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Protein Overview: KEX1

General Information:
Name(s) found: KEX1 / YGL203C [SGD]
Description(s) found:
Found 25 descriptions.
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  • Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 729 amino acids

    Gene Ontology:
    Cellular Component: trans-Golgi network [IDALink to PubMed article]
    Biological Process: protein processing [TASLink to PubMed article]
    Molecular Function: carboxypeptidase D activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFYNRWLGTW LAMSALIRIS VSLPSSEEYK VAYELLPGLS EVPDPSNIPQ MHAGHIPLRS  60
   61 EDADEQDSSD LEYFFWKFTN NDSNGNVDRP LIIWLNGGPG CSSMDGALVE SGPFRVNSDG 120
  121 KLYLNEGSWI SKGDLLFIDQ PTGTGFSVEQ NKDEGKIDKN KFDEDLEDVT KHFMDFLENY 180
  181 FKIFPEDLTR KIILSGESYA GQYIPFFANA ILNHNKFSKI DGDTYDLKAL LIGNGWIDPN 240
  241 TQSLSYLPFA MEKKLIDESN PNFKHLTNAH ENCQNLINSA STDEAAHFSY QECENILNLL 300
  301 LSYTRESSQK GTADCLNMYN FNLKDSYPSC GMNWPKDISF VSKFFSTPGV IDSLHLDSDK 360
  361 IDHWKECTNS VGTKLSNPIS KPSIHLLPGL LESGIEIVLF NGDKDLICNN KGVLDTIDNL 420
  421 KWGGIKGFSD DAVSFDWIHK SKSTDDSEEF SGYVKYDRNL TFVSVYNASH MVPFDKSLVS 480
  481 RGIVDIYSND VMIIDNNGKN VMITTDDDSD QDATTESGDK PKENLEEEEQ EAQNEEGKEK 540
  541 EGNKDKDGDD DNDNDDDDED DHNSEGDDDD DDDDDEDDNN EKQSNQGLED SRHKSSEYEQ 600
  601 EEEEVEEFAE EISMYKHKAV VVTIVTFLIV VLGVYAYDRR VRRKARHTIL VDPNNRQHDS 660
  661 PNKTVSWADD LESGLGAEDD LEQDEQLEGG APISSTSNKA GSKLKTKKKK KYTSLPNTEI 720
  721 DESFEMTDF

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) GLO3 ISA2 KEX1 LYS20 RPL37B YBL086C
    View Details Qiu et al. (2008) KEX1 KEX2 STE13

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data KEX1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..231]
    [335..389]    		 PSI-BLAST 10126.0 Serine carboxypeptidase II
    2 View Details [232..240]
    [390..505]    		 PSI-BLAST 10126.0 Serine carboxypeptidase II
    3 View Details [241..334] PSI-BLAST 10126.0 Serine carboxypeptidase II
    4 View Details [506..590] ORFEUS 7.88 No description for 1l8mA was found.
    5 View Details [591..660] ORFEUS 7.88 No description for 1l8mA was found.
    6 View Details [661..729] ORFEUS 7.88 No description for 1l8mA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • hydrolase activity
    		•  4.09944423676394 bayes_pls_golite062009
  • peptidase activity
    		•  2.49064988313037 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  2.10044305272656 bayes_pls_golite062009
  • catalytic activity
    		•  1.39629727416851 bayes_pls_golite062009
  • palmitoyl-(protein) hydrolase activity
    		•  1.3250951453762 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  0.541803897301601 bayes_pls_golite062009
  • endopeptidase activity
    		•  0.43631945855397 bayes_pls_golite062009
  • binding
    		•  0.351031277062254 bayes_pls_golite062009
  • palmitoyl-CoA hydrolase activity
    		•  0.1174692258176 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle