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Protein Overview: PKC1

General Information:
Name(s) found: PKC1 / YBL105C [SGD]
Description(s) found:
Found 21 descriptions.
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  • Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC) [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1151 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoskeleton [IDALink to PubMed article]
    site of polarized growth [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: signal transduction [IMPLink to PubMed article]
    cellular cell wall organization [IMPLink to PubMed article]
    actin filament organization [IGILink to PubMed article]
    intracellular protein kinase cascade [IMPLink to PubMed article]
    protein amino acid phosphorylation [IDALink to PubMed article]
    Molecular Function: protein kinase C activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFSQLEQNI KKKIAVEENI IRGASALKKK TSNVMVIQKC NTNIREARQN LEYLEDSLKK  60
   61 LRLKTAQQSQ GENGSEDNER FNSKEYGFLS TKSPNEHIFS RLDLVKYDCP SLAQRIQYML 120
  121 QQLEFKLQVE KQYQEANTKL TKLYQIDGDQ RSSSAAEGGA MESKYRIQML NKALKKYQAI 180
  181 NVDFDQFKHQ PNDIMDNQQP KFRRKQLTGV LTIGITAARD VDHIQSPMFA RKPESYVTIK 240
  241 IDDTIKARTK PSRNDRWSED FQIPVEKGNE IEITVYDKVN DSLIPVAIMW LLLSDIAEEI 300
  301 RKKKAGQTNE QQGWVNASNI NGGSSLASEE GSTLTSTYSN SAIQSTSAKN VQGENTSTSQ 360
  361 ISTNSWFVLE PSGQILLTLG FHKSSQIERK QLMGGLHRHG AIINRKEEIF EQHGHHFVQK 420
  421 SFYNIMCCAY CGDFLRYTGF QCQDCKFLCH KKCYTNVVTK CIAKTSTDTD PDEAKLNHRI 480
  481 PHRFLPTSNR GTKWCCHCGY ILPWGRHKVR KCSECGIMCH AQCAHLVPDF CGMSMEMANK 540
  541 ILKTIQDTKR NQEKKKRTVP SAQLGSSIGT ANGSDLSPSK LAERANAPLP PQPRKHDKTP 600
  601 SPQKVGRDSP TKQHDPIIDK KISLQTHGRE KLNKFIDENE AYLNFTEGAQ QTAEFSSPEK 660
  661 TLDPTSNRRS LGLTDLSIEH SQTWESKDDL MRDELELWKA QREEMELEIK QDSGEIQEDL 720
  721 EVDHIDLETK QKLDWENKND FREADLTIDS THTNPFRDMN SETFQIEQDH ASKEVLQETV 780
  781 SLAPTSTHPS RTTDQQSPQK SQTSTSAKHK KRAAKRRKVS LDNFVLLKVL GKGNFGKVIL 840
  841 SKSKNTDRLC AIKVLKKDNI IQNHDIESAR AEKKVFLLAT KTKHPFLTNL YCSFQTENRI 900
  901 YFAMEFIGGG DLMWHVQNQR LSVRRAKFYA AEVLLALKYF HDNGVIYRDL KLENILLTPE 960
  961 GHIKIADYGL CKDEMWYGNR TSTFCGTPEF MAPEILKEQE YTKAVDWWAF GVLLYQMLLC1020
 1021 QSPFSGDDED EVFNAILTDE PLYPIDMAGE IVQIFQGLLT KDPEKRLGAG PRDADEVMEE1080
 1081 PFFRNINFDD ILNLRVKPPY IPEIKSPEDT SYFEQEFTSA PPTLTPLPSV LTTSQQEEFR1140
 1141 GFSFMPDDLD L

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) FOL3 PKC1 SSL2 TYR1
    View Details Gavin AC, et al. (2002) ENO1 PKC1
    View Details Qiu et al. (2008) AKL1 PKC1 SSK2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #34 Asynchronous SPB prep Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PKC1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..95] Pfam 21.0 Hr1 repeat No confident structure predictions are available.
    2 View Details [96..192] ORFEUS 9.8 Effector domain of the protein kinase pkn/prk1
    3 View Details [193..333] PSI-BLAST 20.221849 Domain from protein kinase C epsilon
    4 View Details [334..387] deduced N/A No confident structure predictions are available.
    5 View Details [388..464] Pfam 17.30103 Phorbol esters/diacylglycerol binding domain (C1 domain) No confident structure predictions are available.
    6 View Details [465..546] PSI-BLAST 47.522879 Protein kinase c-gamma
    7 View Details [547..627] deduced N/A No confident structure predictions are available.
    8 View Details [628..797] PSI-BLAST 12.154902 C2 domain from protein kinase c (alpha)
    9 View Details [798..873]
    [890..906]
    [1104..1151]    		 PSI-BLAST 690.228787 cAMP-dependent PK, catalytic subunit
    10 View Details [874..889]
    [907..1103]    		 PSI-BLAST 690.228787 cAMP-dependent PK, catalytic subunit

