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Protein Overview: CPR6

General Information:
Name(s) found: CPR6 / YLR216C [SGD]
Description(s) found:
Found 25 descriptions.
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  • Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 371 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed articleLink to PubMed articleLink to PubMed article]
    Biological Process: protein folding [IDALink to PubMed article][IPILink to PubMed article]
    Molecular Function: peptidyl-prolyl cis-trans isomerase activity [IDALink to PubMed articleLink to PubMed article]
    unfolded protein binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTRPKTFFDI SIGGKPQGRI VFELYNDIVP KTAENFLKLC EGNAGMAKTK PDVPLSYKGS  60
   61 IFHRVIKDFM CQFGDFTNFN GTGGESIYDE KFEDENFTVK HDKPFLLSMA NAGPNTNGSQ 120
  121 AFITCVPTPH LDGKHVVFGE VIQGKRIVRL IENQQCDQEN NKPLRDVKID DCGVLPDDYQ 180
  181 VPENAEATPT DEYGDNYEDV LKQDEKVDLK NFDTVLKAIE TVKNIGTEQF KKQNYSVALE 240
  241 KYVKCDKFLK EYFPEDLEKE QIEKINQLKV SIPLNIAICA LKLKDYKQVL VASSEVLYAE 300
  301 AADEKAKAKA LYRRGLAYYH VNDTDMALND LEMATTFQPN DAAILKAIHN TKLKRKQQNE 360
  361 KAKKSLSKMF S

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CPR6 HSC82 HSP82 QNS1 YHR033W
    View Details Krogan NJ, et al. (2006) AHA1 BUD3 CNS1 CPR6 DIG2 DNM1 DSF1, YNR073C FRT2 GPA2 HOM6 HSC82 HSP104 HSP82 MBB1 MRPL50 PAM1 PPT1 QNS1 RMD8 RTS1 SMT3 STI1 STP4 TDH1 UTP20 YBL104C
    View Details Ho Y, et al. (2002) AAC1 AAC3 ACC1 ADE5,7 ADH2 AHA1 ARC1 ARG4 ARO1 ARP2 ATG11 ATG12 ATG17 ATP3 AYR1 BCK1 BCY1 BUD32 CAF120 CAR2 CCT6 CDC33 COR1 CPA2 CPR6 CRM1 DIA4 EGD2 ERG27 ESS1 FAA4 FET4 FMP10 FOL2 GAL7 GCD11 GFA1 GND1 GPH1 GPT2 GRX3 GRX4 GUS1 HEF3 HSP104 HXT6 IDH1 IDH2 IDP2 ILV5 IMD2 IMD4 IPP1 JJJ1 KAE1 KIC1 KIN2 LHS1 LIA1 LYS12 MAE1 MDJ1 MDN1 MKK2 MKT1 MTC5 NAS6 NMD5 NPA3 NPR2 OLA1 OM45 OYE2 PCT1 PDA1 PDC6 PET10 PET9 PFK1 PHO81 PHO84 PIL1 PMA1 POX1 PPH21 PPH22 PPX1 PRB1 PRE10 PRO3 PTC7 PUP2 QCR2 QNS1 RCN2 REP1 RET2 REX2 RNH202 RNQ1 RNR2 RPB3 RPN1 RPN10 RPN11 RPN12 RPN14 RPN3 RPN5 RPN6 RPN7 RPN8 RPN9 RPO21 RPT1 RPT2 RPT3 RPT4 RPT5 RTN2 RVS161 SDH2 SEC18 SEC21 SEC23 SEC26 SEC27 SEC28 SEC53 SEH1 SGD1 SGO1 SIS1 SKG3 SLP1 SLT2 SMK1 SPS1 SPT5 STI1 TCB1 TFG1 THI21 TIF1, TIF2 TIF34 TIF35 TMA29 TOM1 TPA1 TPK1 TPK3 TRR1 TYR1 UBC12 URA7 UTP22 UTP5 VMA8 VPS74 YER138C YHR020W YHR033W YHR214W-A YNL181W YNL208W YPT7

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen PPG1 CPR6 2 Uetz P, et al. (2000)
    View Screen SGT1 CPR6 2 Unpublished Fields Lab Data
    View Screen PAC1 CPR6 2 Unpublished Fields Lab Data
    View Screen NSE4 CPR6 2 Unpublished Fields Lab Data
    View Screen SCH9 CPR6 2 Unpublished Fields Lab Data
    View Screen CPR6 NUP120 2 Unpublished Fields Lab Data
    View Screen CPR6 VMA10 2 Unpublished Fields Lab Data
    View Screen IMD1 CPR6 2 Unpublished Fields Lab Data
    View Screen SEC17 CPR6 1 Unpublished Fields Lab Data
    View Screen CPR6 MSH6 1 Unpublished Fields Lab Data
    View Screen CPR6 RHO3 1 Unpublished Fields Lab Data
    View Screen CPR6 MCM1 1 Unpublished Fields Lab Data
    View Screen KAP104 CPR6 1 Unpublished Fields Lab Data
    View Screen CPR6 MET32 1 Unpublished Fields Lab Data
    View Screen CPR6 CCT7 1 Unpublished Fields Lab Data
    View Screen CPR6 MED11 1 Unpublished Fields Lab Data
    View Screen KAP104 CPR6 1 Unpublished Fields Lab Data
    View Screen CPR6 HIM1 1 Unpublished Fields Lab Data
    View Screen CPR6 BFA1 1 Unpublished Fields Lab Data
    View Screen CPR6 HLJ1 1 Unpublished Fields Lab Data
    View Screen CPR6 RNR1 1 Unpublished Fields Lab Data
    View Screen CPR6 IME1 1 Unpublished Fields Lab Data
    View Screen CPR6 UBP8 1 Unpublished Fields Lab Data
    View Screen RAD53 CPR6 1 Unpublished Fields Lab Data
    View Screen CDC23 CPR6 1 Unpublished Fields Lab Data
    View Screen CPR6 ALD5 1 Unpublished Fields Lab Data
    View Screen CPR6 ABM1 1 Unpublished Fields Lab Data
    View Screen CPR6 NSG2 1 Unpublished Fields Lab Data
    View Screen CPR6 RSP5 1 Unpublished Fields Lab Data
    View Screen CPR6 SLA2 1 Unpublished Fields Lab Data
    View Screen GYP6 CPR6 1 Unpublished Fields Lab Data
    View Screen CPR6 SPT15 1 Unpublished Fields Lab Data
    View Screen CPR6 YKL061W 1 Unpublished Fields Lab Data
    View Screen CPR6 MED4 1 Unpublished Fields Lab Data
    View Screen CPR6 PRP45 1 Unpublished Fields Lab Data
    View Screen CPR6 YFR045W 1 Unpublished Fields Lab Data
    View Screen CPR6 YKR051W 1 Unpublished Fields Lab Data
    View Screen CPR6 ISU2 1 Unpublished Fields Lab Data
    View Screen CPR6 PTA1 1 Unpublished Fields Lab Data
    View Screen CPR6 JAC1 1 Unpublished Fields Lab Data
    View Screen CPR6 YKR104W 1 Unpublished Fields Lab Data
    View Screen CPR6 CHL1 1 Unpublished Fields Lab Data
    View Screen CPR6 YBL077W 1 Unpublished Fields Lab Data
    View Screen CPR6 SPT4 1 Unpublished Fields Lab Data
    View Screen CPR6 MCM5 1 Unpublished Fields Lab Data
    View Screen CPR6 SMA1 1 Unpublished Fields Lab Data
    View Screen CPR6 GIP1 1 Unpublished Fields Lab Data
    View Screen CPR6 HIP1 1 Unpublished Fields Lab Data
    View Screen CPR6 YLR345W 1 Unpublished Fields Lab Data
    View Screen CPR6 VPS30 1 Unpublished Fields Lab Data
    View Screen CPR6 SYP1 1 Unpublished Fields Lab Data
    View Screen CPR6 YHL050C 1 Unpublished Fields Lab Data
    View Screen CPR6 BUD8 1 Unpublished Fields Lab Data
    View Screen CPR6 NOP53 1 Unpublished Fields Lab Data
    View Screen CPR6 AHC2 1 Unpublished Fields Lab Data
    View Screen CPR6 YLR402W 1 Unpublished Fields Lab Data
    View Screen CPR6 NSL1 1 Unpublished Fields Lab Data
    View Screen CPR6 ENT1 1 Unpublished Fields Lab Data
    View Screen CPR6 PEX18 1 Unpublished Fields Lab Data
    View Screen CPR6 YML045W 1 Unpublished Fields Lab Data
    View Screen CPR6 YPR172W 1 Unpublished Fields Lab Data
    View Screen CPR6 NRG1 1 Unpublished Fields Lab Data
    View Screen CPR6 THP2 1 Unpublished Fields Lab Data
    View Screen CPR6 ARG81 1 Unpublished Fields Lab Data
    View Screen CPR6 RPO26 1 Unpublished Fields Lab Data
    View Screen CPR6 PAA1 1 Unpublished Fields Lab Data
    View Screen CPR6 RSM25 1 Unpublished Fields Lab Data
    View Screen CPR6 CDC5 1 Unpublished Fields Lab Data
    View Screen PLB1 CPR6 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data CPR6 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..188] PSI-BLAST 919.218487 Cyclophilin 40; Cyclophilin 40 isomerase domain
    2 View Details [189..283] PSI-BLAST 919.218487 Cyclophilin 40; Cyclophilin 40 isomerase domain
    3 View Details [284..371] PSI-BLAST 919.218487 Cyclophilin 40; Cyclophilin 40 isomerase domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein deacetylase activity
    		•  4.3775483906311 bayes_pls_golite062009
  • histone deacetylase activity
    		•  4.29026678196473 bayes_pls_golite062009
  • peptidyl-prolyl cis-trans isomerase activity
    		•  3.73853378771688 bayes_pls_golite062009
  • cis-trans isomerase activity
    		•  3.66963215732405 bayes_pls_golite062009
  • deacetylase activity
    		•  3.49940864924766 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
    		•  3.01511519120932 bayes_pls_golite062009
  • RNA binding
    		•  2.94609837984526 bayes_pls_golite062009
  • signal sequence binding
    		•  2.68460419248567 bayes_pls_golite062009
  • isomerase activity
    		•  1.96529188741504 bayes_pls_golite062009
  • binding
    		•  1.65866393331484 bayes_pls_golite062009
  • mRNA binding
    		•  1.45537055700871 bayes_pls_golite062009
  • unfolded protein binding
    		•  1.38124355054041 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.26149030245805 bayes_pls_golite062009
  • peroxisome targeting sequence binding
    		•  1.01220052237687 bayes_pls_golite062009
  • DNA binding
    		•  0.9531600253493 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.939772862764466 bayes_pls_golite062009
  • catalytic activity
    		•  0.748655649755714 bayes_pls_golite062009
  • hydrolase activity
    		•  0.493806105600863 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    		•  0.408539130322443 bayes_pls_golite062009
  • transcription factor activity
    		•  0.374364600772076 bayes_pls_golite062009
  • drug binding
    		•  0.36339132904137 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  0.322244688184474 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  0.286133802341887 bayes_pls_golite062009
  • histone binding
    		•  0.268719695649015 bayes_pls_golite062009
  • protein binding
    		•  0.230077752280113 bayes_pls_golite062009
  • N-acetyltransferase activity
    		•  0.105969834846946 bayes_pls_golite062009
  • receptor binding
    		•  0.0640017685740477 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle