Protein Overview: NOP7

General Information:
Name(s) found:	NOP7 / YGR103W [SGD]
Description(s) found: Found 32 descriptions. SHOW ALL	Component of several different pre-ribosomal particles; forms a complex with Ytm1p and Erb1p that is required for maturation of the large ribosomal subunit; required for exit from G<sub>0</sub> and the initiation of cell proliferation [SGD]
Organism:	Saccharomyces cerevisiae
Length:	605 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA] nucleolus [IDA]
Biological Process:	cell proliferation [IMP] maturation of SSU-rRNA [IMP] ribosomal large subunit biogenesis [IDA ] ribosome biogenesis [RCA] cell cycle [IMP]
Molecular Function:	molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRIKKKNTRG NARNFITRSQ AVRKLQVSLA DFRRLCIFKG IYPREPRNKK KANKGSTAPT  60
   61 TFYYAKDIQY LMHEPVLAKF REHKTFARKL TRALGRGEVS SAKRLEENRD SYTLDHIIKE 120
  121 RYPSFPDAIR DIDDALNMLF LFSNLPSTNQ VSSKIINDAQ KICNQWLAYV AKERLVRKVF 180
  181 VSIKGVYYQA NIKGEEVRWL VPFKFPENIP SDVDFRIMLT FLEFYSTLLH FVLYKLYTDS 240
  241 GLIYPPKLDL KKDKIISGLS SYILESRQED SLLKLDPTEI EEDVKVESLD ASTLKSALNA 300
  301 DEANTDETEK EEEQEKKQEK EQEKEQNEET ELDTFEDNNK NKGDILIQPS KYDSPVASLF 360
  361 SAFVFYVSRE VPIDILEFLI LSCGGNVISE AAMDQIENKK DIDMSKVTHQ IVDRPVLKNK 420
  421 VAGRTYIQPQ WIFDCINKGE LVPANKYLPG EALPPHLSPW GDAIGYDPTA PVEEGEEEES 480
  481 ESESESEDQV EEEDQEVVAG EEDDDDDEEL QAQKELELEA QGIKYSETSE ADKDVNKSKN 540
  541 KKRKVDEEEE EKKLKMIMMS NKQKKLYKKM KYSNAKKEEQ AENLKKKKKQ IAKQKAKLNK 600
  601 LDSKK

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		ARX1 BRX1 BUD20 CIC1 DBP10 DBP9 DRS1 EBP2 ERB1 HAS1 IPI1 IPI3 LSG1 MAK21 MDN1 MRT4 NIP7 NOC2 NOC3 NOG1 NOG2 NOP1 NOP12 NOP15 NOP2 NOP4 NOP7 NSA1 NSA2 NUG1 PUF6 RIX1 RIX7 RLP7 RPF1 RPF2 RPL13A RPL25 RPL27A RPL31A RPL36B RSA4 SDA1 SPB1 SPB4 TIF6 YTM1
View Details	Krogan NJ, et al. (2006)		MSS1 NOP7 NTE1 PDS5 SOP4 STP3 YGR067C YTM1
View Details	Gavin AC, et al. (2002)		AAR2 ADE3 ARX1 ASC1 ATG9 BEM2 BMS1 BRX1 BUD20 CBF5 CIC1 CLU1 CYR1 CYS4 DBP10 DBP2 DBP9 DCP2 DRS1 EBP2 ERB1 FPR4 FUN12 GAR1 GCN1 GLT1 HAS1 HCR1 HDA1 HER1 HIS3 INP2 IPI1 IPI3 IST2 KRE33 KRR1 KTR5 LHP1 LOC1 LSG1 MAK21 MAK5 MDN1 MIS1 MRP7 MRT4 NAP1 NHP2 NIP1 NIP7 NMD3 NOC2 NOC3 NOG1 NOG2 NOP1 NOP12 NOP15 NOP16 NOP2 NOP4 NOP56 NOP6 NOP7 NSA1 NSA2 NUG1 POL2 PRP4 PRT1 PUF6 RAT1 REI1 RIC1 RIX1 RIX7 RLI1 RLP24 RLP7 RPA135 RPA190 RPF1 RPF2 RPG1 RPP2B RPT6 RRP1 RRP12 RSA3 RSA4 RTR1 SDA1 SEC7 SHM1 SKI2 SMB1 SNU114 SNU13 SNU66 SPB1 SPB4 SPT5 SRO9 SSF1 SUA7 SUI1 SUI2 SUI3 SUP45 TIF34 TIF35 TIF4631 TIF4632 TIF5 TIF6 TUB3 URB1 UTP10 UTP20 UTP21 UTP22 UTP6 YGL036W YMR310C YPL009C YTM1
View Details	Ho Y, et al. (2002)		ACO1 AFG2 ALB1 ARX1 BRX1 BUD20 CBF5 CBP2 CIC1 CKA1 CKA2 CKB1 CKB2 COX6 DBP10 DBP7 DNL4 DRS1 DSS4 EBP2 EHD3 ELA1 ENP2 ERB1 EXG1 FAA4 FET4 FIN1 FPR3 FPR4 FYV4 GAR1 GDE1 GLC7 GLC8 GSY1 HAS1 HHF1, HHF2 HIR2 HOT1 HTA1 HTB1 HTB2 HUL5 IMD2 IMD3 IMD4 KAP114 KAP95 KGD1 KRE33 KRI1 KRR1 LHP1 MAK11 MAK16 MAM33 MNP1 MRPL1 MRPS16 MRT4 MSS116 NAP1 NIP7 NMD3 NOC2 NOC3 NOG1 NOP1 NOP12 NOP13 NOP15 NOP16 NOP2 NOP4 NOP56 NOP58 NOP6 NOP7 NSA1 NSA2 NUG1 PDI1 PET127 PHO84 PIB2 POB3 POL2 PRP43 PUF6 PWP1 REG1 RET1 RIX1 RLP7 RPC82 RPF2 RPO31 RRP1 RRP12 RRP14 RRP15 RRP17 RRP5 RRT6 RSM24 RSM25 SCS2 SDS22 SEC4 SFP1 SPB1 SPT16 SRP1 SSF1 THI21 TIF1, TIF2 TIF4631 TIF6 TIS11 TRL1 TSR1 UTP13 UTP22 VMR1 VPS73 WTM2 YBL044W YER077C YPL009C YPT1 YRA1 YTM1
View Details	Qiu et al. (2008)		BRX1 DBP3 DRS1 FPR4 GAR1 KRR1 MAK5 NOP12 NOP15 NOP2 NOP7 NSR1 NUG1 PXR1 SPB4 UTP15 UTP4 UTP6 UTP9 YBL028C

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	ZDS1	Sample 3 - cpn + atp, from june 2005	McCusker D, et al (2007)
View Run	BOI1	Sample boi 1 with ha tag from october 2005	McCusker D, et al (2007)
View Run	MLP2	#32 Asynchronous Prep-No Phosphopeptide enrichment	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	DMC1	NOP7	1	Unpublished Fields Lab Data
View Screen	NOP7	NRP1	1	Unpublished Fields Lab Data
View Screen	NOP7	HOM3	1	Unpublished Fields Lab Data
View Screen	NOP7	CNN1	1	Unpublished Fields Lab Data
View Screen	NOP7	MCM22	1	Unpublished Fields Lab Data
View Screen	NOP7	SRL2	1	Unpublished Fields Lab Data

Microscopy / Localization Data

New Feature: Upload Your Own Microscopy Data

	PROTEIN(S)	PUBLICATION
View Data	NOP7 and NOP56	Huh WK, et al. (2003)
View Data	NOP7	Huh WK, et al. (2003)

Protein Structure Data

[What does the above image mean?]
[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..241]	MSA	2.015945	View MSA. No confident structure predictions are available.
2	View Details	[242..304]	deduced	N/A	Confident ab initio structure predictions are available.
3	View Details	[305..457]	Pfam	12.823909	BRCA1 C Terminus (BRCT) domain No confident structure predictions are available.
4	View Details	[458..605]	PSI-BLAST	3.30103	Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain; Interferon-induced guanylate-binding protein 1 (GBP1), N-terminal domain

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.98

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2