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • binding
    		•  2.71288992341677 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  2.07238897772131 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.02888738926089 bayes_pls_golite062009
  • kinase activity
    		•  2.00903309297046 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.83466699022067 bayes_pls_golite062009
  • protein kinase activity
    		•  1.61903873760762 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.54948980710962 bayes_pls_golite062009
  • transferase activity
    		•  1.45394179515146 bayes_pls_golite062009
  • DNA binding
    		•  1.42056177729872 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.25050856744516 bayes_pls_golite062009
  • signal transducer activity
    		•  1.25050856744516 bayes_pls_golite062009
  • protein binding
    		•  1.21002143294224 bayes_pls_golite062009
  • GTPase regulator activity
    		•  1.12412426198961 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  1.10707685935826 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.93378879973188 bayes_pls_golite062009
  • transcription factor activity
    		•  0.839889809493374 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.717794523788476 bayes_pls_golite062009
  • guanyl-nucleotide exchange factor activity
    		•  0.6091533221871 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.507633651875793 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  0.442062495186646 bayes_pls_golite062009
  • kinase binding
    		•  0.409606963040614 bayes_pls_golite062009
  • catalytic activity
    		•  0.216721136299042 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.132870203047992 bayes_pls_golite062009
    5
    Term Confidence Notes
  • binding
    		•  2.79128751898373 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  2.10625597744594 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.07497340861199 bayes_pls_golite062009
  • kinase activity
    		•  2.03632850156074 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.8531437045627 bayes_pls_golite062009
  • protein kinase activity
    		•  1.62921423829738 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.54797684894025 bayes_pls_golite062009
  • transferase activity
    		•  1.4550521488922 bayes_pls_golite062009
  • DNA binding
    		•  1.42215436462553 bayes_pls_golite062009
  • GTPase regulator activity
    		•  1.39167263636091 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  1.37139209958305 bayes_pls_golite062009
  • protein binding
    		•  1.29100556128076 bayes_pls_golite062009
  • signal transducer activity
    		•  1.25507073225414 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.25507073225414 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.956859696337723 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.911061212692491 bayes_pls_golite062009
  • guanyl-nucleotide exchange factor activity
    		•  0.907368864863833 bayes_pls_golite062009
  • transcription factor activity
    		•  0.85055461881385 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  0.661240850692236 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.6452191274371 bayes_pls_golite062009
  • kinase binding
    		•  0.494958567742569 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.38335246506929 bayes_pls_golite062009
  • catalytic activity
    		•  0.194464246602439 bayes_pls_golite062009
  • lipid binding
    		•  0.170968368793169 bayes_pls_golite062009
    6 No functions predicted.
    7
    Term Confidence Notes
  • binding
    		•  2.77482286467294 bayes_pls_golite062009
  • phospholipid binding
    		•  2.74013385479058 bayes_pls_golite062009
  • neurexin binding
    		•  1.99616093461872 bayes_pls_golite062009
  • calcium-dependent phospholipid binding
    		•  1.85892769686753 bayes_pls_golite062009
  • lipid binding
    		•  1.79802914584378 bayes_pls_golite062009
  • protein binding
    		•  1.33917246836907 bayes_pls_golite062009
  • transporter activity
    		•  1.2628067945512 bayes_pls_golite062009
  • signal transducer activity
    		•  1.10701462579828 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.10701462579828 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.816751946072324 bayes_pls_golite062009
  • receptor activity
    		•  0.516117489846513 bayes_pls_golite062009
  • SNARE binding
    		•  0.3731056408292 bayes_pls_golite062009
  • profilin binding
    		•  0.32399339703241 bayes_pls_golite062009
    8 No functions predicted.
    9 No functions predicted.
    10 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle