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Protein Overview: FOL3

General Information:
Name(s) found: FOL3 / YMR113W [SGD]
Description(s) found:
Found 25 descriptions.
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  • Dihydrofolate synthetase, involved in folic acid biosynthesis; catalyzes the conversion of dihydropteroate to dihydrofolate in folate coenzyme biosynthesis [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 427 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: folic acid and derivative biosynthetic process [IMPLink to PubMed article]
    Molecular Function: dihydrofolate synthase activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAIELGLSRI TKLLEHLGNP QNSLRVLHIA GTNGKGSVCT YLSSVLQQKS YQIGKFTTPH  60
   61 LVHVTDSITI NNKPIPLERY QNIRLQLEAL NKSHSLKCTE FELLTCTAFK YFYDVQCQWC 120
  121 VIEVGLGGRL DATNVIPGAN KACCGITKIS LDHESFLGNT LSEISKEKAG IITEGVPFTV 180
  181 IDGTNEASVI NVVKERCKAL GSELSVTDSQ LNGNMIDTNS WGCFDLAKLP LNGEYQIFNL 240
  241 RVAMGMLDYL QMNELIDITK NEVSTRLAKV DWPGRLYRMD YRFDKVSNRT VPILMDGAHN 300
  301 GSAAVELVKY LRKEYGNQPL TFVMAVTHGK NLEPLLQPLL RPIDQVILTR FNNVEGMPWI 360
  361 HATDPEEIKD FILTQGYTKE IVIENDLHQV LPSLAHVSDE QRRPIVVCGS LYLCGELLRI 420
  421 HNSHLRN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) FOL3 PKC1 SSL2 TYR1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data FOL3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..272] PSI-BLAST 466.40824 Folylpolyglutamate synthetase, C-terminal domain; Folylpolyglutamate synthetase
    2 View Details [273..427] PSI-BLAST 466.40824 Folylpolyglutamate synthetase, C-terminal domain; Folylpolyglutamate synthetase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • acid-amino acid ligase activity
    		•  4.03401034724886 bayes_pls_golite062009
  • tetrahydrofolylpolyglutamate synthase activity
    		•  3.94486215528378 bayes_pls_golite062009
  • ligase activity
    		•  3.80574681739772 bayes_pls_golite062009
  • catalytic activity
    		•  2.66037860982128 bayes_pls_golite062009
  • dihydrofolate synthase activity
    		•  2.50201834836027 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  1.96801058335544 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle