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Protein Overview: STE13

General Information:
Name(s) found: STE13 / YOR219C [SGD]
Description(s) found:
Found 30 descriptions.
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  • Dipeptidyl aminopeptidase, Golgi integral membrane protein that cleaves on the carboxyl side of repeating -X-Ala- sequences, required for maturation of alpha factor, transcription is induced by a-factor [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 931 amino acids

    Gene Ontology:
    Cellular Component: trans-Golgi network [IDALink to PubMed article]
    Biological Process: peptide pheromone maturation [IDALink to PubMed article][IMPLink to PubMed article]
    Molecular Function: aminopeptidase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSASTHSHKR KNSHLFPQRK SSNSSMDKPF FPNNDSVANT DPQSNENGHT INEIRPTEAT  60
   61 IDVTDVPQTP FLQEQYSMRP RRESFQFNDI ENQHHTHSFF SVNKFNRRWG EWSLPEKRSY 120
  121 VLVFTLIALS VLVLLVILIP SKLLPTKITR PKTSAGDSSL GKRSFSIENV LNGDFAIPED 180
  181 TFHFIDPPQR LLGQDSDPGL YFTTKEIDGH TNFIAKQLFD ETFEVNLGGN RFLYEGVEFT 240
  241 VSTVQINYKL DKLIFGTNLE SEFRHSSKGF YWIKDLNTGN IEPILPPEKS DDNYELGLSK 300
  301 LSYAHFSPAY NYIYFVYENN LFLQQVNSGV AKKVTEDGSK DIFNAKPDWI YEEEVLASDQ 360
  361 AIWWAPDDSK AVFARFNDTS VDDIRLNRYT NMNEAYLSDT KIKYPKPGFQ NPQFDLFLVN 420
  421 LQNGIIYSIN TGGQKDSILY NGKWISPDTF RFEITDRNSK ILDVKVYDIP SSQMLTVRNT 480
  481 NSNLFNGWIE KTKDILSIPP KPELKRMDYG YIDIHADSRG FSHLFYYPTV FAKEPIQLTK 540
  541 GNWEVTGNGI VGYEYETDTI FFTANEIGVM SQHLYSISLT DSTTQNTFQS LQNPSDKYDF 600
  601 YDFELSSSAR YAISKKLGPD TPIKVAGPLT RVLNVAEIHD DSILQLTKDE KFKEKIKNYD 660
  661 LPITSYKTMV LDDGVEINYI EIKPANLNPK KKYPILVNIY GGPGSQTFTT KSSLAFEQAV 720
  721 VSGLDVIVLQ IEPRGTGGKG WSFRSWAREK LGYWEPRDIT EVTKKFIQRN SQHIDESKIA 780
  781 IWGWSYGGFT SLKTVELDNG DTFKYAMAVA PVTNWTLYDS VYTERYMNQP SENHEGYFEV 840
  841 STIQNFKSFE SLKRLFIVHG TFDDNVHIQN TFRLVDQLNL LGLTNYDMHI FPDSDHSIRY 900
  901 HNAQRIVFQK LYYWLRDAFA ERFDNTEVLH L

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) FBP26 STE13 YLR345W
    View Details Qiu et al. (2008) KEX1 KEX2 STE13

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)
    View Run None Entered #17 Mitotic Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..114] MSA 1.019936 View MSA. No confident structure predictions are available.
    2 View Details [115..215] MSA 1.053994 View MSA. No confident structure predictions are available.
    3 View Details [216..307] PSI-BLAST 6.30103 TolB, C-terminal domain; TolB, N-terminal domain
    4 View Details [308..345]
    [453..456]
    [654..931]    		 PSI-BLAST 85.39794 Prolyl oligopeptidase, N-terminal domain; Prolyl oligopeptidase, C-terminal domain
    5 View Details [346..452]
    [457..653]    		 PSI-BLAST 85.39794 Prolyl oligopeptidase, N-terminal domain; Prolyl oligopeptidase, C-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • hydrolase activity
    		•  4.09944423676394 bayes_pls_golite062009
  • peptidase activity
    		•  2.49064988313037 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  2.10044305272656 bayes_pls_golite062009
  • catalytic activity
    		•  1.39629727416851 bayes_pls_golite062009
  • palmitoyl-(protein) hydrolase activity
    		•  1.01438408843885 bayes_pls_golite062009
  • binding
    		•  0.549512873906854 bayes_pls_golite062009
  • heparin binding
    		•  0.437236652275566 bayes_pls_golite062009
  • endopeptidase activity
    		•  0.43631945855397 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  0.282381128231187 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
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