Protein Overview: ADH1

General Information:
Name(s) found:	ADH1 / YOL086C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6324486\|ref\|NP_014555.1\| Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway; Adh1p [Saccharomyces cerevisiae] [NCBI NR] gi\|600472\|emb\|CAA58193.1\| orf 00947 [Saccharomyces cerevisiae] [NCBI NR] pir\|\|DEBYA alcohol dehydrogenase (EC 1.1.1.1) 1 - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|1419926\|emb\|CAA99098.1\| ADH1 [Saccharomyces cerevisiae] [NCBI NR] ADH1 Alcohol dehydrogenase I [mips] Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway [SGD] Chr XV from 160593-159547, reverse complement [hmr_yeast5_DM3-1_pombe.fasta] Chr XV from 159547-160593, reverse complement [yeastorf3.fasta] ADH1, Chr XV from 159547-160593, reverse complement [yeast_orfs2] ADH1 SGDID:S0005446, Chr XV from 160593-159547, reverse complement, Verified ORF [yeastflysequest.fasta] Adh1p [Saccharomyces cerevisiae]gi\|600472\|emb\|CAA58193.1\| orf 00947 [Saccharomyces cerevisiae]gi\|1419926\|emb\|CAA99098.1\| ADH1 [Saccharomyces cerevisiae]gi\|2144315\|pir\|\|DEBYA alcohol dehydrogenase (EC 1.1.1.1) 1 - yeast (Saccharomyces cerevisiae) [nrdb_11152004_Chlamydomonas] ADH1 SGDID:S000005446, Chr XV from 160593-159547, reverse complement, Verified ORF, "Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pat [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] ADH1 SGDID:S000005446, Chr XV from 160594-159548, reverse complement, Verified ORF, "Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pat [yeast-contam.fasta] Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway; Adh1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] orf 00947 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] ADH1 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] ADH1 SGDID:S000005446, Chr XV from 160594-159548, reverse complement, Verified ORF, "Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway" [yeast-bovrabprots.fasta] [chemostatdb.fasta] Alcohol dehydrogenase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ADH1 PE=1 SV=5 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] ADH1 SGDID:S000005446, Chr XV from 160594-159548, Genome Release 64-1-1, reverse complement, Verified ORF, "Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway" [yeast-030211-contam.fasta] ADH1 SGDID:S000005446, Chr XV from 160594-159548, Genome Release 64-2-1, reverse complement, Verified ORF, "Alcohol dehydrogenase; fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway; ADH1 has a paralog, ADH5, that arose from the whole genome duplication" [20141208_orf_trans.fasta] YOL086C SGDID:S000005446, Chr XV from 160594-159548, Genome Release 64-1-1, reverse complement, Verified ORF, "Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	348 amino acids
Gene Ontology:
Cellular Component:	cytosol [TAS]
Biological Process:	fermentation [IMP] NADH oxidation [IDA][IMP] ethanol biosynthetic process involved in glucose fermentation to ethanol [IMP]
Molecular Function:	alcohol dehydrogenase (NAD) activity [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSIPETQKGV IFYESHGKLE YKDIPVPKPK ANELLINVKY SGVCHTDLHA WHGDWPLPVK  60
   61 LPLVGGHEGA GVVVGMGENV KGWKIGDYAG IKWLNGSCMA CEYCELGNES NCPHADLSGY 120
  121 THDGSFQQYA TADAVQAAHI PQGTDLAQVA PILCAGITVY KALKSANLMA GHWVAISGAA 180
  181 GGLGSLAVQY AKAMGYRVLG IDGGEGKEEL FRSIGGEVFI DFTKEKDIVG AVLKATDGGA 240
  241 HGVINVSVSE AAIEASTRYV RANGTTVLVG MPAGAKCCSD VFNQVVKSIS IVGSYVGNRA 300
  301 DTREALDFFA RGLVKSPIKV VGLSTLPEIY EKMEKGQIVG RYVVDTSK

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		ADH1 ADH2 ADH3 BMH2 EFT2, EFT1 ENO1 FBA1 GPM1 HSC82 HYP2 IPP1 PDC1 PGI1 RPL40B, RPL40A TDH1 TDH2 TIF1, TIF2 TKL1 TPI1 TRX1 TRX2 YEF3
View Details	Hazbun TR, et al. (2003)		ADH1 KAP123 MIA40 TOM40
View Details	Gavin AC, et al. (2006)		ADH1 PRC1
View Details	Gavin AC, et al. (2002)		ACT1 ADA2 ADH1 AOS1 ARP4 ARP8 ARX1 ATG18 ATG2 BEM2 BGL2 CBF5 CCT4 CDC14 CLU1 COG3 CSE1 CSE2 DHH1 DIM1 DUG1 EAF1 EAF3 EAF5 ECM1 ECM16 ECM29 EMG1 ENO2 ENP1 EPL1 ESA1 ESC8 FAB1 FAR11 FAR3 FBA1 FET5 FKS1 FTH1 FUN19 GAL11 GCN1 GCN20 GCN5 GEA2 GFA1 GIN4 GPM1 HEM13 HFM1 HHF1, HHF2 HMO1 HRR25 HSC82 HSP42 IDH2 IES1 IES5 ILS1 IMP3 IMP4 INO80 IOC3 ISW1 ISW2 ITC1 KAP114 KAP123 KCC4 KRE33 KRR1 KTR3 LEU1 LTV1 LYS2 MED1 MED11 MED2 MED4 MED6 MED7 MED8 MES1 MIR1 MLC1 MLC2 MLP1 MNN4 MOT1 MPP10 MRPL6 MYO1 MYO2 MYO4 NET1 NGG1 NHP10 NIP1 NOB1 NOC4 NOP1 NOP14 NPL6 NUT1 NUT2 PBP2 PDC1 PEP4 PFK2 PGD1 PGI1 PGK1 PNO1 PSE1 PSK1 PTC1 PUF6 RAD1 RAD10 RAD16 RCL1 RGR1 RIM1 RIO2 ROM2 ROX3 RPB2 RPC40 RPG1 RPN3 RPN9 RPO21 RPT5 RRP12 RSC2 RSC4 RSC58 RSC6 RSC8 RVB2 SAM1 SEC1 SEC7 SGF29 SGF73 SHE2 SHE3 SIN3 SIN4 SIR2 SIR4 SLC1 SLX9 SNF2 SNF5 SNT2 SOF1 SPT15 SPT20 SPT7 SPT8 SRB2 SRB4 SRB5 SRB6 SRB7 SRB8 SRP1 SRV2 SSE2 SSN2 SSN3 SSN8 SWI3 SXM1 TAF1 TAF10 TAF11 TAF12 TAF13 TAF14 TAF2 TAF3 TAF4 TAF5 TAF6 TAF7 TAF8 TAF9 TBF1 TDH3 TEF4 TIF1, TIF2 TPI1 TRA1 TSR1 UBA2 UBP14 UTP15 UTP20 UTP22 UTP6 UTP7 VAS1 VMA4 VPS1 WRS1 YAF9 YAP1 YEF3 YGR054W YHR020W YIL077C YMR315W YRA1
View Details	Qiu et al. (2008)		ADH1 ADH2 ADH3 GPD1

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	PSF2	No Comments	Hazbun TR, et al. (2003)
View Run	TOR1	No Comments	Reinke A, et al. (2004)
View Run	MIA40	No Comments	Hazbun TR, et al. (2003)
View Run	TIM50	No Comments	Hazbun TR, et al. (2003)
View Run	TOR1	No Comments	Reinke A, et al. (2004)
View Run	PGA1	No Comments	Hazbun TR, et al. (2003)
View Run	NOP9	No Comments	Hazbun TR, et al. (2003)
View Run	KAE1	No Comments	Hazbun TR, et al. (2003)
View Run	MIA40	No Comments	Hazbun TR, et al. (2003)
View Run	LST8	No Comments	Reinke A, et al. (2004)
View Run	TOR2	No Comments	Reinke A, et al. (2004)
View Run	CLB2	No Comments	McCusker D, et al (2007)
View Run	BIR1	No Comments	Widlund PO, et al. (2005)
View Run	DAD1	Dam1 complex purified from yeast with Dad1-TAP	Shimogawa MM, et al. (2006)
View Run	RPA135	his-HA tag on RPA135	Schneider, DA, et al. (2006)
View Run	RPA135	his-HA tag on RPA135	Schneider, DA, et al. (2006)
View Run	HIR2	No Comments	Green EM, et al (2005)
View Run	DAD1	Dam1-765 complex purified from yeast with Dad1-TAP	Shimogawa MM, et al. (2006)
View Run	ASF1	3912: TAP-tagged, strain background includes hpc2(delta)	Green EM, et al (2005)
View Run	RLF2	cac1: TAP-tagged	Green EM, et al (2005)
View Run	DAD1	Dam1-765 complex purified from yeast with Dad1-TAP	Shimogawa MM, et al. (2006)
View Run	DAD1	Dam1 complex purified from yeast with Dad1-TAP	Shimogawa MM, et al. (2006)
View Run	RPA135	No Comments	Schneider, DA, et al. (2006)
View Run	RLF2	identification data - first search in cascade	Green EM, et al (2005)
View Run	VAM3	hx23: mixture in detergent (control) Investigating Vam3p, Nyv1p and their partners in trans-SNARE complex	Hao Xu, et al. (2010)
View Run	MLP2	#25 Asynchronous Prep3-TiO2 Flowthrough	Keck JM, et al. (2011)
View Run	MLP2	#24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment	Keck JM, et al. (2011)
View Run	MLP2	#26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2	Keck JM, et al. (2011)
View Run	MLP2	#32 Asynchronous Prep-No Phosphopeptide enrichment	Keck JM, et al. (2011)
View Run	MLP2	#04 Alpha Factor Prep2	Keck JM, et al. (2011)
View Run	MLP2	#08 Alpha Factor Prep4-TiO2 Phosphopeptide enrichment	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	APC5	ADH1	1	Unpublished Fields Lab Data
View Screen	ADH2	ADH1	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..140]	PSI-BLAST	289.0	Alcohol dehydrogenase
2	View Details	[141..157] [296..348]	PSI-BLAST	289.0	Alcohol dehydrogenase
3	View Details	[158..295]	PSI-BLAST	289.0	Alcohol dehydrogenase

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.66

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2