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Protein Overview: DPH1

General Information:
Name(s) found: DPH1 / YIL103W [SGD]
Description(s) found:
Found 23 descriptions.
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  • Protein required, along with Dph2p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph2p and Kti11p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 425 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed articleLink to PubMed article]
    Biological Process: peptidyl-diphthamide biosynthetic process from peptidyl-histidine [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGSTESKKQ PRRRFIGRKS GNSNNDKLTT VAENGNEIIH KQKSRIALGR SVNHVPEDIL  60
   61 NDKELNEAIK LLPSNYNFEI HKTVWNIRKY NAKRIALQMP EGLLIYSLII SDILEQFCGV 120
  121 ETLVMGDVSY GACCIDDFTA RALDCDFIVH YAHSCLVPID VTKIKVLYVF VTINIQEDHI 180
  181 IKTLQKNFPK GSRIATFGTI QFNPAVHSVR DKLLNDEEHM LYIIPPQIKP LSRGEVLGCT 240
  241 SERLDKEQYD AMVFIGDGRF HLESAMIHNP EIPAFKYDPY NRKFTREGYD QKQLVEVRAE 300
  301 AIEVARKGKV FGLILGALGR QGNLNTVKNL EKNLIAAGKT VVKIILSEVF PQKLAMFDQI 360
  361 DVFVQVACPR LSIDWGYAFN KPLLTPYEAS VLLKKDVMFS EKYYPMDYYE AKGYGRGETP 420
  421 KHAIE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ATS1 DPH1 DPH2 EFT2, EFT1 KTI11
    View Details Krogan NJ, et al. (2006) AIM22 DPH1 DPH2 EFT2, EFT1 HGH1 MNN1 PGI1 RRG10 TRX1 YMR315W
    View Details Gavin AC, et al. (2006) DPH1 DPH2 EFT2, EFT1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen CIA1 DPH1 2 Hazbun TR, et al. (2003)
    View Screen IMP4 DPH1 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data DPH1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..162] deduced N/A No confident structure predictions are available.
    2 View Details [163..226]
    [282..425]    		 ORFEUS 7.04 50S subunit
    3 View Details [227..281] ORFEUS 7.04 50S subunit


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle