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Protein Overview: CCT7

General Information:
Name(s) found: CCT7 / YJL111W [SGD]
Description(s) found:
Found 25 descriptions.
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  • Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 550 amino acids

    Gene Ontology:
    Cellular Component: chaperonin-containing T-complex [IPILink to PubMed article][TASLink to PubMed article]
    cytoskeleton [TASLink to PubMed article]
    cytoplasm [IDALink to PubMed article][TASLink to PubMed article]
    Biological Process: cytoskeleton organization [TASLink to PubMed article]
    protein folding [TASLink to PubMed article]
    Molecular Function: unfolded protein binding [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNFGSQTPTI VVLKEGTDAS QGKGQIISNI NACVAVQEAL KPTLGPLGSD ILIVTSNQKT  60
   61 TISNDGATIL KLLDVVHPAA KTLVDISRAQ DAEVGDGTTS VTILAGELMK EAKPFLEEGI 120
  121 SSHLIMKGYR KAVSLAVEKI NELAVDITSE KSSGRELLER CARTAMSSKL IHNNADFFVK 180
  181 MCVDAVLSLD RNDLDDKLIG IKKIPGGAME ESLFINGVAF KKTFSYAGFE QQPKKFNNPK 240
  241 ILSLNVELEL KAEKDNAEVR VEHVEDYQAI VDAEWQLIFE KLRQVEETGA NIVLSKLPIG 300
  301 DLATQFFADR NIFCAGRVSA DDMNRVIQAV GGSIQSTTSD IKPEHLGTCA LFEEMQIGSE 360
  361 RYNLFQGCPQ AKTCTLLLRG GAEQVIAEVE RSLHDAIMIV KRALQNKLIV AGGGATEMEV 420
  421 SKCLRDYSKT IAGKQQMIIN AFAKALEVIP RQLCENAGFD AIEILNKLRL AHSKGEKWYG 480
  481 VVFETENIGD NFAKFVWEPA LVKINALNSA TEATNLILSV DETITNKGSE SANAGMMPPQ 540
  541 GAGRGRGMPM

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) CCT2 CCT3 CCT4 CCT5 CCT6 CCT7 CCT8 TCP1
    View Details Gavin AC, et al. (2006) CCT2 CCT7 PLP2 VID27
    View Details Gavin AC, et al. (2002) CCT6 CCT7 TAP42
    View Details Qiu et al. (2008) CCT2 CCT3 CCT4 CCT5 CCT6 CCT7 CCT8 SSA2 TCP1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run LST8 No Comments Reinke A, et al. (2004)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi 1 with ha tag from october 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi1 with gst from october 2005 McCusker D, et al (2007)
    View Run VAM3 Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control). Hao Xu, et al. (2010)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..110]
    [144..411]
    [494..550]    		 PSI-BLAST 1057.0 Thermosome, E domain; Thermosome, A-domain; Thermosome, I domain
    2 View Details [111..143]
    [412..493]    		 PSI-BLAST 1057.0 Thermosome, E domain; Thermosome, A-domain; Thermosome, I domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • unfolded protein binding
    		•  7.60116801069598 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  3.6934849790316 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  3.40373598585301 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  3.28982639907979 bayes_pls_golite062009
  • binding
    		•  2.07154556649829 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.67284737458957 bayes_pls_golite062009
  • DNA binding
    		•  1.60256620441721 bayes_pls_golite062009
  • transporter activity
    		•  1.27879339110564 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.08697283907212 bayes_pls_golite062009
  • chaperone binding
    		•  0.91200031047441 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.828920415160435 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  0.787685249362834 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.75018875403424 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.69634667457441 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.682843768728088 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.680378643689288 bayes_pls_golite062009
  • protein binding
    		•  0.634982583867058 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.630986103152935 bayes_pls_golite062009
  • ATPase activity
    		•  0.584574936611857 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.573106450426516 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  0.44379130337188 bayes_pls_golite062009
  • catalytic activity
    		•  0.424959044318554 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.280310103153739 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.275534581026027 bayes_pls_golite062009
  • hydrogen-exporting ATPase activity, phosphorylative mechanism
    		•  0.26275673855778 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.252704226951294 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  0.243984617084631 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  0.205808843369749 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  0.202279803135899 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  0.20198255686005 bayes_pls_golite062009
  • transferase activity
    		•  0.18639662517366 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.16424934648837 bayes_pls_golite062009
  • kinase activity
    		•  0.0871496920547826 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.0778814959589007 bayes_pls_golite062009
  • hydrolase activity
    		•  0.0491351110520448 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle