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Protein Overview: TRX1

General Information:
Name(s) found: TRX1 / YLR043C [SGD]
Description(s) found:
Found 38 descriptions.
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  • Cytoplasmic thioredoxin isoenzyme of the thioredoxin system which protects cells against oxidative and reductive stress, forms LMA1 complex with Pbi2p, acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritance [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 103 amino acids

    Gene Ontology:
    Cellular Component: cytosol [IDALink to PubMed article]
    fungal-type vacuole [IPILink to PubMed article]
    Biological Process: vacuole inheritance [IMPLink to PubMed articleLink to PubMed article]
    response to oxidative stress [ISSLink to PubMed article]
    ER to Golgi vesicle-mediated transport [IDALink to PubMed article]
    retrograde vesicle-mediated transport, Golgi to ER [IDALink to PubMed article]
    DNA-dependent DNA replication [IMPLink to PubMed articleLink to PubMed article]
    vacuole fusion, non-autophagic [IDALink to PubMed article]
    sulfate assimilation [IGILink to PubMed article]
    Molecular Function: thiol-disulfide exchange intermediate activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVTQFKTASE FDSAIAQDKL VVVDFYATWC GPCKMIAPMI EKFSEQYPQA DFYKLDVDEL  60
   61 GDVAQKNEVS AMPTLLLFKN GKEVAKVVGA NPAAIKQAIA ANA

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ADH1 ECM10 IPP1 MLC1 TRX1 TRX2 TSA1
    View Details Hazbun TR, et al. (2003) AMN1 AXL2 IMH1 PEX19 PFK27 RAX2 RGT2 RIC1 RIX7 RPA190 SST2 TRX1 TRX2 YLR035C-A
    View Details Krogan NJ, et al. (2006) AIM22 DPH1 DPH2 EFT2, EFT1 HGH1 MNN1 PGI1 RRG10 TRX1 YMR315W
    View Details Qiu et al. (2008) GRX2 TRX1 TRX2 VMA9

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RIX7 No Comments Hazbun TR, et al. (2003)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data TRX1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..103] PSI-BLAST 226.67837 Thioredoxin


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle