQFLSAIKIF GYLEKPVFHD LTKNMKTQKM DEGEILLLDS 240
  241 TIGFAIVVEG TLQLYHEVDH SDKDHGDETD HSDTDGLDDQ DRDEEDEEED DDIDNYDTKS 300
  301 CSSNLIDEED ESVGYIHLKN GLGNFQLLNT VKPGNPLTSL VSILNLFTHS MSSYGNSNFP 360
  361 SELSSPIDTT VSVNNMFCSS EQNFSNTDSM TNSTNSFPTF PSSMPKLVAR AATDCTIGII 420
  421 PPQSFAKLTA KYPRSASHII QMVLTKLYHV TFQTAHDYLG LTKEIMDIEV LLNKSIVYEL 480
  481 PYYLKEAVIR KFKTVDKSSG SADLEPKPKN SNASSKLKKP PKAKPSDGII QSLKIANANA 540
  541 NTSSNSLSLK PEFTHHPSSR HVVLGSRDQF NPGDLLSNVP LSRTMDILSP NPIHNNNRNK 600
  601 SNGINTSTSN QHKRSSRSSS NNASVHSKKF SSLSPELRNA QLSTSPLSLD NTSVHDHIHP 660
  661 SPVHLKGRVS PRPNLLPTTS FSAAQEETED SALRMALVEA MLTYLGVNKS NMSVSSSSIA 720
  721 NMSSLNSPQL NEMYSRRPSN ASFLMSPHCT PSDISVASSF ASPQTQPTML RILPKEYTIS 780
  781 NKRHNKSKSQ DKKKPRAYKE ELTPNLDFED VKKDFAQGIQ LKFFKKGTTI VEQNARGKGL 840
  841 FYIISGKVNV TTNSSSSVVS SMSKPEQVSA QSSHKGENPH HTQHLLYSVG SGGIVGYLSS 900
  901 LIGYKSFVNI VAKSDVYVGF LSSATLERLF DKYFLIYLRI SDSLTKLLSS RLLKLDHALE 960
  961 WVHLRASETL FSQGDSANGI YVVLNGRLRQ LQQQSLSNSN TSSEEVETQN IILGELAQGE1020
 1021 SFGEVEVLTA MNRYSTIVAV RDSELARIPR TLFELLALEH PSIMIRVSRL VAKKIVGDRT1080
 1081 VPALTGDPLS IKENDFTSLI PPTKASYSSS LSHKPQNITS GTITFRTITI LPITSGLPVE1140
 1141 AFAMKLVQAF KQVGRTTIGL NQRTTLTHLG RHAFDRLSKL KQSGYFAELE EMYQTVVYIS1200
 1201 DTPVKSNWTR TCIAQGDCIL LLADARSPSA EIGEYEKLLL NSKTTARTEL ILLHPERYVE1260
 1261 PGLTHKWLRY RPWVHSHHHI QFSLTGTTLM NEGKMHVLNN GALALMDKLI QTEFSRKTQQ1320
 1321 NISKLLPDSI KNTVENFSSR FMKSKRQYYT PVHRHKNDFL RLARILSGQA IGLVLGGGGA1380
 1381 RGISHLGVIQ AIEEQGIPVD VIGGTSIGSF VGGLYAKDYD LVPIYGRVKK FAGRISSIWR1440
 1441 MLTDLTWPVT SYTTGHEFNR GIWKTFGDTR IEDFWIQYYC NSTNITDSVQ EIHSFGYAWR1500
 1501 YIRASMSLAG LLPPLEENGS MLLDGGYVDN LPVTEMRARG CQTIFAVDVG SADDRTPMEY1560
 1561 GDSLNGFWII FNRWNPFSSH PNIPNMAEIQ VRLGYVASVN ALEKAKNTPG VVYVRPPIEE1620
 1621 YATLDFSKFE EIYHVGVDYG RIFLQGLIDD DKMPYIPGSQ ETTLNSQVPE FLLHRRNSI

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) MSS1 NOP7 NTE1 PDS5 SOP4 STP3 YGR067C YTM1
    View Details Gavin AC, et al. (2002) NTE1 PDB1 PSE1
    View Details Qiu et al. (2008) BST1 NTE1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #19 Asynchronous Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #02 Alpha Factor Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)
    View Run MLP2 #19b Asynchronous Prep1-new search criteria Keck JM, et al. (2011)
    View Run MLP2 #19a Asynchronous Prep1-new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data NTE1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..299] deduced N/A No confident structure predictions are available.
    2 View Details [300..381] MSA 1.002995 View MSA. No confident structure predictions are available.
    3 View Details [382..651] deduced N/A No confident structure predictions are available.
    4 View Details [652..1071] PSI-BLAST 138.616428 No description for 1apk__ was found.
    5 View Details [1072..1163] PSI-BLAST 47.0 No description for 2gapA_ was found.
    6 View Details [1164..1283] MSA 1.170988 View MSA. Confident ab initio structure predictions are available.
    7 View Details [1284..1349] deduced N/A No confident structure predictions are available.
    8 View Details [1350..1679] MSA 52.142993 View MSA. No confident structure predictions are available.
    9 View Details [1552..1679] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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