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Protein Overview: OGG1

General Information:
Name(s) found: OGG1 / YML060W [SGD]
Description(s) found:
Found 27 descriptions.
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  • Mitochondrial glycosylase/lyase that specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA, contributes to UVA resistance [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 376 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed article]
    Biological Process: DNA repair [IMPLink to PubMed article]
    base-excision repair, AP site formation [IDALink to PubMed article]
    telomere maintenance [IMPLink to PubMed article]
    Molecular Function: oxidized purine base lesion DNA N-glycosylase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSYKFGKLAI NKSELCLANV LQAGQSFRWI WDEKLNQYST TMKIGQQEKY SVVILRQDEE  60
   61 NEILEFVAVG DCGNQDALKT HLMKYFRLDV SLKHLFDNVW IPSDKAFAKL SPQGIRILAQ 120
  121 EPWETLISFI CSSNNNISRI TRMCNSLCSN FGNLITTIDG VAYHSFPTSE ELTSRATEAK 180
  181 LRELGFGYRA KYIIETARKL VNDKAEANIT SDTTYLQSIC KDAQYEDVRE HLMSYNGVGP 240
  241 KVADCVCLMG LHMDGIVPVD VHVSRIAKRD YQISANKNHL KELRTKYNAL PISRKKINLE 300
  301 LDHIRLMLFK KWGSYAGWAQ GVLFSKEIGG TSGSTTTGTI KKRKWDMIKE TEAIVTKQMK 360
  361 LKVELSDLHI KEAKID

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) CBC2 KAP95 NUP1 NUP2 NUP60 OGG1 PCT1 RAD53 SRP1 STO1 ULP1 URB2 YRA2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ASF1 3829 - low filter Green EM, et al (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data OGG1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..10]
    [30..82]
    [154..164]    		 PSI-BLAST 564.38764 8-oxoguanine glycosylase
    2 View Details [11..29]
    [83..118]
    [321..376]    		 PSI-BLAST 564.38764 8-oxoguanine glycosylase
    3 View Details [119..153]
    [165..320]    		 PSI-BLAST 564.38764 8-oxoguanine glycosylase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA N-glycosylase activity
    		•  4.8124964619976 bayes_pls_golite062009
  • hydrolase activity, hydrolyzing N-glycosyl compounds
    		•  4.26870112679392 bayes_pls_golite062009
  • DNA-(apurinic or apyrimidinic site) lyase activity
    		•  3.71152530486175 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  3.62178291472984 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.86205700023542 bayes_pls_golite062009
  • DNA binding
    		•  2.5120791469793 bayes_pls_golite062009
  • oxidized base lesion DNA N-glycosylase activity
    		•  2.49872706126491 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.39934080314995 bayes_pls_golite062009
  • hydrolase activity
    		•  2.39042189031819 bayes_pls_golite062009
  • 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
    		•  2.21048599823382 bayes_pls_golite062009
  • hydrolase activity, acting on glycosyl bonds
    		•  2.18053745735048 bayes_pls_golite062009
  • binding
    		•  2.13602784299456 bayes_pls_golite062009
  • catalytic activity
    		•  2.13345932727422 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.08009333103564 bayes_pls_golite062009
  • damaged DNA binding
    		•  2.00388798014411 bayes_pls_golite062009
  • alkylbase DNA N-glycosylase activity
    		•  1.5832578018127 bayes_pls_golite062009
  • oxidized purine base lesion DNA N-glycosylase activity
    		•  1.32985950765371 bayes_pls_golite062009
  • oxidized pyrimidine base lesion DNA N-glycosylase activity
    		•  1.2016453685638 bayes_pls_golite062009
  • DNA-3-methyladenine glycosylase I activity
    		•  1.06383943982125 bayes_pls_golite062009
  • transcription factor activity
    		•  0.91701565472544 bayes_pls_golite062009
  • transcription factor binding
    		•  0.88531282989512 bayes_pls_golite062009
  • uracil DNA N-glycosylase activity
    		•  0.879508131574476 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.85419760398899 bayes_pls_golite062009
  • purine-specific mismatch base pair DNA N-glycosylase activity
    		•  0.68578837518217 bayes_pls_golite062009
  • protein binding
    		•  0.663243680565331 bayes_pls_golite062009
  • mismatch base pair DNA N-glycosylase activity
    		•  0.661651574677137 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.57099109384393 bayes_pls_golite062009
  • RNA polymerase III transcription factor activity
    		•  0.365027701616215 bayes_pls_golite062009
  • carbon-oxygen lyase activity
    		•  0.0676784802238829 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.86

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle