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Protein Overview: ISU2

General Information:
Name(s) found: ISU2 / YOR226C [SGD]
Description(s) found:
Found 30 descriptions.
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  • Conserved protein of the mitochondrial matrix, required for synthesis of mitochondrial and cytosolic iron-sulfur proteins, performs a scaffolding function in mitochondria during Fe/S cluster assembly; isu1 isu2 double mutant is inviable [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 156 amino acids

    Gene Ontology:
    Cellular Component: mitochondrial matrix [IDALink to PubMed articleLink to PubMed article]
    Biological Process: cellular iron ion homeostasis [IMPLink to PubMed article][ISSLink to PubMed article]
    iron-sulfur cluster assembly [IMPLink to PubMed articleLink to PubMed article][ISSLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFARLANPAH FKPLTGSHIT RAAKRLYHPK VIDHYTNPRN VGSMDKSLAN VGTGIVGAPA  60
   61 CGDVIKLQIQ VNDKSGIIEN VKFKTFGCGS AIASSSYMTE LVRGMSLDEA VKIKNTEIAK 120
  121 ELSLPPVKLH CSMLAEDAIK AAIKDYKTKR NPSVLH

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen ERT1 ISU2 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data ISU2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..156] Pfam 78.013228 NifU-like N terminal domain No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  1.25897597318598 bayes_pls_golite062009
  • iron ion binding
    		•  0.905595388647019 bayes_pls_golite062009
  • protein binding
    		•  0.257846679116775 bayes_pls_golite062009
  • catalytic activity
    		•  0.256292883613773 bayes_pls_golite062009
  • transition metal ion binding
    		•  0.192770514366253 bayes_pls_golite062009
  • 2 iron, 2 sulfur cluster binding
    		•  0.0439466134407704 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle