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Protein Overview: HOG1

General Information:
Name(s) found: HOG1 / YLR113W [SGD]
Description(s) found:
Found 24 descriptions.
SHOW ALL
  • Mitogen-activated protein kinase involved in osmoregulation via three independent osmosensors; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 435 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed articleLink to PubMed article]
    Biological Process: negative regulation of transcription from RNA polymerase II promoter by pheromones [IEPLink to PubMed article]
    osmosensory signaling pathway [IMPLink to PubMed article]
    response to arsenic [IGILink to PubMed article][IMPLink to PubMed article]
    protein amino acid phosphorylation [IDALink to PubMed article]
    positive regulation of transcription from RNA polymerase II promoter [IDALink to PubMed article]
    hyperosmotic response [IMPLink to PubMed article]
    Molecular Function: MAP kinase activity [IDALink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTNEEFIRT QIFGTVFEIT NRYNDLNPVG MGAFGLVCSA TDTLTSQPVA IKKIMKPFST  60
   61 AVLAKRTYRE LKLLKHLRHE NLICLQDIFL SPLEDIYFVT ELQGTDLHRL LQTRPLEKQF 120
  121 VQYFLYQILR GLKYVHSAGV IHRDLKPSNI LINENCDLKI CDFGLARIQD PQMTGYVSTR 180
  181 YYRAPEIMLT WQKYDVEVDI WSAGCIFAEM IEGKPLFPGK DHVHQFSIIT DLLGSPPKDV 240
  241 INTICSENTL KFVTSLPHRD PIPFSERFKT VEPDAVDLLE KMLVFDPKKR ITAADALAHP 300
  301 YSAPYHDPTD EPVADAKFDW HFNDADLPVD TWRVMMYSEI LDFHKIGGSD GQIDISATFD 360
  361 DQVAAATAAA AQAQAQAQAQ VQLNMAAHSH NGAGTTGNDH SDIAGGNKVS DHVAANDTIT 420
  421 DYGNQAIQYA NEFQQ

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) HOG1 RCK2
    View Details Krogan NJ, et al. (2006) HOG1 RCK2
    View Details Ho Y, et al. (2002) EAF1 FET4 FUS3 HOG1 IDH2 RCK1 RCK2 ROD1 RPN8 SNF1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data HOG1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..102]
    [319..382]    		 PSI-BLAST 1185.0 MAP kinase p38
    2 View Details [103..318] PSI-BLAST 1185.0 MAP kinase p38
    3 View Details [383..435] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • acetylcholine receptor activator activity
    		•  5.9159846946654 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  5.68265749805481 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.49988294224815 bayes_pls_golite062009
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • kinase activity
    		•  5.3287080791198 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.96052051118534 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  4.62392503670521 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transferase activity
    		•  3.97138602499442 bayes_pls_golite062009
  • structural molecule activity
    		•  3.82327979736517 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  3.41480681854114 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  3.40140621607334 bayes_pls_golite062009
  • MAP kinase 2 activity
    		•  3.27009208121248 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  2.8153155526437 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  2.79505438761262 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  2.59526003830791 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.52531786618214 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.46424348876434 bayes_pls_golite062009
  • signal transducer activity
    		•  2.40586892801446 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.40586892801446 bayes_pls_golite062009
  • receptor activity
    		•  2.39311927684508 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.37122853419919 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase activity
    		•  2.30873410607588 bayes_pls_golite062009
  • transforming growth factor beta receptor activity
    		•  2.30873410607588 bayes_pls_golite062009
  • histone kinase activity (H3-S10 specific)
    		•  2.30449166929476 bayes_pls_golite062009
  • protein binding
    		•  2.276111749106 bayes_pls_golite062009
  • tubulin binding
    		•  2.18641675163967 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.12615078788254 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  2.10379226653669 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  1.94085498993561 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  1.9016235206634 bayes_pls_golite062009
  • microtubule binding
    		•  1.88110801192607 bayes_pls_golite062009
  • actin binding
    		•  1.87817875565699 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.81249386965144 bayes_pls_golite062009
  • telethonin binding
    		•  1.75733591474207 bayes_pls_golite062009
  • transforming growth factor beta receptor activity, type I
    		•  1.74645334586495 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  1.74206248731815 bayes_pls_golite062009
  • activin binding
    		•  1.69795678545106 bayes_pls_golite062009
  • fibroblast growth factor 1 binding
    		•  1.66976264488423 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • activin receptor activity
    		•  1.64506335968643 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • insulin receptor substrate binding
    		•  1.62657794525303 bayes_pls_golite062009
  • JUN kinase kinase kinase activity
    		•  1.60259443694567 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.56748951434625 bayes_pls_golite062009
  • growth factor binding
    		•  1.53863828216563 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.46547714006072 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  1.42275431028856 bayes_pls_golite062009
  • DNA binding
    		•  1.35333135345112 bayes_pls_golite062009
  • ErbB-3 class receptor binding
    		•  1.34841233233438 bayes_pls_golite062009
  • ErbB-2 class receptor binding
    		•  1.33825339298024 bayes_pls_golite062009
  • kinase binding
    		•  1.26086833316556 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  1.2266791546014 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • transcription elongation regulator activity
    		•  1.16995153203536 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.14496167267281 bayes_pls_golite062009
  • transporter activity
    		•  1.11833481501707 bayes_pls_golite062009
  • non-membrane spanning protein tyrosine kinase activity
    		•  1.11664317075762 bayes_pls_golite062009
  • transcription factor activity
    		•  1.10928254946881 bayes_pls_golite062009
  • protein kinase binding
    		•  1.06030596516506 bayes_pls_golite062009
  • cation channel activity
    		•  1.04999722123563 bayes_pls_golite062009
  • type II transforming growth factor beta receptor binding
    		•  1.03605423743048 bayes_pls_golite062009
  • SMAD binding
    		•  1.02108562119195 bayes_pls_golite062009
  • transcription activator activity
    		•  0.997272622653026 bayes_pls_golite062009
  • PTB domain binding
    		•  0.9900774724568 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.97575992765505 bayes_pls_golite062009
  • alpha-actinin binding
    		•  0.877087652539674 bayes_pls_golite062009
  • insulin-like growth factor receptor binding
    		•  0.872782211382796 bayes_pls_golite062009
  • fibroblast growth factor binding
    		•  0.870666814073948 bayes_pls_golite062009
  • activin receptor activity, type I
    		•  0.82317428935631 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.81943579965027 bayes_pls_golite062009
  • actin filament binding
    		•  0.794152600084 bayes_pls_golite062009
  • fibroblast growth factor receptor activity
    		•  0.75189004129952 bayes_pls_golite062009
  • receptor serine/threonine kinase binding
    		•  0.728917900114111 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.705905455086486 bayes_pls_golite062009
  • transforming growth factor beta receptor binding
    		•  0.705634826374884 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase binding
    		•  0.705634826374884 bayes_pls_golite062009
  • hormone receptor binding
    		•  0.705067960165986 bayes_pls_golite062009
  • beta-catenin binding
    		•  0.693246095477001 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.612883428421652 bayes_pls_golite062009
  • JUN kinase kinase kinase kinase activity
    		•  0.546647574638943 bayes_pls_golite062009
  • cyclin-dependent protein kinase activating kinase activity
    		•  0.529121666062889 bayes_pls_golite062009
  • steroid hormone receptor binding
    		•  0.505233004492768 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • enzyme binding
    		•  0.46284745266176 bayes_pls_golite062009
  • transforming growth factor beta binding
    		•  0.435457844706269 bayes_pls_golite062009
  • protein kinase C activity
    		•  0.41587987561486 bayes_pls_golite062009
  • cyclin-dependent protein kinase regulator activity
    		•  0.406297251827056 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.401250804041384 bayes_pls_golite062009
  • structural constituent of muscle
    		•  0.399773397398032 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • JUN kinase kinase activity
    		•  0.332372116912461 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.318153468064373 bayes_pls_golite062009
  • channel activity
    		•  0.287189255116606 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  0.287189255116606 bayes_pls_golite062009
  • insulin receptor binding
    		•  0.266450215230107 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  0.261869836686301 bayes_pls_golite062009
  • RNA binding
    		•  0.245748631571068 bayes_pls_golite062009
  • ion channel activity
    		•  0.241519346930618 bayes_pls_golite062009
  • nuclear hormone receptor binding
    		•  0.240883589532225 bayes_pls_golite062009
  • protein complex binding
    		•  0.239339759110451 bayes_pls_golite062009
  • insulin receptor activity
    		•  0.237134032032089 bayes_pls_golite062009
  • SH2 domain binding
    		•  0.226760162354251 bayes_pls_golite062009
  • ligase activity, forming carbon-oxygen bonds
    		•  0.149958560815481 bayes_pls_golite062009
  • ligase activity, forming aminoacyl-tRNA and related compounds
    		•  0.149958560815481 bayes_pls_golite062009
  • aminoacyl-tRNA ligase activity
    		•  0.14842991990838 bayes_pls_golite062009
  • peptide binding
    		•  0.118578378753757 bayes_pls_golite062009
  • brain-derived neurotrophic factor binding
    		•  0.0794053647730006 bayes_pls_golite062009
  • nitric-oxide synthase regulator activity
    		•  0.00407218246327123 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0040394359628233 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle