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Protein Overview: MSC7

General Information:
Name(s) found: MSC7 / YHR039C [SGD]
Description(s) found:
Found 28 descriptions.
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  • Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defective in directing meiotic recombination events to homologous chromatids [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 644 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum [IDALink to PubMed article]
    Biological Process: reciprocal meiotic recombination [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKVYLNSDM INHLNSTVQA YFNLWLEKQN AIMRSQPQII QDNQKLIGIT TLVASIFTLY  60
   61 VLVKIISTPA KCSSSYKPVK FSLPAPEAAQ NNWKGKRSVS TNIWNPEEPN FIQCHCPATG 120
  121 QYLGSFPSKT EADIDEMVSK AGKAQSTWGN SDFSRRLRVL ASLHDYILNN QDLIARVACR 180
  181 DSGKTMLDAS MGEILVTLEK IQWTIKHGQR ALQPSRRPGP TNFFMKWYKG AEIRYEPLGV 240
  241 ISSIVSWNYP FHNLLGPIIA ALFTGNAIVV KCSEQVVWSS EFFVELIRKC LEACDEDPDL 300
  301 VQLCYCLPPT ENDDSANYFT SHPGFKHITF IGSQPVAHYI LKCAAKSLTP VVVELGGKDA 360
  361 FIVLDSAKNL DALSSIIMRG TFQSSGQNCI GIERVIVSKE NYDDLVKILN DRMTANPLRQ 420
  421 GSDIDHLENV DMGAMISDNR FDELEALVKD AVAKGARLLQ GGSRFKHPKY PQGHYFQPTL 480
  481 LVDVTPEMKI AQNEVFGPIL VMMKAKNTDH CVQLANSAPF GLGGSVFGAD IKECNYVANS 540
  541 LQTGNVAIND FATFYVCQLP FGGINGSGYG KFGGEEGLLG LCNAKSVCFD TLPFVSTQIP 600
  601 KPLDYPIRNN AKAWNFVKSF IVGAYTNSTW QRIKSLFSLA KEAS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ALG5 BRE5 CSN12 CUP2 DBP7 LUG1 MET10 MSC7 MSE1 NOP53 NPY1 PBP4 RPF2 RRS1 SAS5 UME6 YGR126W YHR127W YPR045C YRA1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data MSC7 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..67] deduced N/A No confident structure predictions are available.
    2 View Details [68..355]
    [554..644]    		 PSI-BLAST 1476.9897 Aldehyde reductase (dehydrogenase), ALDH
    3 View Details [356..553] PSI-BLAST 1476.9897 Aldehyde reductase (dehydrogenase), ALDH

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors
    		•  5.09598561374689 bayes_pls_golite062009
  • oxidoreductase activity
    		•  4.47226217021998 bayes_pls_golite062009
  • 1-pyrroline-5-carboxylate dehydrogenase activity
    		•  4.35175408702761 bayes_pls_golite062009
  • malonate-semialdehyde dehydrogenase (acetylating) activity
    		•  4.2273960318884 bayes_pls_golite062009
  • methylmalonate-semialdehyde dehydrogenase (acylating) activity
    		•  3.87605237828483 bayes_pls_golite062009
  • succinate-semialdehyde dehydrogenase [NAD(P)+] activity
    		•  3.64672165191647 bayes_pls_golite062009
  • 3-chloroallyl aldehyde dehydrogenase activity
    		•  3.37049090049734 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
    		•  3.2867555127991 bayes_pls_golite062009
  • benzaldehyde dehydrogenase activity
    		•  2.99564252244797 bayes_pls_golite062009
  • aldehyde dehydrogenase (NAD) activity
    		•  2.81851373615334 bayes_pls_golite062009
  • catalytic activity
    		•  2.80804701752928 bayes_pls_golite062009
  • glutamate-5-semialdehyde dehydrogenase activity
    		•  2.78416888468693 bayes_pls_golite062009
  • succinate-semialdehyde dehydrogenase activity
    		•  2.71501590413507 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH group of donors
    		•  2.70230501280821 bayes_pls_golite062009
  • aldehyde dehydrogenase [NAD(P)+] activity
    		•  2.43250909158896 bayes_pls_golite062009
  • aminobutyraldehyde dehydrogenase activity
    		•  2.35958138496479 bayes_pls_golite062009
  • acyl-CoA binding
    		•  2.26220696569489 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
    		•  1.6559690223037 bayes_pls_golite062009
  • retinal dehydrogenase activity
    		•  1.42867174920845 bayes_pls_golite062009
  • electron carrier activity
    		•  1.33390667257376 bayes_pls_golite062009
  • binding
    		•  1.06673666884196 bayes_pls_golite062009
  • retinoid binding
    		•  0.983782635681687 bayes_pls_golite062009
  • isoprenoid binding
    		•  0.900374761028287 bayes_pls_golite062009
  • protein binding
    		•  0.894945263794726 bayes_pls_golite062009
  • hydrolase activity
    		•  0.799513645745266 bayes_pls_golite062009
  • histidinol dehydrogenase activity
    		•  0.258030369394064 bayes_pls_golite062009
  • benzaldehyde dehydrogenase (NAD+) activity
    		•  0.23487570676521 bayes_pls_golite062009
  • transferase activity
    		•  0.227457515645966 bayes_pls_golite062009
  • kinase activity
    		•  0.225459371644573 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.145398151210411 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.57

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle