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Protein Overview: BRE5

General Information:
Name(s) found: BRE5 / YNR051C [SGD]
Description(s) found:
Found 29 descriptions.
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  • Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 515 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: protein deubiquitination [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGVTVQDICF AFLQNYYERM RTDPSKLAYF YASTAELTHT NYQSKSTNEK DDVLPTVKVT  60
   61 GRENINKFFS RNDAKVRSLK LKLDTIDFQY TGHLHKSILI MATGEMFWTG TPVYKFCQTF 120
  121 ILLPSSNGST FDITNDIIRF ISNSFKPYVL TDASLSQSNE ENSVSAVEED KIRHESGVEK 180
  181 EKEKEKSPEI SKPKAKKETV KDTTAPTESS TQEKPIVDHS QPRAIPVTKE SKIHTETVPS 240
  241 STKGNHKQDE VSTEELGNVT KLNEKSHKAE KKAAPIKTKE GSVEAINAVN NSSLPNGKEV 300
  301 SDEKPVPGGV KEAETEIKPI EPQVSDAKES GNNASTPSSS PEPVANPPKM TWASKLMNEN 360
  361 SDRISKNNTT VEYIRPETLP KKPTERKFEM GNRRDNASAN SKNKKKPVFS TVNKDGFYPI 420
  421 YIRGTNGLRE EKLRSALEKE FGKVMRITAA DNFAVVDFET QKSQIDALEK KKKSIDGIEV 480
  481 CLERKTVKKP TSNNPPGIFT NGTRSHRKQP LKRKD

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) BRE5 FIT1 UBP3 ZEO1
    View Details Krogan NJ, et al. (2006) ALG5 BRE5 CSN12 CUP2 DBP7 LUG1 MET10 MSC7 MSE1 NOP53 NPY1 PBP4 RPF2 RRS1 SAS5 UME6 YGR126W YHR127W YPR045C YRA1
    View Details Gavin AC, et al. (2006) BRE5 UBP3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run NAF1 No Comments Hazbun TR, et al. (2003)
    View Run BIR1 No Comments Widlund PO, et al. (2005)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data BRE5 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..149] PSI-BLAST 9.522879 Nuclear transport factor-2 (NTF2)
    2 View Details [150..515] ORFEUS 14.63 Sec24

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  1.88422211140837 bayes_pls_golite062009
  • protein binding
    		•  1.34243535208605 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.28328198842973 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.797931524291551 bayes_pls_golite062009
  • protein kinase activity
    		•  0.622060011038738 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.528127152698506 bayes_pls_golite062009
  • kinase activity
    		•  0.401688821547236 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.16347882814309 bayes_pls_golite062009
  • structural molecule activity
    		•  0.123366004333113 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle