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Protein Overview: YRA1

General Information:
Name(s) found: YRA1 / YDR381W [SGD]
Description(s) found:
Found 28 descriptions.
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  • RNA binding protein required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; functionally redundant with Yra2p, another REF family member [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 226 amino acids

    Gene Ontology:
    Cellular Component: transcription export complex [IPILink to PubMed article]
    Biological Process: mRNA export from nucleus [IGILink to PubMed article]
    Molecular Function: RNA binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSANLDKSLD EIIGSNKAGS NRARVGGTRG NGPRRVGKQV GSQRRSLPNR RGPIRKNTRA  60
   61 PPNAVARVAK LLDTTREVKV NVEGLPRDIK QDAVREFFAS QVGGVQRVLL SYNERGQSTG 120
  121 MANITFKNGE LARRAVERFN GSPIDGGRSR LRLNLIVDPN QRPVKSLADR IKAMPQKGGN 180
  181 APRPVKRGPN RKAAMAKSQN KPKREKPAKK SLEDLDKEMA DYFEKK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) GBP2 RPS4B, RPS4A YRA1
    View Details Krogan NJ, et al. (2006) ALG5 BRE5 CSN12 CUP2 DBP7 LUG1 MET10 MSC7 MSE1 NOP53 NPY1 PBP4 RPF2 RRS1 SAS5 UME6 YGR126W YHR127W YPR045C YRA1
    View Details Gavin AC, et al. (2002) ADH1 AHA1 ATP11 BLM10 CAF130 CAF40 CCR4 CCT6 CDC36 CDC39 CDC55 CIN1 COP1 DAM1 DBP9 ECM29 ERG13 EST3 FAS2 GCN1 GFA1 GIN4 GUS1 HHF1, HHF2 HMO1 HOS2 HOS4 HTZ1 IML1 INO4 KAP114 KAP95 KCC4 KEL1 LTE1 LYS12 MDS3 MOT2 MYO5 NAP1 NBA1 NIS1 NOT3 NOT5 NUD1 PBP2 PDA1 PDB1 PDC1 PFK1 PGI1 POL1 POL12 POP2 PPH21 PPH22 PRE1 PRE10 PRE2 PRE3 PRE4 PRE5 PRE6 PRE7 PRE8 PRE9 PRI1 PRI2 PSE1 PUP1 PUP2 PUP3 RAD1 RAD10 RGR1 RPT3 RPT5 RRD2 RRP12 RTS1 RTS3 RVB2 SAM1 SCL1 SEC27 SET3 SIF2 SLX9 SNT1 SPA2 SRP1 SSC1 TDH2 TDH3 TEF4 TFC7 TFP1 TPD3 ULP1 YBL104C YEF3 YFL006W YMR310C YOR1 YRA1 ZDS1 ZDS2
    View Details Ho Y, et al. (2002) AAC3 ADH2 ARP4 ASA1 ATE1 ATG17 ATG29 ATP3 CBF5 CBP2 CCM1 CDC16 CDC33 CDC5 CIC1 CIS1 CKA1 CKA2 CKB1 CKB2 CYS4 DBP10 DBP7 EAF1 ELA1 ENP2 EPL1 ERB1 ESA1 ESF1 ESF2 FOL2 FPR3 GBP2 GDE1 GRH1 HAP2 HAP5 HAS1 HHF1, HHF2 HHO1 HMO1 HOT1 HPR1 HRR25 HTB1 HTB2 ICP55 IMD1 IMD3 IPP1 ISA1 KRE33 KRI1 LAA1 LHP1 LOC1 MAM33 MES1 MFT1 MGM101 MKT1 MMS4 MRPL1 MSS116 MTQ1 MUS81 NAP1 NHP2 NMD5 NOC2 NOC3 NOP12 NOP16 NOP2 NOP56 NOP6 NOP7 NPL3 NSA2 NUG1 PDI1 PET127 PMA1 POB3 POL2 POL5 POR1 PRP43 PSE1 PUF6 PWP1 RAD53 RHR2 RLI1 RPC10 RPF2 RRP12 RRP14 RRP5 SAH1 SAP185 SAP190 SEC23 SFP1 SIT4 SPE3 SPT16 SSF1 SSK2 SUB2 TAF14 TAF4 THO2 THP2 TIF1, TIF2 TIF4631 TIF6 TIP41 TMA29 TOP2 TRA1 TRL1 TSR1 TUF1 UBI4 URB1 URB2 UTP10 UTP20 UTP22 VMR1 VPS73 WTM2 YCR087W YDR102C YHB1 YPP1 YRA1 YRA2 YTM1
    View Details Qiu et al. (2008) HPR1 MFT1 SUB2 THO2 THP2 YRA1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run NAF1 No Comments Hazbun TR, et al. (2003)
    View Run BOI1 Sample boi1 with gst from october 2005 McCusker D, et al (2007)
    View Run BOI1 Sample bob1 (2nd set) from october 2005 McCusker D, et al (2007)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data YRA1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..67] PSI-BLAST 46.154902 Nuclear ribonucleoprotein A1 (RNP A1, UP1)
    2 View Details [68..226] PSI-BLAST 46.154902 Nuclear ribonucleoprotein A1 (RNP A1, UP1)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • nucleic acid binding
    		•  4.51665560478175 bayes_pls_golite062009
  • binding
    		•  3.64400841800969 bayes_pls_golite062009
  • mRNA binding
    		•  3.27529715028622 bayes_pls_golite062009
  • RNA binding
    		•  2.92438188845619 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.7776932219095 bayes_pls_golite062009
  • DNA binding
    		•  1.65208390030564 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  1.44900283271761 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.44189759422835 bayes_pls_golite062009
  • protein binding
    		•  1.12215421354121 bayes_pls_golite062009
  • mRNA 3'-UTR binding
    		•  0.824614388276642 bayes_pls_golite062009
  • structural molecule activity
    		•  0.815302976466241 bayes_pls_golite062009
  • transcription factor activity
    		•  0.795084003256395 bayes_pls_golite062009
  • transporter activity
    		•  0.628672636801176 bayes_pls_golite062009
  • translation regulator activity
    		•  0.583455818533482 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.505106991526286 bayes_pls_golite062009
    		• 0.4921730944941 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.333822192939807 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.304235325881492 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.182749906784328 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.096231856558874 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.059732432409948 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.0510390778764699 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.0484248928275733 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle