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Protein Overview: ENO1

General Information:
Name(s) found: ENO1 / YGR254W [SGD]
Description(s) found:
Found 21 descriptions.
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  • Enolase I, a phosphopyruvate hydratase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is repressed in response to glucose [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 437 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed article]
    phosphopyruvate hydratase complex [IDALink to PubMed article]
    vacuole [IDALink to PubMed article]
    Biological Process: gluconeogenesis [IEPLink to PubMed article]
    regulation of vacuole fusion, non-autophagic [IDALink to PubMed article][IMPLink to PubMed article]
    glycolysis [IMPLink to PubMed article]
    Molecular Function: phosphopyruvate hydratase activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAVSKVYARS VYDSRGNPTV EVELTTEKGV FRSIVPSGAS TGVHEALEMR DGDKSKWMGK  60
   61 GVLHAVKNVN DVIAPAFVKA NIDVKDQKAV DDFLISLDGT ANKSKLGANA ILGVSLAASR 120
  121 AAAAEKNVPL YKHLADLSKS KTSPYVLPVP FLNVLNGGSH AGGALALQEF MIAPTGAKTF 180
  181 AEALRIGSEV YHNLKSLTKK RYGASAGNVG DEGGVAPNIQ TAEEALDLIV DAIKAAGHDG 240
  241 KIKIGLDCAS SEFFKDGKYD LDFKNPNSDK SKWLTGPQLA DLYHSLMKRY PIVSIEDPFA 300
  301 EDDWEAWSHF FKTAGIQIVA DDLTVTNPKR IATAIEKKAA DALLLKVNQI GTLSESIKAA 360
  361 QDSFAAGWGV MVSHRSGETE DTFIADLVVG LRTGQIKTGA PARSERLAKL NQLLRIEEEL 420
  421 GDNAVFAGEN FHHGDKL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ADH1 EFT2, EFT1 ENO1 FBA1 PDC1
    View Details Gavin AC, et al. (2006) ENO1 NAT1
    View Details Gavin AC, et al. (2002) ARD1 ASC1 ENO1 MIS1 MYO1 NAT1 PKC1 SSC1 UTP22
    View Details Qiu et al. (2008) ENO1 ENO2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run PSF2 No Comments Hazbun TR, et al. (2003)
    View Run NAF1 No Comments Hazbun TR, et al. (2003)
    View Run DSN1 No Comments Hazbun TR, et al. (2003)
    View Run TAM41 No Comments Hazbun TR, et al. (2003)
    View Run NSL1 No Comments Hazbun TR, et al. (2003)
    View Run PGA1 No Comments Hazbun TR, et al. (2003)
    View Run NOP9 No Comments Hazbun TR, et al. (2003)
    View Run KAE1 No Comments Hazbun TR, et al. (2003)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run ASF1 3912: TAP-tagged, strain background includes hpc2(delta) Green EM, et al (2005)
    View Run RLF2 cac1: TAP-tagged Green EM, et al (2005)
    View Run MLP2 #20 Asynchronous Prep1-TiO2 Phosphopeptide enrichment, PartB Keck JM, et al. (2011)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #22 Asynchronous Prep2-IMAC Phosphopeptide enrichment B1-2 Keck JM, et al. (2011)
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)
    View Run MLP2 #04 Alpha Factor Prep2 Keck JM, et al. (2011)
    View Run MLP2 #13 Mitotic Prep2-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #10 Mitotic Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)
    View Run MLP2 #06 Alpha Factor Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #05 Alpha Factor Prep2-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #07 Alpha Factor Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run None Entered #17 Mitotic Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data ENO1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..35]
    [47..127]    		 PSI-BLAST 11000.0 Enolase
    2 View Details [36..46]
    [128..437]    		 PSI-BLAST 11000.0 Enolase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphopyruvate hydratase activity
    		•  10.7545435133049 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.33007926350873 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.15117039251634 bayes_pls_golite062009
  • DNA binding
    		•  1.97129250063131 bayes_pls_golite062009
  • binding
    		•  1.95079397144714 bayes_pls_golite062009
  • intramolecular lyase activity
    		•  1.72552670956901 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.36446664329679 bayes_pls_golite062009
  • transcription factor activity
    		•  1.24065454553451 bayes_pls_golite062009
  • lyase activity
    		•  0.953241510600178 bayes_pls_golite062009
  • carbon-oxygen lyase activity
    		•  0.908937887773213 bayes_pls_golite062009
  • hydro-lyase activity
    		•  0.874016693867333 bayes_pls_golite062009
  • catalytic activity
    		•  0.534516847146079 bayes_pls_golite062009
  • protein binding
    		•  0.476896736636797 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle