Protein Overview: TRX1

General Information:
Name(s) found:	TRX1 / YLR043C [SGD]
Description(s) found: SHOW ONLY BEST	pir\|\|TXBY2 thioredoxin II - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|6323072\|ref\|NP_013144.1\| Cytoplasmic thioredoxin isoenzyme of the thioredoxin system which protects cells against oxidative and reductive stress, forms LMA1 complex with Pbi2p, acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole i [NCBI NR] gi\|45270296\|gb\|AAS56529.1\| YLR043C [Saccharomyces cerevisiae] [NCBI NR] gi\|173048\|gb\|AAA35177.1\| thioredoxin 1 [NCBI NR] gi\|173028\|gb\|AAA35171.1\| thioredoxin II [Saccharomyces cerevisiae] [NCBI NR] gi\|152149105\|pdb\|2I9H\|A Chain A, Nmr Solution Structure Of The Reduced Form Of Thioredoxin 1 From Yeast (Trx1) [NCBI NR] gi\|1360373\|emb\|CAA97572.1\| TRX1 [Saccharomyces cerevisiae] [NCBI NR] gi\|135747\|sp\|P22217.3\|TRX1_YEAST RecName: Full=Thioredoxin-1; AltName: Full=Thioredoxin I; Short=TR-I; AltName: Full=Thioredoxin-2 [NCBI NR] Thioredoxin-1 OS=Saccharomyces cerevisiae GN=TRX1 PE=1 SV=3 [Swiss-Prot] TRX1 Thioredoxin I [mips] Cytoplasmic thioredoxin isoenzyme of the thioredoxin system which protects cells against oxidative and reductive stress, forms LMA1 complex with Pbi2p, acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritance [SGD] TRX1, Chr XII from 231703-232014, reverse complement [yeast_orfs2] Chr XII from 231703-232014, reverse complement [yeastorf3.fasta] Chr XII from 232014-231703, reverse complement [yeastorf5.fasta] TRX1 SGDID:S0004033, Chr XII from 232014-231703, reverse complement, Verified ORF [yeastflysequest.fasta] Trx1p [Saccharomyces cerevisiae]gi\|1360373\|emb\|CAA97572.1\| TRX1 [Saccharomyces cerevisiae]gi\|65806\|pir\|\|TXBY2 thioredoxin II - yeast (Saccharomyces cerevisiae)gi\|45270296\|gb\|AAS56529.1\| YLR043C [Saccharomyces cerevisiae]gi\|135747\|sp\|P22217\|TRX1_YEAST [nrdb_11152004_Chlamydomonas] TRX1 SGDID:S000004033, Chr XII from 232014-231703, reverse complement, Verified ORF, "Cytoplasmic thioredoxin isoenzyme of the thioredoxin system which protects cells against both oxidative and reductive stress, forms LMA1 complex with Pbi2p, acts as a co [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] TRX1 SGDID:S000004033, Chr XII from 232014-231703, reverse complement, Verified ORF, "Cytoplasmic thioredoxin isoenzyme of the thioredoxin system which protects cells against oxidative and reductive stress, forms LMA1 complex with Pbi2p, acts as a cofacto [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta] Cytoplasmic thioredoxin isoenzyme of the thioredoxin system which protects cells against both oxidative and reductive stress, forms LMA1 complex with Pbi2p, acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritance; Trx1p [Sacc [nr-271106-contam.fasta] YLR043C [Saccharomyces cerevisiae] [nr-271106-contam.fasta] TRX1 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] thioredoxin 1 [nr-271106-contam.fasta] thioredoxin II [nr-271106-contam.fasta] Thioredoxin I (TR-I) (Thioredoxin 2) [nr-271106-contam.fasta] TRX1 SGDID:S000004033, Chr XII from 232014-231703, reverse complement, Verified ORF, "Cytoplasmic thioredoxin isoenzyme of the thioredoxin system which protects cells against oxidative and reductive stress, forms LMA1 complex with Pbi2p, acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritance" [yeast-bovrabprots.fasta] TRX1 SGDID:S000004033, Chr XII from 232014-231703, reverse complement, Verified ORF, "Cytoplasmic thioredoxin isoenzyme of the thioredoxin system which protects cells against both oxidative and reductive stress, forms LMA1 complex with Pbi2p, acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritance" [yeast-contam_custom.fasta] [chemostatdb.fasta] Thioredoxin-1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TRX1 PE=1 SV=3 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] TRX1 SGDID:S000004033, Chr XII from 232013-231702, Genome Release 64-1-1, reverse complement, Verified ORF, "Cytoplasmic thioredoxin isoenzyme of the thioredoxin system which protects cells against oxidative and reductive stress, forms LMA1 complex with Pbi2p, acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritance" [yeast-030211-contam.fasta] TRX1 SGDID:S000004033, Chr XII from 232013-231702, Genome Release 64-2-1, reverse complement, Verified ORF, "Cytoplasmic thioredoxin isoenzyme; part of thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p; required for ER-Golgi transport and vacuole inheritance; with Trx2p, facilitates mitochondrial import of small Tims Tim9p, Tim10p, Tim13p by maintaining them in reduced form; abundance increases iunder DNA replication stress; TRX1 has a paralog, TRX2, that arose from the whole genome duplication" [20141208_orf_trans.fasta] TR985\|c0_g1_i1\|g.712 ORF TR985\|c0_g1_i1\|g.712 TR985\|c0_g1_i1\|m.712 type:complete len:104 (+) TR985\|c0_g1_i1:2147-2458(+) [Y12_S_cerevisiae-Sep2015-contam.fasta] TR5385\|c0_g1_i1\|g.3689 ORF TR5385\|c0_g1_i1\|g.3689 TR5385\|c0_g1_i1\|m.3689 type:complete len:104 (+) TR5385\|c0_g1_i1:2625-2936(+) [DBVPG6044_S_cerevisiae-Sep2015-contam.fasta] TR5385\|c0_g2_i1\|g.3691 ORF TR5385\|c0_g2_i1\|g.3691 TR5385\|c0_g2_i1\|m.3691 type:complete len:104 (+) TR5385\|c0_g2_i1:2625-2936(+) [DBVPG6044_S_cerevisiae-Sep2015-contam.fasta] YLR043C SGDID:S000004033, Chr XII from 232013-231702, Genome Release 64-1-1, reverse complement, Verified ORF, "Cytoplasmic thioredoxin isoenzyme of the thioredoxin system which protects cells against oxidative and reductive stress, forms LMA1 complex with Pbi2p, acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritance" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta] asmbl_8420\|g.6199 ORF asmbl_8420\|g.6199 asmbl_8420\|m.6199 type:complete len:104 (+) asmbl_8420:2095-2406(+) [DBVPG6044_Trinity_v2_2_0_PASA_6May2016-contam.fasta] asmbl_8597\|g.6270 ORF asmbl_8597\|g.6270 asmbl_8597\|m.6270 type:complete len:104 (+) asmbl_8597:273-584(+) [Y12_Trinity_v2_2_0_PASA_6May2016-contam.fasta] ID=asmbl_8570\|g.5256 ORF ID=asmbl_8570\|g.5256 ID=asmbl_8570\|m.5256 type:complete len:104 (+) ID=asmbl_8570:2095-2406(+) [DBVPG6044_quiverGenomes_Trinity_v2_2_0_PASA_2June2016-contam.fasta] ID=asmbl_8597\|g.5186 ORF ID=asmbl_8597\|g.5186 ID=asmbl_8597\|m.5186 type:complete len:104 (+) ID=asmbl_8597:273-584(+) [Y12_quiver_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
Organism:	Saccharomyces cerevisiae
Length:	103 amino acids
Gene Ontology:
Cellular Component:	cytosol [IDA] fungal-type vacuole [IPI]
Biological Process:	vacuole inheritance [IMP ] response to oxidative stress [ISS] ER to Golgi vesicle-mediated transport [IDA] retrograde vesicle-mediated transport, Golgi to ER [IDA] DNA-dependent DNA replication [IMP ] vacuole fusion, non-autophagic [IDA] sulfate assimilation [IGI]
Molecular Function:	thiol-disulfide exchange intermediate activity [ISS]

Sequence:
Sequence: [PDR BLAST] [ProtParam]	1 11 21 31 41 51 \| \| \| \| \| \| 1 MVTQFKTASE FDSAIAQDKL VVVDFYATWC GPCKMIAPMI EKFSEQYPQA DFYKLDVDEL 60 61 GDVAQKNEVS AMPTLLLFKN GKEVAKVVGA NPAAIKQAIA ANA

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		ADH1 ECM10 IPP1 MLC1 TRX1 TRX2 TSA1
View Details	Hazbun TR, et al. (2003)		AMN1 AXL2 IMH1 PEX19 PFK27 RAX2 RGT2 RIC1 RIX7 RPA190 SST2 TRX1 TRX2 YLR035C-A
View Details	Krogan NJ, et al. (2006)		AIM22 DPH1 DPH2 EFT2, EFT1 HGH1 MNN1 PGI1 RRG10 TRX1 YMR315W
View Details	Qiu et al. (2008)		GRX2 TRX1 TRX2 VMA9

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	RIX7	No Comments	Hazbun TR, et al. (2003)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	TRX1	Huh WK, et al. (2003)

Protein Structure Data

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Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..103]	PSI-BLAST	226.67837	Thioredoxin

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle