YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: PLP2

General Information:
Name(s) found: PLP2 / YOR281C [SGD]
Description(s) found:
Found 40 descriptions.
SHOW ALL
  • Essential protein that interacts with the CCT (chaperonin containing TCP-1) complex to stimulate actin folding; has similarity to phosducins; null mutant lethality is complemented by mouse phosducin-like protein MgcPhLP [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 286 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IPILink to PubMed article]
    Biological Process: positive regulation of transcription from RNA polymerase II promoter by pheromones [IMPLink to PubMed article][IPILink to PubMed article]
    Molecular Function: GTPase inhibitor activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQNEPMFQVQ VDESEDSEWN DILRAKGVIP ERAPSPTAKL EEALEEAIAK QHENRLEDKD  60
   61 LSDLEELEDD EDEDFLEAYK IKRLNEIRKL QERSKFGEVF HINKPEYNKE VTLASQGKKY 120
  121 EGAQTNDNGE EDDGGVYVFV HLSLQSKLQS RILSHLFQSA ACKFREIKFV EIPANRAIEN 180
  181 YPESNCPTLI VYYRGEVIKN MITLLELGGN NSKMEDFEDF MVKVGAVAEG DNRLIMNRDD 240
  241 EESREERKLH YGEKKSIRSG IRGKFNVGIG GNDDGNINDD DDGFFD

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Gavin AC, et al. (2006) CCT2 CCT7 PLP2 VID27

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PLP2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..237] PSI-BLAST 59.27013 Phosducin
    2 View Details [238..286] PSI-BLAST 5.045757 Protein disulfide isomerase, PDI

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein disulfide isomerase activity
    		•  2.22938352402713 bayes_pls_golite062009
  • intramolecular oxidoreductase activity, transposing S-S bonds
    		•  2.22938352402713 bayes_pls_golite062009
  • intramolecular oxidoreductase activity, interconverting keto- and enol-groups
    		•  2.0668189994058 bayes_pls_golite062009
  • antioxidant activity
    		•  1.38472228155226 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.26775679034218 bayes_pls_golite062009
  • protein binding
    		•  1.18479617596618 bayes_pls_golite062009
  • peroxidase activity
    		•  1.15636364216535 bayes_pls_golite062009
  • oxidoreductase activity, acting on peroxide as acceptor
    		•  1.15636364216535 bayes_pls_golite062009
  • disulfide oxidoreductase activity
    		•  0.893289664404565 bayes_pls_golite062009
  • catalytic activity
    		•  0.672192331361968 bayes_pls_golite062009
  • binding
    		•  0.618139748326926 bayes_pls_golite062009
  • peroxiredoxin activity
    		•  0.366096607480921 bayes_pls_golite062009
  • glutathione peroxidase activity
    		•  0.360252986649711 bayes_pls_golite062009
  • transcription activator activity
    		•  0.322947914353705 bayes_pls_golite062009
  • protein disulfide oxidoreductase activity
    		•  0.27885589181966 bayes_pls_golite062009
  • thioredoxin peroxidase activity
    		•  0.163136748643487 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle