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Protein Overview: MPT5

General Information:
Name(s) found: MPT5 / YGL178W [SGD]
Description(s) found:
Found 23 descriptions.
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  • Member of the Puf family of RNA-binding proteins; binds to mRNAs encoding chromatin modifiers and spindle pole body components; involved in longevity, maintenance of cell wall integrity, and sensitivity to and recovery from pheromone arrest [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 859 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: protein targeting [IMPLink to PubMed article]
    loss of chromatin silencing involved in replicative cell aging [IEPLink to PubMed article][IGILink to PubMed article][IMPLink to PubMed article]
    cellular cell wall organization [IMPLink to PubMed article]
    replicative cell aging [IMPLink to PubMed article]
    nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [IGILink to PubMed article]
    re-entry into mitotic cell cycle after pheromone arrest [IMPLink to PubMed article]
    Molecular Function: mRNA binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MINNEPFPSA DSASILTTST SNNSLMSYNH QPQLSINSVQ SLLEPVTPPP LGQMNNKRNH  60
   61 QKAHSLDLSG FNQFISSTQS PLALMNNTST SNSANSFSPN PNAASNSTGL SASMANPPAI 120
  121 LPLINEFDLE MDGPRRKSSH DFTVVAPSNS GVNTSSLIME TPSSSVTPAA SLRNFSNSNN 180
  181 AASKCGVDNS SFGLSSSTSS SMVEISALPL RDLDYIKLAT DQFGCRFLQK KLETPSESNM 240
  241 VRDLMYEQIK PFFLDLILDP FGNYLVQKLC DYLTAEQKTL LIQTIYPNVF QISINQYGTR 300
  301 SLQKIIDTVD NEVQIDLIIK GFSQEFTSIE QVVTLINDLN GNHVIQKCIF KFSPSKFGFI 360
  361 IDAIVEQNNI ITISTHKHGC CVLQKLLSVC TLQQIFKISV KIVQFLPGLI NDQFGNYIIQ 420
  421 FLLDIKELDF YLLAELFNRL SNELCQLSCL KFSSNVVEKF IKKLFRIITG FIVNNNGGAS 480
  481 QRTAVASDDV INASMNILLT TIDIFTVNLN VLIRDNFGNY ALQTLLDVKN YSPLLAYNKN 540
  541 SNAIGQNSSS TLNYGNFCND FSLKIGNLIV LTKELLPSIK TTSYAKKIKL KVKAYAEATG 600
  601 IPFTDISPQV TAMSHNNLQT INNENKNPHN KNSHNHNHNH NHNHAHNNNN NNNQKSHTRH 660
  661 FSLPANAYHR RSNSSVTNNF SNQYAQDQKI HSPQQIMNFN QNAYPSMGAP SFNSQTNPPL 720
  721 VSHNSLQNFD NRQFANLMAH PNSAAPIHSF SSSNITNVNP NVSRGFKQPG FMMNETDKIN 780
  781 ANHFSPYSNA NSQNFNESFV PRMQYQTEGA NWDSSLSMKS QHIGQGPYNQ VNMSRNASIS 840
  841 NMPAMNTART SDELQFTLP

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) CSI1 CSN9 ERV46 FPR2 HUL5 IQG1 MOT1 MPT5 NAS6 NMD3 NPT1 PCI8 PEP1 PST1 PUS9 RPN1 RPN10 RPN11 RPN12 RPN13 RPN14 RPN2 RPN5 RPN6 RPN7 RPN8 RPN9 RPT1 RPT2 RPT3 RPT4 RPT5 RPT6 RRI1 RRI2 SEC18 SEM1 SKP1 SPG5 SPO77 SQT1 SWA2 TCB2 TIP41 TOD6 TOR2 TSR4 UBP6 YEN1 YKL027W YMR258C YNL022C YPR003C YPT52

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data MPT5 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..181] MSA 22.163997 View MSA. No confident structure predictions are available.
    2 View Details [182..328] PSI-BLAST 465.0 Pumilio 1
    3 View Details [329..429] PSI-BLAST 465.0 Pumilio 1
    4 View Details [430..628] PSI-BLAST 465.0 Pumilio 1
    5 View Details [629..859] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle