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Protein Overview: PUS9

General Information:
Name(s) found: PUS9 / YDL036C [SGD]
Description(s) found:
Found 28 descriptions.
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  • Mitochondrial tRNA:pseudouridine synthase, catalyzes the formation of pseudouridine at position 32 in mitochondrial tRNAs; contains an N-terminal mitochondrial targeting sequence [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 462 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    mitochondrion [IMPLink to PubMed article][ISSLink to PubMed article]
    Biological Process: tRNA pseudouridine synthesis [IDALink to PubMed article][IMPLink to PubMed article]
    Molecular Function: RNA binding [IEA]
    pseudouridine synthase activity [IDA][IEA][IMP]
    isomerase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQRNNRLRNL FTVPVIMARQ LKRNALSAGL AFAGNATSNE FDEHLQNEVE REREIQKKKK  60
   61 IKRTQSKKSP DLINKSTFQS RTIGSKKEKH RQLDPEYEIV IDGPLRKIKP YHFTYRTFCK 120
  121 ERWRDKKLVD VFISEFRDRE SEYYKRTIEN GDVHINDETA DLSTVIRNGD LITHQVHRHE 180
  181 PPVTSRPIKV IFEDDNIMVI DKPSGIPVHP TGRYRFNTIT KMLQNNLGFV VNPCNRLDRL 240
  241 TSGLMFLAKT PKGADNIGDQ LKAREVTKEY VAKVVGEFPE TEVIVEKPLK LIEPRLALNA 300
  301 VCQMDEKGAK HAKTVFNRIS YDGKTSIVKC KPLTGRSHQI RVHLQYLGHP IANDPIYSND 360
  361 EVWGNNLGKG GQADFDIVIT KLDEIGKRKP AKSWFHSNGG YGEVLRQEKC SICESDLYTD 420
  421 PGPNDLDLWL HAYLYESTET EEGTEKKKWC YKTEYPEWAL RR

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) CSI1 CSN9 ERV46 FPR2 HUL5 IQG1 MOT1 MPT5 NAS6 NMD3 NPT1 PCI8 PEP1 PST1 PUS9 RPN1 RPN10 RPN11 RPN12 RPN13 RPN14 RPN2 RPN5 RPN6 RPN7 RPN8 RPN9 RPT1 RPT2 RPT3 RPT4 RPT5 RPT6 RRI1 RRI2 SEC18 SEM1 SKP1 SPG5 SPO77 SQT1 SWA2 TCB2 TIP41 TOD6 TOR2 TSR4 UBP6 YEN1 YKL027W YMR258C YNL022C YPR003C YPT52

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data PUS9 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..127] PSI-BLAST 22.522879 Ribosomal protein S4
    2 View Details [128..193] PSI-BLAST 36.69897 Ribosomal small subunit pseudouridine 516 synthase RsuA; Pseudouridine synthase RsuA N-terminal domain
    3 View Details [194..380] PSI-BLAST 36.69897 Ribosomal small subunit pseudouridine 516 synthase RsuA; Pseudouridine synthase RsuA N-terminal domain
    4 View Details [381..462] MSA 1.260994 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • pseudouridine synthase activity
    		•  5.19957135839682 bayes_pls_golite062009
  • intramolecular transferase activity
    		•  3.78688422405974 bayes_pls_golite062009
  • isomerase activity
    		•  2.91720316078381 bayes_pls_golite062009
  • catalytic activity
    		•  2.02180970970004 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.21173188039059 bayes_pls_golite062009
  • DNA binding
    		•  0.950713703876672 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.909704702595901 bayes_pls_golite062009
  • binding
    		•  0.730744558777463 bayes_pls_golite062009
  • RNA binding
    		•  0.706879359688019 bayes_pls_golite062009
  • transferase activity
    		•  0.237728328252954 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle