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Catalysis of the reaction: trans-feruloyl-CoA + H2O = 4-hydroxy-3-methoxyphenyl-beta-hydroxypropionyl-CoA. Catalysis of the reaction: D-altronate = 2-dehydro-3-deoxy-D-gluconate + H2O. Catalysis of the reaction: (5R)-menth-2-enone + H2O = (5R)-3-hydroxymenthone. Catalysis of the reaction: N-cyclohexylformamide = cyclohexyl isocyanide + H2O. Catalysis of the reaction: urea = cyanamide + H2O. Catalysis of the reaction: D-glutamate = 5-oxo-D-proline + H2O. Catalysis of the reaction: an aliphatic amide = a nitrile + H2O. Catalysis of the reaction: dTDP-glucose = dTDP-4-dehydro-6-deoxy-D-glucose + H2O. Catalysis of the reaction: 13(S)-hydroperoxylinolenate = 12,13(S)-epoxylinolenate + H2O. Catalysis of the reaction: citrate = cis-aconitate + H2O = isocitrate; i.e. the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate. Catalysis of the reaction: 2-phospho-D-glycerate = phosphoenolpyruvate + H2O. Catalysis of the reaction: L-aspartate-4-semialdehyde + pyruvate = dihydrodipicolinate + 2 H2O. Catalysis of the reaction: 4,5-dihydro-4-oxo-5-imidazolepropanoate = urocanate + H2O. null Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + retinol = adenosine 3',5'-bisphosphate + anhydroretinol. Catalysis of the reaction: methylisocitrate = H2O + 2-methylaconitate. Catalysis of the reaction: cis-2-oxohept-3-ene-1,7-dioate + H2O = 2,4-dihydroxy-hept-trans-2-ene-1,7-dioate. Catalysis of the reaction: 2-hydroxyisobutyrate = H2O + methacrylate. Catalysis of the reaction: citramalyl-CoA = itaconyl-CoA + H2O. Catalysis of the reaction: 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O. Catalysis of the reaction: lactoyl-CoA = acryloyl-CoA + H2O. Catalysis of the reaction: acetaldehyde = acetylene + H2O. Catalysis of the reaction: hydroxymethylbilane = uroporphyrinogen-III + H2O. Catalysis of the reaction: 2-oxo-3-enoate-4-benzenoid + H2O = pyruvate + benzaldehyde derivative. Substrates are (3E )-4-(5-amino-2-hydroxy-phenyl)-2-oxo-but-3-ene-1-oic-acid (forms 5-aminosalicylaldehyde) and trans-o-hydroxybenzylidenepyruvate (forms salicylaldehyde). Catalysis of the reaction: D-gluconate = 2-dehydro-3-deoxy-D-gluconate + H2O. Catalysis of the reaction: (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4-alpha-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H2O. Catalysis of the reaction: alkene-CoA + H2O = alcohol-CoA. Substrates are crotonoyl-CoA (producing 3-hydroxyacyl-CoA) and 2,3-didehydro-pimeloyl-CoA (producing 3-hydroxypimeloyl-CoA). Catalysis of the reaction: kievitone hydrate = kievitone + H2O. Catalysis of the reaction: 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon + H2O = CH2CHCOCOOH + 2,5,6-trihydroxy-3-methylpyridine. Catalysis of the reaction: L-serine + 1-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O. Catalysis of the reaction: 2-hydroxydec-2,4-diene-1,10-dioate + H2O = (2Z)-2,4-dihydroxydec-2-enedioate. Catalysis of the reaction: (3R)-3-hydroxybutanoyl-CoA = crotonoyl-CoA + H2O. Catalysis of the reaction: phaseollidin hydrate = H2O + phaseollidin. Catalysis of the reaction: 16-alpha-hydroxyprogesterone = H2O + 16-dehydroprogesterone. Catalysis of the reaction: protoaphin aglucone = H2O + xanthoaphin. Catalysis of the reaction: (R)-2-methylmalate = 2-methylmaleate + H2O. Catalysis of the reaction: (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide + ATP = phosphate + NADH + ADP. Catalysis of the reaction: 3-dehydroquinate = 3-dehydroshikimate + H2O. Catalysis of the reaction: (3R)-3-hydroxybutanoyl-[acyl-carrier protein] = H2O + but-2-enoyl-[acyl-carrier protein]. Catalysis of the reaction: (R)-10-hydroxystearate = oleate + H2O. Catalysis of the reaction: CDP-glucose = CDP-4-dehydro-6-deoxy-D-glucose + H2O. Catalysis of the reaction: 4-methyloct-2-enoyl-CoA + H2O = 3-hydroxy-4-methyloctanoyl-CoA. Catalysis of the reaction: naphthyl-2-methylene-succinyl-CoA + H2O = naphthyl-2-hydroxymethyl-succinyl-CoA. Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. Catalysis of the reaction: 3-isopropylmalate = 2-isopropylmaleate + H2O. Catalysis of the reaction: glycerol = 3-hydroxypropanal + H2O. Catalysis of the reaction: 2-dehydro-3-deoxy-L-arabinonate = H2O + 2,5-dioxopentanoate. Catalysis of the reaction: 5-keto-4-deoxy-D-glucarate = CO2 + H2O + 2,5-dioxopentanoate. null Catalysis of the reaction: limonene + H2O = alpha-terpineol. Catalysis of the reaction: propane-1,2-diol = propanal + H2O. Catalysis of the reaction: L-arabinonate = 2-dehydro-3-deoxy-L-arabinonate + H2O. Catalysis of the reaction: (S)-2-methylmalate = 2-methylfumarate + H2O. Catalysis of the reaction: L-erythro-3-methylmalyl-CoA = mesaconyl-CoA + H2O. Catalysis of the reaction: L-fuconate = 2-dehydro-3-deoxy-L-fuconate + H2O. Catalysis of the reaction: cyclohex-1,5-dienecarbonyl-CoA + H2O = 6-hydroxycyclohex-1-ene-1-carbonyl-CoA. Catalysis of the reaction: (9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate = (9Z)-(13S)-12,13-epoxyoctadeca-9,11-dienoate + H2O. Catalysis of the breakage of a carbon-oxygen bond. Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. Catalysis of the reaction: D-xylonate = 2-dehydro-3-deoxy-D-xylonate + H2O. Catalysis of the reaction: perillyl-CoA + H2O = 2-hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA. Catalysis of the reaction: GDP-mannose = GDP-4-dehydro-6-deoxy-D-mannose + H2O. Catalysis of the reaction: CH3-CHOH-CH2-[CH2]n-CO-[acyl-carrier protein] = H2O + CH3-CH-CH-[CH2]n-CO-[acyl-carrier protein]. Catalysis of the reaction: 6-phospho-D-gluconate = 2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O. Catalysis of the reaction: (2E,4E)-2-hydroxyhexa-2,4-dienoate + H2O = 4-hydroxy-2-oxohexanoate. Catalysis of the reaction: 2-succinylbenzoate + H2O = 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate. Catalysis of the reaction: 2 5-aminolevulinate = porphobilinogen + 2 H2O. Catalysis of the reaction: 3-hydroxypropenoate = propynoate + H2O. Catalysis of the reaction: D-galactarate = 5-dehydro-4-deoxy-D-glucarate + H2O. Catalysis of the reaction: 5-chloro-2-oxopent-4-enoate + H2O = 5-chloro-4-hydroxy-2-oxopentanate. Catalysis of the reaction: 1-(4-hydroxyphenyl)-2-aminoethanol = (4-hydroxyphenyl)acetaldehyde + NH3. Catalysis of the reaction: 3-hydroxypropionyl-CoA = acrylyl-CoA + H2O. Catalysis of the reaction: prephenate = phenylpyruvate + H2O + CO2. Catalysis of the reaction: (3R)-3-hydroxytetradecanoyl-[acyl-carrier protein] = tetradecenoyl-[acyl-carrier protein] + H2O. Catalysis of the reaction: scytalone = 1,3,8-trihydroxynaphthalene + H2O. Catalysis of the reaction: trans-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate + H2O = pyruvate + 3-hydroxy-2-formylbenzothiophene. Catalysis of the reaction: cyclohex-1-ene-1-carboxyl-CoA + H2O = 2-hydroxycyclohexane-1-carboxyl-CoA. Catalysis of the reaction: 2,4,4-trimethylpent-2-enoyl-CoA + H2O = 2,4,4-trimethyl-3-hydroxypentanoyl-CoA. Catalysis of the reaction: 1,2-bis(4-hydroxyphenyl)-2-propanol = 4,4'-dihydroxy-alpha-methylstilbene + H2O. Catalysis of the reaction: D-galactonate = 2-dehydro-3-deoxy-D-galactonate + H2O. Catalysis of the reaction: E-phenylitaconyl-CoA + H2O = (hydroxymethylphenyl)succinyl-CoA. Catalysis of the reaction: D-glucarate = 5-dehydro-4-deoxy-D-glucarate + H2O. Catalysis of the reaction: UDP-glucose = UDP-4-dehydro-6-deoxy-D-glucose + H2O. Catalysis of the reaction: 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA = 3-(4-methylpent-3-en-1-yl)-pent-2-enedioyl-CoA + H2O. Catalysis of the reaction: formamide = cyanide + H2O. Catalysis of the reaction: 4-(2-aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde = (S)-norcoclaurine + H2O. Catalysis of the reaction: trans-4-(1'-hydroxynaphth-2'-yl)-2-oxobut-3-enoate + H2O = pyruvate + 1-hydroxy-2-naphthaldehyde. Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O. Catalysis of the reaction: 6-hydroxycyclohex-1-ene-1-carboxyl-CoA + H2O = 2,6-dihydroxycyclohexane-1-carboxyl-CoA. Catalysis of the reaction: 2-keto-3-deoxygluconate = D-glyceraldehyde + pyruvate. Catalysis of the reaction: 2-keto-3-deoxygalactonate = D-glyceraldehyde + pyruvate. Catalysis of the formation of vinylacetyl-CoA from 4-hydroxybutyryl-CoA. Catalysis of the reaction: L-asparagine = 3-cyanoalanine + H2O. Catalysis of the reaction: L-arogenate = L-phenylalanine + H2O + CO2. Catalysis of the reaction: (R)-malate = maleate + H2O. Catalysis of the reaction: (S)-malate = fumarate + H2O. Catalysis of the reaction: 3-oxopropanoate = propynoate + H2O. Catalysis of the reaction: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O. Catalysis of the reaction: (2R,3S)-2,3-dimethylmalate = dimethylmaleate + H2O. Catalysis of the reaction: L-serine + L-homocysteine = cystathionine + H2O. Catalysis of the reaction: 2,4,6/3,5-pentahydroxycyclohexanone = 3,5/4-trihydroxycyclohexa-1,2-dione + H2O. Catalysis of the reaction: 1-(4-hydroxyphenyl)-2-(methylamino)ethanol = (4-hydroxyphenyl)acetaldehyde + methylamine. Catalysis of the reaction: 3R-hydroxyacyl-CoA = 2E-enoyl-CoA + H2O. Catalysis of the reaction: 2-hydroxybutane-1,2,3-tricarboxylate = (Z)-but-2-ene-1,2,3-tricarboxylate + H2O. Catalysis of the reaction: H2CO3 = CO2 + H2O. Catalysis of the reaction: citrate = cis-aconitate + H2O. Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2-enoyl-CoA + H2O. Catalysis of the reaction: 2-methylhex-2-enoyl-CoA + H2O = 3-hydroxy-2-methylhexanoyl-CoA. Catalysis of the reaction: endosulfan diol = endosulfan ether + H2O. Catalysis of the reaction: trans-L-3-hydroxyproline = H2O + delta(1)-pyrroline_2-carboxylate. Catalysis of the reaction: (S,S)-tartrate = oxaloacetate + H2O. Catalysis of the reaction: uracil + D-ribose 5-phosphate = pseudouridine 5'-phosphate + H2O. Catalysis of the reaction: 1,5-anhydro-D-fructose = 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose + H2O. Catalysis of the reaction: 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate = (E)-4-oxobut-1-ene-1,2,4-tricarboxylate + H2O. Catalysis of the reaction: 5-alpha-ergosta-7,22-diene-3-beta,5-diol = ergosterol + H2O. Catalysis of the reaction: L-rhamnonate = 2-dehydro-3-deoxy-L-rhamnonate + H2O. Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = trans-3-methylglutaconyl-CoA + H2O. Catalysis of the reaction: 2-hydroxybutane-1,2,4-tricarboxylate = but-1-ene-1,2,4-tricarboxylate + H2O. Catalysis of the reaction: 2,7,4'-trihydroxyisoflavanone = daidzein + H2O. Catalysis of the reaction: 7alpha,12alpha-dihydroxy-3-oxochol-4-enoate = 12alpha-hydroxy-3-oxochola-4,6-dienoate + H2O. Catalysis of the reaction: 3-dehydroshikimate = 3,4-dihydroxybenzoate (protocatechuate) + H2O. 3,4-dihydroxybenzoate is also known as protocatechuate. Catalysis of the reaction: D-fuconate = 2-dehydro-3-deoxy-D-fuconate + H2O. Catalysis of the dehydration of 2-hydroxyglutaryl-CoA to glutaconyl-CoA. Catalysis of the reaction: L-serine + pyrazole = 3-(pyrazol-1-yl)-L-alanine + H2O. Catalysis of the reaction: (R,R)-tartrate = oxaloacetate + H2O. Catalysis of the reaction: (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA = (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA + H2O. Catalysis of the reaction: L-carnitine = 4-(trimethylammonio)but-2-enoate + H2O. Catalysis of the reactions: 1,5-anhydro-D-fructose = 2-hydroxy-2-(hydroxymethyl)-2H-pyran-3(6H)-one + H2O (overall reaction), (1a) 1,5-anhydro-D-fructose = 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose + H2O and (1b) 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose = 2-hydroxy-2-(hydroxymethyl)-2H-pyran-3(6H)-one. Catalysis of the reaction: N4-acetyl-L-2,4-diaminobutanoate = L-ectoine + H2O. Catalysis of the reaction: D-arabinonate = 2-dehydro-3-deoxy-D-arabinonate + H2O. Catalysis of the reaction: 4-hydroxy-2-oxopentanoate = 2-oxopent-4-enoate + H2O. Catalysis of the hydration of mesaconyl-CoA to beta-methylmalyl-CoA. Catalysis of the reaction: methylthioribulose-1-phosphate = 2,3-diketo-5-methylthio-1-phosphopentane + H2O. Catalysis of the reaction: S-methyl-5-thio-D-ribulose 1-phosphate = 5-(methylthio)-2,3-dioxopentyl phosphate + H2O. Catalysis of the reaction: D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: hydro-lyase activity
Acc: GO:0016836
Aspect: Molecular Function
Desc: Catalysis of the cleavage of a carbon-oxygen bond by elimination of water.
Proteins in PDR annotated with:
   This term: 48 [Search]
   Term or descendants: 662 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0016836 - hydro-lyase activity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle