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Protein Overview: KAE1

General Information:
Name(s) found: KAE1 / YKR038C [SGD]
Description(s) found:
Found 10 descriptions.
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  • Highly conserved putative glycoprotease proposed to be involved in transcription as a component of the EKC protein complex with Bud32p, Cgi121p, Pcc1p, and Gon7p; also identified as a component of the KEOPS protein complex [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 421 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    nuclear chromatin [IDALink to PubMed article]
    EKC/KEOPS protein complex [IDALink to PubMed articleLink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: telomere maintenance [IPILink to PubMed article]
    positive regulation of transcription from RNA polymerase II promoter [IPILink to PubMed article]
    Molecular Function: chromatin DNA binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMSSRVTIFT SCNDAYIYLL REGNSQAFPN AVGSKMVNLN TIPPKNGRDY YIALGLEGSA  60
   61 NKLGVGIVKH PLLPKHANSD LSYDCEAEML SNIRDTYVTP PGEGFLPRDT ARHHRNWCIR 120
  121 LIKQALAEAD IKSPTLDIDV ICFTKGPGMG APLHSVVIAA RTCSLLWDVP LVGVNHCIGH 180
  181 IEMGREITKA QNPVVLYVSG GNTQVIAYSE KRYRIFGETL DIAIGNCLDR FARTLKIPNE 240
  241 PSPGYNIEQL AKKAPHKENL VELPYTVKGM DLSMSGILAS IDLLAKDLFK GNKKNKILFD 300
  301 KTTGEQKVTV EDLCYSLQEN LFAMLVEITE RAMAHVNSNQ VLIVGGVGCN VRLQEMMAQM 360
  361 CKDRANGQVH ATDNRFCIDN GVMIAQAGLL EYRMGGIVKD FSETVVTQKF RTDEVYAAWR 420
  421 D

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run KAE1 No Comments Hazbun TR, et al. (2003)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..170]
    [381..421]    		 Pcons 3.69 Hydroxyglutaryl-CoA dehydratase component A
    2 View Details [171..380] Pcons 3.69 Hydroxyglutaryl-CoA dehydratase component A


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle