YRC Public Data Repository - Protein Structure Prediction

Protein:	OGG1
Organism:	Saccharomyces cerevisiae
Length:	376 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for OGG1.

Description	E-value	Query Range	Subject Range
OGG1 - Mitochondrial glycosylase/lyase that specifically excises 7,8-dihydro-8-oxoguanine residues located ... gi\|190408183 - gi\|190408183\|gb\|EDV11448.1\| 43 kDa 8-oxo-guanine DNA glycosylase [Saccharomyces cerevisiae RM11-1a] OGG1_YEAST - N-glycosylase/DNA lyase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=OGG1 PE=1 SV=1	4.0E-85	[1..376]	[1..376]
OGG1 - 8-oxoguanine DNA glycosylase	1.0E-76	[5..344]	[23..338]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	9.0E-76	[5..344]	[23..339]
OGG1_RAT - N-glycosylase/DNA lyase OS=Rattus norvegicus GN=Ogg1 PE=2 SV=1	4.0E-74	[5..344]	[23..338]

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Predicted Domain #1

Region A:
Residues: [1-10]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSYKFGKLAI

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [30-82]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IWDEKLNQYS TTMKIGQQEK YSVVILRQDE ENEILEFVAV GDCGNQDALK THL

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [154-164]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LITTIDGVAY H

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	564.38764
Match:	1ko9A_
Description:	8-oxoguanine glycosylase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
DNA N-glycosylase activity	4.8124964619976	bayes_pls_golite062009
hydrolase activity, hydrolyzing N-glycosyl compounds	4.26870112679392	bayes_pls_golite062009
DNA-(apurinic or apyrimidinic site) lyase activity	3.71152530486175	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	3.62178291472984	bayes_pls_golite062009
transcription regulator activity	2.86205700023542	bayes_pls_golite062009
DNA binding	2.5120791469793	bayes_pls_golite062009
oxidized base lesion DNA N-glycosylase activity	2.49872706126491	bayes_pls_golite062009
nucleic acid binding	2.39934080314995	bayes_pls_golite062009
hydrolase activity	2.39042189031819	bayes_pls_golite062009
8-oxo-7,8-dihydroguanine DNA N-glycosylase activity	2.21048599823382	bayes_pls_golite062009
hydrolase activity, acting on glycosyl bonds	2.18053745735048	bayes_pls_golite062009
binding	2.13602784299456	bayes_pls_golite062009
catalytic activity	2.13345932727422	bayes_pls_golite062009
RNA polymerase II transcription factor activity	2.08009333103564	bayes_pls_golite062009
damaged DNA binding	2.00388798014411	bayes_pls_golite062009
alkylbase DNA N-glycosylase activity	1.5832578018127	bayes_pls_golite062009
oxidized purine base lesion DNA N-glycosylase activity	1.32985950765371	bayes_pls_golite062009
oxidized pyrimidine base lesion DNA N-glycosylase activity	1.2016453685638	bayes_pls_golite062009
DNA-3-methyladenine glycosylase I activity	1.06383943982125	bayes_pls_golite062009
transcription factor activity	0.91701565472544	bayes_pls_golite062009
transcription factor binding	0.88531282989512	bayes_pls_golite062009
uracil DNA N-glycosylase activity	0.879508131574476	bayes_pls_golite062009
structure-specific DNA binding	0.85419760398899	bayes_pls_golite062009
purine-specific mismatch base pair DNA N-glycosylase activity	0.68578837518217	bayes_pls_golite062009
protein binding	0.663243680565331	bayes_pls_golite062009
mismatch base pair DNA N-glycosylase activity	0.661651574677137	bayes_pls_golite062009
double-stranded DNA binding	0.57099109384393	bayes_pls_golite062009
RNA polymerase III transcription factor activity	0.365027701616215	bayes_pls_golite062009
carbon-oxygen lyase activity	0.0676784802238829	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [11-29]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NKSELCLANV LQAGQSFRW

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [83-118]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKYFRLDVSL KHLFDNVWIP SDKAFAKLSP QGIRIL

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [321-376]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GVLFSKEIGG TSGSTTTGTI KKRKWDMIKE TEAIVTKQMK LKVELSDLHI KEAKID

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	564.38764
Match:	1ko9A_
Description:	8-oxoguanine glycosylase
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [119-153]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AQEPWETLIS FICSSNNNIS RITRMCNSLC SNFGN

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [165-320]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SFPTSEELTS RATEAKLREL GFGYRAKYII ETARKLVNDK AEANITSDTT YLQSICKDAQ  60
   61 YEDVREHLMS YNGVGPKVAD CVCLMGLHMD GIVPVDVHVS RIAKRDYQIS ANKNHLKELR 120
  121 TKYNALPISR KKINLELDHI RLMLFKKWGS YAGWAQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	564.38764
Match:	1ko9A_
Description:	8-oxoguanine glycosylase
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: