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Protein Overview: DPH2

General Information:
Name(s) found: DPH2 / YKL191W [SGD]
Description(s) found:
Found 30 descriptions.
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  • Protein required, along with Dph1p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph1p and Kti11p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 534 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: peptidyl-diphthamide biosynthetic process from peptidyl-histidine [IMPLink to PubMed articleLink to PubMed article]
    ribosome biogenesis [RCALink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEVAPALSTT QSDVAFQKVE THEIDRSSYL GPCYNSDELM QLISAYYNVE PLVGYLEQHP  60
   61 EYQNVTLQFP DDLIKDSSLI VRLLQSKFPH GKIKFWVLAD TAYSACCVDE VAAEHVHAEV 120
  121 VVHFGDACLN AIQNLPVVYS FGTPFLDLAL VVENFQRAFP DLSSKICLMA NAPFSKHLSQ 180
  181 LYNILKGDLH YTNIIYSQVN TSAVEEKFVT ILDTFHVPED VDQVGVFEKN SVLFGQHDKA 240
  241 DNISPEDYHL FHLTTPQDPR LLYLSTVFQS VHIFDPALPG MVTGPFPSLM RRYKYMHVAR 300
  301 TAGCIGILVN TLSLRNTRET INELVKLIKT REKKHYLFVV GKPNVAKLAN FEDIDIWCIL 360
  361 GCSQSGIIVD QFNEFYKPII TPYELNLALS EEVTWTGKWV VDFRDAIDEI EQNLGGQDTI 420
  421 SASTTSDEPE FDVVRGRYTS TSRPLRALTH LELEAADDDD SKQLTTRHTA SGAVIKGTVS 480
  481 TSASALQNRS WKGLGSDFDS TEVDNTGADI EEGISGVARG YGFDREDAMK KENK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ATS1 DPH1 DPH2 EFT2, EFT1 KTI11
    View Details Krogan NJ, et al. (2006) AIM22 DPH1 DPH2 EFT2, EFT1 HGH1 MNN1 PGI1 RRG10 TRX1 YMR315W
    View Details Gavin AC, et al. (2006) DPH1 DPH2 EFT2, EFT1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data DPH2 Huh WK, et al. (2003)

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..423] Pfam 13.39794 Putative diphthamide synthesis protein No confident structure predictions are available.
    2 View Details [424..534] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.88

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle