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Protein Overview: YLR345W

General Information:
Name(s) found: YLR345W [SGD]
Description(s) found:
Found 22 descriptions.
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  • Similar to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase enzymes responsible for the metabolism of fructoso-2,6-bisphosphate; mRNA expression is repressed by the Rfx1p-Tup1p-Ssn6p repressor complex; YLR345W is not an essential gene [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 509 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: fructose 2,6-bisphosphate metabolic process [NASLink to PubMed article]
    regulation of glycolysis [NASLink to PubMed article]
    Molecular Function: 6-phosphofructo-2-kinase activity [NASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPNVLSDDEE LLNGLGSEIM KPSRQGNHMA RTVKRWVNKE RATTADLKNV NIDGVHGPVN  60
   61 TESYISPGQL YSTDSGNLFH AGRILVVLVG LPATSKTLLS VAITRYTRWL GVRTKSFHFS 120
  121 EYKESAKNIP SDYFCVVPTS KEGVAFVEKL RMQMLNDILA FFNDLSGQLA IYDALNIRKI 180
  181 DRKNLETTFS EIGVKVLFIE SIVSDQEIMN RNIALALESN DYKGLSTDEA IDEYMRRLSV 240
  241 NEPYYEMMTH DEELSYIKYI NLGKQIIVKD NIHGYLVNKI VFFLMNLRQK KGCVYFARCG 300
  301 TSDKDNYIHD EELNEEGIHY SQVLKDFVLQ RIKQKRQAKK NSDSLVEVID GSHDEDLKTS 360
  361 LIVWTGPRKR THDTALFFSK EGIKVQQRSE LRQLNPGSIA DLTDQQIMDK FPSEYKESLK 420
  421 DPYHFRFPRA ESYHDLAVRM EPLLLEMEHT SKDILIIAHE STLRVLYGYL MACTCVELPN 480
  481 LNFTRDKLVE ISFSPFCNTV ELLNIPLTS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) FBP26 YLR345W
    View Details Krogan NJ, et al. (2006) FBP26 STE13 YLR345W
    View Details Gavin AC, et al. (2006) FBP26 YLR345W

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data YLR345W Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..289] PSI-BLAST 638.228787 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain; 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain
    2 View Details [290..509] PSI-BLAST 638.228787 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain; 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.92

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle