YRC Public Data Repository - Protein Structure Prediction

Protein:	BRE5
Organism:	Saccharomyces cerevisiae
Length:	515 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for BRE5.

Description	E-value	Query Range	Subject Range
BRE5 - Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde ... BRE5_YEAST - UBP3-associated protein BRE5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=BRE5 PE=1 S...	9.0E-56	[1..515]	[1..515]
gi\|8163674 - gi\|8163674\|gb\|AAF73795.1\|AF154026_1 surface protein PspC [Streptococcus pneumoniae]	2.0E-45	[38..421]	[75..486]
gi\|25509405, gi\|... - gi\|8163644\|gb\|AAF73779.1\| surface protein PspC [Streptococcus pneumoniae], pir\|\|H98120 choline bindi... gi\|15459699, gi\|... - gi\|15904036\|ref\|NP_359586.1\| choline binding protein A [Streptococcus pneumoniae R6], gi\|15459699\|gb... gi\|116515359, gi... - gi\|8163644\|gb\|AAF73779.1\|AF154012_1 surface protein PspC [Streptococcus pneumoniae], gi\|116515359\|re...	2.0E-41	[36..421]	[74..495]
ZAN_MOUSE - Zonadhesin OS=Mus musculus GN=Zan PE=1 SV=1	2.0E-41	[74..508]	[466..927]
gi\|16554449, gi\|... - gi\|16554449\|ref\|NP_003377.1\| zonadhesin isoform 3 [Homo sapiens], gi\|12667414\|gb\|AAK01433.1\|AF332977...	1.0E-39	[74..510]	[460..928]
IGA1A_STRPN - Immunoglobulin A1 protease OS=Streptococcus pneumoniae GN=iga PE=3 SV=1 IGA1A_STRPN - Immunoglobulin A1 protease OS=Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) GN=i...	1.0E-39	[25..448]	[313..738]

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Predicted Domain #1

Region A:
Residues: [1-149]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGVTVQDICF AFLQNYYERM RTDPSKLAYF YASTAELTHT NYQSKSTNEK DDVLPTVKVT  60
   61 GRENINKFFS RNDAKVRSLK LKLDTIDFQY TGHLHKSILI MATGEMFWTG TPVYKFCQTF 120
  121 ILLPSSNGST FDITNDIIRF ISNSFKPYV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	9.522879
Match:	1gy7A_
Description:	Nuclear transport factor-2 (NTF2)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	1.88422211140837	bayes_pls_golite062009
protein binding	1.34243535208605	bayes_pls_golite062009
nucleic acid binding	1.28328198842973	bayes_pls_golite062009
protein serine/threonine kinase activity	0.797931524291551	bayes_pls_golite062009
protein kinase activity	0.622060011038738	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.528127152698506	bayes_pls_golite062009
kinase activity	0.401688821547236	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.16347882814309	bayes_pls_golite062009
structural molecule activity	0.123366004333113	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [150-515]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LTDASLSQSN EENSVSAVEE DKIRHESGVE KEKEKEKSPE ISKPKAKKET VKDTTAPTES  60
   61 STQEKPIVDH SQPRAIPVTK ESKIHTETVP SSTKGNHKQD EVSTEELGNV TKLNEKSHKA 120
  121 EKKAAPIKTK EGSVEAINAV NNSSLPNGKE VSDEKPVPGG VKEAETEIKP IEPQVSDAKE 180
  181 SGNNASTPSS SPEPVANPPK MTWASKLMNE NSDRISKNNT TVEYIRPETL PKKPTERKFE 240
  241 MGNRRDNASA NSKNKKKPVF STVNKDGFYP IYIRGTNGLR EEKLRSALEK EFGKVMRITA 300
  301 ADNFAVVDFE TQKSQIDALE KKKKSIDGIE VCLERKTVKK PTSNNPPGIF TNGTRSHRKQ 360
  361 PLKRKD

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	14.63
Match:	1m2vB
Description:	Sec24
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: