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Protein Overview: NSG2

General Information:
Name(s) found: NSG2 / YNL156C [SGD]
Description(s) found:
Found 29 descriptions.
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  • Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; homolog of mammalian INSIG proteins [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 299 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum [IDALink to PubMed article]
    Biological Process: sterol biosynthetic process [IGILink to PubMed article]
    Molecular Function: protein binding [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MANRGEPDPK KSTESICSLT KPQLYSLYDD DVVRSEDNEI YEELKRSVSI DSTKYSRDQT  60
   61 IDSTFYLAHK VGGSLPRNTV SSNNLERILS ASSIHENFPS RTRQTRQNIL HYLQAVLILS 120
  121 LSGFAYHELS RNLHDNHLLH PDFASRPLLL GVKLCNWLSN GVLPNWLGYG VEGLLFGSVV 180
  181 PILDNIFQTE VVKSSVHHDS LTSVIRSINA MLGVTFGIRK IQWNSSLQAA GAWGLLNIIL 240
  241 WLFFDGSISM LMSCICIGVG CCISCYKDII DGSQFLYFMD FYFLGSLMFG KLGRYLYSH

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data NSG2 Huh WK, et al. (2003)

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..63] deduced N/A No confident structure predictions are available.
    2 View Details [64..299] ORFEUS 7.18 Trichodiene synthase


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle