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Protein Overview: RPN8

General Information:
Name(s) found: RPN8 / YOR261C [SGD]
Description(s) found:
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  • gi|6324835|ref|NP_014904.1| Essential, non-ATPase regulatory subunit of the 26S proteasome; has similarity to the human p40 proteasomal subunit and to another S. cerevisiae regulatory subunit, Rpn11p; Rpn8p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|51701933|sp|Q08723.3|RPN8_YEAST RecName: Full=26S proteasome regulatory subunit RPN8 [NCBI NR]
  • pir||S67158 26S proteasome regulatory particle chain RPN8 - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1420589|emb|CAA99483.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • 26S proteasome regulatory subunit RPN8 OS=Saccharomyces cerevisiae GN=RPN8 PE=1 SV=3 [Swiss-Prot]
  • RPN8 26S proteasome regulatory subunit [mips]
  • Essential, non-ATPase regulatory subunit of the 26S proteasome; has similarity to the human p40 proteasomal subunit and to another S. cerevisiae regulatory subunit, Rpn11p [SGD]
  • >Q08723 (Q08723) Chromosome XV reading frame ORF YOR261C [4932.FASTACCERV.txt]
  • Chr XV from 816929-815913, reverse complement [hmr_yeast5_DM3-1_pombe.fasta]
  • Chr XV from 815912-816928, reverse complement [yeastorf3.fasta]
  • Chr XV from 815913-816929, reverse complement [yeastorf4.fasta]
  • RPN8, Chr XV from 815912-816928, reverse complement [yeast_orfs2]
  • RPN8 SGDID:S0005787, Chr XV from 816929-815913, reverse complement, Verified ORF [yeastflysequest.fasta]
  • Essential, non-ATPase regulatory subunit of the 26S proteasome; has similarityl to the human p40 proteasomal subunit and to another S. cerevisiae regulatory subunit, Rpn11p [Saccharomyces cerevisiae]gi|1420589|emb|CAA99483.1| unnamed protein product [Sac [nrdb_11152004_Chlamydomonas]
  • RPN8 SGDID:S000005787, Chr XV from 816929-815913, reverse complement, Verified ORF, "Essential, non-ATPase regulatory subunit of the 26S proteasome; has similarity to the human p40 proteasomal subunit and to another S. cerevisiae regulatory subunit, Rpn11 [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • RPN8 SGDID:S000005787, Chr XV from 816931-815915, reverse complement, Verified ORF, "Essential, non-ATPase regulatory subunit of the 26S proteasome; has similarity to the human p40 proteasomal subunit and to another S. cerevisiae regulatory subunit, Rpn11 [yeast-contam.fasta]
  • Essential, non-ATPase regulatory subunit of the 26S proteasome; has similarity to the human p40 proteasomal subunit and to another S. cerevisiae regulatory subunit, Rpn11p; Rpn8p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • 26S proteasome regulatory subunit RPN8 [nr-271106-contam.fasta]
  • RPN8 SGDID:S000005787, Chr XV from 816931-815915, reverse complement, Verified ORF, "Essential, non-ATPase regulatory subunit of the 26S proteasome; has similarity to the human p40 proteasomal subunit and to another S. cerevisiae regulatory subunit, Rpn11p" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • 26S proteasome regulatory subunit RPN8 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RPN8 PE=1 SV=3 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • RPN8 SGDID:S000005787, Chr XV from 816931-815915, Genome Release 64-1-1, reverse complement, Verified ORF, "Essential, non-ATPase regulatory subunit of the 26S proteasome; has similarity to the human p40 proteasomal subunit and to another S. cerevisiae regulatory subunit, Rpn11p" [yeast-030211-contam.fasta]
  • RPN8 SGDID:S000005787, Chr XV from 816931-815915, Genome Release 64-2-1, reverse complement, Verified ORF, "Essential non-ATPase regulatory subunit of the 26S proteasome; has similarity to the human p40 proteasomal subunit and to another S. cerevisiae regulatory subunit, Rpn11p" [20141208_orf_trans.fasta]
  • YOR261C SGDID:S000005787, Chr XV from 816931-815915, Genome Release 64-1-1, reverse complement, Verified ORF, "Essential, non-ATPase regulatory subunit of the 26S proteasome; has similarity to the human p40 proteasomal subunit and to another S. cerevisiae regulatory subunit, Rpn11p" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 338 amino acids

    Gene Ontology:
    Cellular Component: proteasome regulatory particle, lid subcomplex [IDALink to PubMed article][IPILink to PubMed article]
    Biological Process: ubiquitin-dependent protein catabolic process [TASLink to PubMed articleLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLQHEKVTI APLVLLSALD HYERTQTKEN KRCVGVILGD ANSSTIRVTN SFALPFEEDE  60
   61 KNSDVWFLDH NYIENMNEMC KKINAKEKLI GWYHSGPKLR ASDLKINELF KKYTQNNPLL 120
  121 LIVDVKQQGV GLPTDAYVAI EQVKDDGTST EKTFLHLPCT IEAEEAEEIG VEHLLRDVRD 180
  181 QAAGGLSIRL TNQLKSLKGL QSKLKDVVEY LDKVINKELP INHTILGKLQ DVFNLLPNLG 240
  241 TPDDDEIDVE NHDRINISNN LQKALTVKTN DELMVIYISN LVRSIIAFDD LIENKIQNKK 300
  301 IQEQRVKDKQ SKVSDDSESE SGDKEATAPL IQRKNKKN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CDC39 ECM29 GSG1 NAS6 OSH7 POL4 PRE5 RPN1 RPN10 RPN11 RPN12 RPN13 RPN2 RPN3 RPN5 RPN6 RPN7 RPN8 RPN9 RPT1 RPT2 RPT3 RPT4 RPT5 RPT6 SEC18 SEM1 SLX5 SPG5 SWA2 UBP6 URA3
    View Details (MIPS) Mewes HW, et al. (2004) NAS6 RPN1 RPN10 RPN11 RPN12 RPN2 RPN3 RPN5 RPN6 RPN7 RPN8 RPN9 RPT1 RPT2 RPT3 RPT4 RPT5 RPT6
    View Details Krogan NJ, et al. (2006) CSI1 CSN9 ERV46 FPR2 HUL5 IQG1 MOT1 MPT5 NAS6 NMD3 NPT1 PCI8 PEP1 PST1 PUS9 RPN1 RPN10 RPN11 RPN12 RPN13 RPN14 RPN2 RPN5 RPN6 RPN7 RPN8 RPN9 RPT1 RPT2 RPT3 RPT4 RPT5 RPT6 RRI1 RRI2 SEC18 SEM1 SKP1 SPG5 SPO77 SQT1 SWA2 TCB2 TIP41 TOD6 TOR2 TSR4 UBP6 YEN1 YKL027W YMR258C YNL022C YPR003C YPT52
    View Details Gavin AC, et al. (2006) ECM29 RPN1 RPN10 RPN11 RPN12 RPN13 RPN5 RPN6 RPN7 RPN8 RPN9 RPT1
    View Details Gavin AC, et al. (2002) ACC1 BDF2 BLM10 CCT8 CDC55 CDC6 CKB1 CLU1 CPA2 DNA2 DYN1 ECM29 ECM5 FDH1 GCN20 GFA1 GLY1 GUS1 HAT1 HAT2 HHF1, HHF2 HIF1 HSM3 ICL1 ILV1 IML1 KAP123 KAP95 KRE33 LIP2 LYS12 MAC1 MDN1 MEC1 MIS1 MLH2 MPH1 MRPL3 MRPS28 MSB1 MSH2 MSH6 NAS6 NIP1 NMD5 PFK1 PGK1 PRE1 PRE10 PRE2 PRE3 PRE4 PRE5 PRE6 PRE7 PRE8 PRE9 PRO1 PRT1 PSA1 PSD2 PSE1 PSH1 PUP3 RAD23 RAD34 RAD4 RAD52 RFA1 RFA2 RGR1 RPA135 RPB2 RPC40 RPG1 RPN10 RPN11 RPN12 RPN13 RPN3 RPN5 RPN6 RPN7 RPN8 RPN9 RPT1 RPT2 RPT3 RPT4 RPT5 RPT6 RSC3 SAM1 SCL1 SEC27 SMC3 SRO7 SSL1 TCB1 TEL1 TFA1 TFB1 TFB4 TIF1, TIF2 TSA1 TSC11 TUB3 UBP6 URA7 USO1 UTP20 VAS1 VTH2 YFL006W YFR006W YOL098C YPR077C
    View Details Ho Y, et al. (2002) AAC1 AAC3 AHA1 APA1 ARC15 ARC18 ARC19 ARC35 ARC40 ARP2 ARP3 ATP3 CDC53 CIA1 CPR6 DOG1 EMP24 FET3 FUS3 GAR1 GFA1 GUF1 HOG1 HRT1 IDH1 IDH2 KGD1 KIN28 KRE6 LHS1 LSM2 LSM8 MDH1 MDN1 MDY2 MET18 MKT1 NAS6 NMD5 PET10 PHO84 PPH21 PPH22 PRB1 PST2 PUF3 QCR2 RAD3 RCK1 REP1 RIX7 ROD1 RPN1 RPN10 RPN11 RPN12 RPN13 RPN14 RPN3 RPN5 RPN6 RPN7 RPN8 RPN9 RPT1 RPT2 RPT3 RPT4 RPT5 RRP42 RTT101 RVB1 SDH2 SEC27 SMB1 SNF1 SPS1 STI1 TFB3 TFP1 TIF6 UBC12 UBP9 VMA8 VPS74 YBR184W YGL117W YHR033W
    View Details Qiu et al. (2008) NAS6 PRE10 PRE4 PRE6 RPN1 RPN10 RPN11 RPN12 RPN13 RPN2 RPN3 RPN5 RPN6 RPN7 RPN8 RPN9 RPT1 RPT2 RPT3 RPT4 RPT5 RPT6

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)
    View Run MLP2 #06 Alpha Factor Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen SNA4 RPN8 2 Unpublished Fields Lab Data
    View Screen RPN11 RPN8 2 Unpublished Fields Lab Data
    View Screen KRI1 RPN8 2 Unpublished Fields Lab Data
    View Screen RPN5 RPN8 1 Unpublished Fields Lab Data
    View Screen RPN11 RPN8 1 Uetz P, et al. (2000)
    View Screen TOS2 RPN8 1 Unpublished Fields Lab Data
    View Screen RPN8 EDC1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data RPN8 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..125] Pfam 46.113509 Mov34/MPN/PAD-1 family No confident structure predictions are available.
    2 View Details [126..338] MSA 3.071979 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.74

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle