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Protein Overview: ARD1

General Information:
Name(s) found: ARD1 / YHR013C [SGD]
Description(s) found:
Found 32 descriptions.
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  • Subunit of N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); acetylates many proteins and thus affects telomeric silencing, cell cycle, heat-shock resistance, mating, and sporulation; human Ard1p levels are elevated in cancer cells [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 238 amino acids

    Gene Ontology:
    Cellular Component: NatA complex [IDALink to PubMed article][TASLink to PubMed article]
    Biological Process: telomere maintenance [IMPLink to PubMed article]
    N-terminal protein amino acid acetylation [IDALink to PubMed article][IMPLink to PubMed article]
    Molecular Function: peptide alpha-N-acetyltransferase activity [IDALink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPINIRRATI NDIICMQNAN LHNLPENYMM KYYMYHILSW PEASFVATTT TLDCEDSDEQ  60
   61 DENDKLELTL DGTNDGRTIK LDPTYLAPGE KLVGYVLVKM NDDPDQQNEP PNGHITSLSV 120
  121 MRTYRRMGIA ENLMRQALFA LREVHQAEYV SLHVRQSNRA ALHLYRDTLA FEVLSIEKSY 180
  181 YQDGEDAYAM KKVLKLEELQ ISNFTHRRLK ENEEKLEDDL ESDLLEDIIK QGVNDIIV

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ARD1 NAT1 NAT5
    View Details (MIPS) Mewes HW, et al. (2004) ARD1 NAT1
    View Details Krogan NJ, et al. (2006) ARD1 NAT1 NAT5 RIM8
    View Details Gavin AC, et al. (2002) ARD1 ASC1 ENO1 MIS1 MYO1 NAT1 UTP22
    View Details Qiu et al. (2008) ARD1 MAK10 MAK3 MDM20 NAT1 NAT3 NAT5

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data ARD1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..238] PSI-BLAST 9.221849 Glucosamine-phoshate N-acetyltransferase GNA1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • N-acetyltransferase activity
    		•  6.09290029352595 bayes_pls_golite062009
  • N-acyltransferase activity
    		•  6.08913516066746 bayes_pls_golite062009
  • acetyltransferase activity
    		•  5.86411968036951 bayes_pls_golite062009
  • histone acetyltransferase activity
    		•  5.85159161781386 bayes_pls_golite062009
  • lysine N-acetyltransferase activity
    		•  5.85159161781386 bayes_pls_golite062009
  • acyltransferase activity
    		•  4.72881921515185 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  4.70793039001114 bayes_pls_golite062009
  • transferase activity, transferring acyl groups other than amino-acyl groups
    		•  4.69837915971204 bayes_pls_golite062009
  • transferase activity
    		•  3.5778020729894 bayes_pls_golite062009
  • myristoyltransferase activity
    		•  3.50779447340192 bayes_pls_golite062009
  • glycylpeptide N-tetradecanoyltransferase activity
    		•  3.50779447340192 bayes_pls_golite062009
    		• 3.43995513266627 bayes_pls_golite062009
  • catalytic activity
    		•  1.97933499002461 bayes_pls_golite062009
  • binding
    		•  1.07749536895426 bayes_pls_golite062009
  • histone binding
    		•  0.582104626133107 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.522132859536345 bayes_pls_golite062009
  • protein binding
    		•  0.098756769132141 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.0766125702622449 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle