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Protein Overview: RCK2

General Information:
Name(s) found: RCK2 / YLR248W [SGD]
Description(s) found:
Found 17 descriptions.
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  • Protein kinase involved in the response to oxidative and osmotic stress; identified as suppressor of S. pombe cell cycle checkpoint mutations [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 610 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: osmosensory signaling pathway [IGILink to PubMed article][IMPLink to PubMed article][IPILink to PubMed article]
    regulation of meiosis [IGILink to PubMed article][IMPLink to PubMed article]
    protein amino acid phosphorylation [IDALink to PubMed article][ISSLink to PubMed article]
    Molecular Function: protein serine/threonine kinase activity [IDALink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLKIKALFSK KKPDQADLSQ ESKKPFKGKT RSSGTNNKDV SQITSSPKKS FQDKNIVQYP  60
   61 SVVADDHHMK SLTDELVTTI DSDSSPSDNI TTENVETVTS VPAIDVHESS EGQLSSDPLI 120
  121 SDESLSEQSE IISDIQDDST DDDNMEDEIP EKSFLEQKEL IGYKLINKIG EGAFSKVFRA 180
  181 IPAKNSSNEF LTKNYKAVAI KVIKKADLSS INGDHRKKDK GKDSTKTSSR DQVLKEVALH 240
  241 KTVSAGCSQI VAFIDFQETD SYYYIIQELL TGGEIFGEIV RLTYFSEDLS RHVIKQLALA 300
  301 VKHMHSLGVV HRDIKPENLL FEPIEFTRSI KPKLRKSDDP QTKADEGIFT PGVGGGGIGI 360
  361 VKLADFGLSK QIFSKNTKTP CGTVGYTAPE VVKDEHYSMK VDMWGIGCVL YTMLCGFPPF 420
  421 YDEKIDTLTE KISRGEYTFL KPWWDEISAG AKNAVAKLLE LEPSKRYDID QFLDDPWLNT 480
  481 FDCLPKEGES SQKKAGTSER RHPHKKQFQL FQRDSSLLFS PAAVAMRDAF DIGNAVKRTE 540
  541 EDRMGTRGGL GSLAEDEELE DSYSGAQGDE QLEQNMFQLT LDTSTILQRR KKVQENDVGP 600
  601 TIPISATIRE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) HOG1 RCK2
    View Details Krogan NJ, et al. (2006) HOG1 RCK2
    View Details Ho Y, et al. (2002) EAF1 FET4 HOG1 RCK2 VPS41

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data RCK2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..120] deduced N/A No confident structure predictions are available.
    2 View Details [121..272] PSI-BLAST 519.855515 Calmodulin-dependent protein kinase
    3 View Details [273..532] PSI-BLAST 519.855515 Calmodulin-dependent protein kinase
    4 View Details [533..610] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle