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Protein Overview: STO1

General Information:
Name(s) found: STO1 / YMR125W [SGD]
Description(s) found:
Found 22 descriptions.
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  • Large subunit of the nuclear mRNA cap-binding protein complex, interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80 [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 861 amino acids

    Gene Ontology:
    Cellular Component: commitment complex [IPILink to PubMed article]
    nuclear cap binding complex [IDALink to PubMed article]
    Biological Process: nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [IDALink to PubMed article][IPILink to PubMed article]
    telomere maintenance [IMPLink to PubMed articleLink to PubMed article]
    nuclear mRNA splicing, via spliceosome [IPILink to PubMed article]
    Molecular Function: mRNA binding [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFNRKRRGDF DEDENYRDFR PRMPKRQRIP PVVQLCKEMM PDIRTIGESV KAFEDDIKFL  60
   61 SEAIMNEYGH EDYFNNALLS TLNAVVVEQP QKQAAIALLT MVVNSKNNVA GKSIINYFFE 120
  121 ELQKWCKQTY NDEFKSTSNE TGPWNKIKLI LRFLSILSPM FLVDELINIY KSLFELSIEL 180
  181 NNLDPGNRVP LSEAIYTNTL LNIPYLFFFN RNNDGLRTKV EELLAYVEQN YLVKTTDINL 240
  241 LREYNGEPPY EMVELVRVVL PNVKKALINN LEQLNELFPD WNHLLTPQTG DEGFNDALTL 300
  301 PSVDDLKSFV RLNKNFGSVD SMWKTPRYAF HVYLPNSAGN FETVVPISTY AGQLFNDIII 360
  361 DLVESLEFNR KEVARQVITL DLFFKAGIFT EPGESIAQLI ATYEENPLAP TFKIEDLAIE 420
  421 TILGLIFKLP SVSQPFAYFY TLLVDICQNS PKAIAPVFGR AFRFFYSHLD SLDFELKLRY 480
  481 LDWFSIQMSN FNFSWKWNEW EDDSIKFGKY FYNPKVNFAK NLIQKELRLT SNFSEVEDSL 540
  541 PQEFTKYLDT SYIPRDQLIN YYQSLFTGYT VEEDSVRKND LYFRQEGVPM ENTVRKILDY 600
  601 THKANNSREV TELESILGEL KNEYGSIISD FNRFVIILLV QAVTDSGSRS LSHANKYIND 660
  661 LKEDLKTIFA KIELDIETKE YIIIEAVLTF WNANPQTGFL VADAFKYAGL LTSRTIFTFI 720
  721 FNETGLKNNG LIEATAIEAV FRNLSQQISE ENESGNNFEF VFERLCTIAN STIDLLDVNA 780
  781 DEDIEIPKVN GEMDIDDIED DKLDLKWKYF TVIGFIKSIL RRYSHEYREL ADKFIANIDN 840
  841 AIPHESTRRT ISNWIQETKE V

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) BRR2 CBC2 CDC33 CLF1 CSN12 CUS1 DIB1 GBP2 HSH155 KAP95 KEM1 LEA1 LUC7 MUD1 NAB3 NAM8 NPL3 NRD1 PRP11 PRP19 PRP21 PRP39 PRP40 PRP42 PRP43 PRP46 PRP8 PRP9 RSE1 SBP1 SMB1 SMD1 SMD2 SMD3 SNP1 SNT309 SNU114 SNU56 SNU71 SPP382 SRO9 SRP1 STO1 TIF4631 TIF4632 YHC1 YRA2
    View Details (MIPS) Mewes HW, et al. (2004) AAR2 BRR1 BRR2 CBC2 CDC40 CWC15 CWC2 CWC22 CWC23 DHR2 LSM4 MAK5 MUD2 PRP16 PRP18 PRP2 PRP22 PRP24 PRP28 PRP31 PRP38 PRP39 PRP4 PRP40 PRP43 PRP5 PRP6 PRP8 SLU7 SMD1 SMD3 SME1 SNP1 SPP2 SPP381 STO1 YHC1
    View Details Krogan NJ, et al. (2006) CBC2 KAP95 NUP1 NUP2 NUP60 OGG1 PCT1 RAD53 SRP1 STO1 ULP1 URB2 YRA2
    View Details Gavin AC, et al. (2006) MTR4 NAB3 NRD1 SEN1 STO1
    View Details Gavin AC, et al. (2002) AAR2 ABF2 ADE5,7 AIR2 ASC1 BRR1 BUD31 BUR2 CBC2 CBF5 CDC33 CDC40 CEF1 CKA1 CKA2 CKB1 CKB2 CLF1 CSN12 CTI6 CUS1 CWC2 CWC22 CWC23 DBP2 DEP1 DHH1 DIB1 DOT6 EAF3 ECM16 ECM2 GCN2 HCA4 HEK2 HHF1, HHF2 HRT1 HSH155 HSH49 HTA1 HTA2 IMG1 IML1 IOC3 ISW1 ISW2 ISY1 ITC1 KAP95 LEA1 LHP1 LIN1 LSM1 LSM2 LSM4 LSM5 LSM6 LSM7 LUC7 MED4 MIS1 MOT1 MRP7 MRPL28 MRPL3 MRPL35 MRPL38 MRPL4 MRPL8 MRPS5 MSH4 MSL1 MUD1 NAB3 NAB6 NAM7 NAM8 NHP10 NPL3 NPL6 NRD1 NRP1 NUP60 PAT1 PHO23 POL2 PRP11 PRP18 PRP19 PRP2 PRP21 PRP22 PRP24 PRP28 PRP3 PRP31 PRP38 PRP39 PRP4 PRP40 PRP42 PRP43 PRP45 PRP46 PRP6 PRP8 PRP9 PUB1 PUS7 RBG1 RCO1 REB1 RFA1 RFX1 RNR2 ROM2 RPC34 RPC40 RPD3 RPO31 RSC2 RSC3 RSC58 RSC8 RSE1 RVB2 RXT2 RXT3 SAP30 SBP1 SCP160 SDS3 SEN1 SFH1 SGN1 SGV1 SIN3 SLU7 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNF2 SNP1 SNT309 SNU114 SNU23 SNU56 SNU66 SNU71 SPP381 SPP382 SRB2 SRO9 SRP1 STH1 STM1 STO1 SUI3 SWI1 SYF1 TAF1 TFC7 THO2 TIF1, TIF2 TIF4631 TIF4632 TOP1 TOS4 TUP1 UME1 UME6 UTP20 UTP21 VPS1 YBR090C-A, NHP6B YEF3 YML6 YMR310C YRA2
    View Details Ho Y, et al. (2002) DIS3 EAF3 FIP1 HAS1 HPR1 KAP95 MES1 MFT1 NAM8 NOP6 NUP1 NUP2 NUP60 PAP1 PCT1 REB1 RNT1 RRP4 RRP43 RRP6 RTT103 SIF2 SIN3 SNU56 SRP1 STO1 THO2 TRA1 UME1 YPR090W
    View Details Qiu et al. (2008) AAR2 BRR1 BRR2 BUD31 CBC2 CDC40 CEF1 CLF1 CUS1 CWC15 CWC2 CWC22 CWC23 CWC25 DHR2 DIB1 ECM2 HSH155 ISY1 LSM2 LSM4 LSM5 LUC7 MAK5 MSL1 MUD1 MUD2 NAM8 PRP11 PRP16 PRP18 PRP19 PRP2 PRP21 PRP22 PRP24 PRP28 PRP3 PRP31 PRP38 PRP39 PRP4 PRP40 PRP42 PRP43 PRP45 PRP5 PRP6 PRP8 PRP9 RSE1 SLU7 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNP1 SNT309 SNU114 SNU23 SNU56 SNU66 SNU71 SPP2 SPP381 SPP382 STO1 SYF1 SYF2 YHC1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CWC25 No Comments Hazbun TR, et al. (2003)
    View Run PAN1 No Comments Toshima J, et al (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen YLR132C STO1 1 Hazbun TR, et al. (2003)
    View Screen PEX13 STO1 1 Unpublished Fields Lab Data
    View Screen UBC7 STO1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data STO1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..231]
    [259..320]    		 PSI-BLAST 1136.9897 CBP80, 80KDa nuclear cap-binding protein
    2 View Details [232..258]
    [321..462]    		 PSI-BLAST 1136.9897 CBP80, 80KDa nuclear cap-binding protein
    3 View Details [463..555] PSI-BLAST 1136.9897 CBP80, 80KDa nuclear cap-binding protein
    4 View Details [556..861] PSI-BLAST 1136.9897 CBP80, 80KDa nuclear cap-binding protein

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • RNA cap binding
    		•  6.31996430626206 bayes_pls_golite062009
  • RNA binding
    		•  4.20683443264388 bayes_pls_golite062009
  • binding
    		•  3.0667965351474 bayes_pls_golite062009
  • structural molecule activity
    		•  2.87774614675757 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.74745843355294 bayes_pls_golite062009
  • mRNA binding
    		•  2.49094746544717 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.16673352512615 bayes_pls_golite062009
  • DNA binding
    		•  1.95242774903625 bayes_pls_golite062009
  • protein binding
    		•  1.73688475473996 bayes_pls_golite062009
  • transcription factor activity
    		•  1.20660383756339 bayes_pls_golite062009
  • translation regulator activity
    		•  1.02418717576405 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  1.00890624159335 bayes_pls_golite062009
  • translation initiation factor activity
    		•  0.83079633551839 bayes_pls_golite062009
  • hydrolase activity
    		•  0.42501390959416 bayes_pls_golite062009
  • transcription activator activity
    		•  0.160275383613705 bayes_pls_golite062009
  • transcription factor binding
    		•  0.0221966060394205 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.92

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle